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- W4290198908 abstract "The eukaryotic cell cycle is characterized by two major events, DNA replication (S phase) and mitosis (M phase). According to the current paradigm of the cell cycle as a cdc2 cycle, both of these events are driven by serine-threonine specific protein kinases encoded by functional homologs of the fission yeast cdc2 gene. To understand how cdc2 kinases function, it is necessary to identify their physiological substrates and to determine how phosphorylation of these substrates promotes cell cycle progression. Definitive information about substrates relevant to early stages of the cell cycle (G1 and S phases) remains scarce, but several likely physiological targets of the mitotic cdc2 kinase have recently been identified. Current evidence indicates that cdc2 kinase may trigger entry of cells into mitosis not only by initiating important regulatory pathways but also by direct phosphorylation of abundant structural proteins." @default.
- W4290198908 created "2022-08-07" @default.
- W4290198908 creator A5067286626 @default.
- W4290198908 date "1991-08-01" @default.
- W4290198908 modified "2023-09-29" @default.
- W4290198908 title "The substrates of the cdc2 kinase." @default.
- W4290198908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1842344" @default.
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