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• W4290102427 startingPage "83" @default.
• W4290102427 abstract "A major challenge to antimalarial chemotherapy is the spreading resistance to antimalarial drugs. The use of effective and safe antimalarial drugs has been the backbone of malaria elimination programs. Though many efforts and resources have been committed to developing of new and effective antimalarial drugs, however, the rapid spread of resistance has limped all the efforts. Emerging of drug resistance has been a significant issue in the last decade. Artemisinin-based combination therapy (ACT) has been the first-line treatment of Plasmodium falciparum after the emerging of chloroquine and sulfadoxine–pyrimethamine resistance. The ACTs combine the long-acting drugs with fast-acting artemisinin derivatives to ensure complete remission from the disease. At the beginning, antimalarial drugs are effective in clearing the malarial parasite, but successive clearance leads to selection pressure making the parasite fit to survive and proliferate under the effect of an antimalarial drugs. Furthermore, non-specific drug targeting of conventional antimalarial drugs results in the need for administration of higher dose and subsequent intolerable side effects leading to patient noncompliance and toxicity. For these reasons, new and out of the box strategies and techniques to deliver the antimalarial drug specifically to the site of action are required. Research is ongoing in the field of nanomedicine, to develop nanocarrier systems capable of incorporating drugs, lowering the resistance process with control and treatment of malaria by targeted delivery. Targeting drugs, especially to their site of action would indeed enable the optimal concentration of the drug in malarial parasite-infected red blood cells (pRBCs) and infected liver tissues. Polymers, lipids, proteins, liposomes, and other materials have been explored as nanocarriers for targeted drug delivery to infected cells because of their preferential binding to pRBCs, low toxicity and high biodegradability. This chapter discusses the various approaches in antimalarial chemotherapy using nanotechnology-based drug delivery systems that might be beneficial to reduce the emergence of drug resistance." @default.
• W4290102427 created "2022-08-06" @default.
• W4290102427 creator A5007118748 @default.
• W4290102427 creator A5034902895 @default.
• W4290102427 creator A5035259718 @default.
• W4290102427 date "2022-08-05" @default.
• W4290102427 modified "2023-10-15" @default.
• W4290102427 title "Targeted Drug Delivery for Antimalarial Therapy" @default.
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