Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290216096> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4290216096 endingPage "3" @default.
- W4290216096 startingPage "557" @default.
- W4290216096 abstract "When a lizard loses its tail, a new caudal appendage soon grows to replace the one that is missing. But when a human loses a kidney, severs a peripheral nerve or worse, the spinal cord, that organ is lost forever. Such at least is conventional thinking. But imagine that the victim of an industrial accident with a paralyzed hand could achieve new levels of function by inducing axonal regrowth through a synthetic nerve guidance channel; or that a Parkinsonian patient's symptoms could be relieved by implanting in his brain neural tissue encased in a selectively permeable polymer envelope; or that the inexorable progression of the vascular complications of juvenile diabetes could be stopped, even reversed, by a membrane-protected xenograft of insulin-producing tissue. This is the dream of bionic organ science. It is predicated on two lines of technological achievement: the availability of ultra-thin, biocompatible, selectively permeable polymer membranes which can protect a transplant against immune rejection while allowing solute exchange between the graft and its environment; and the synthesis of novel materials, some biostable, some bioresorbable, which can serve as scaffolding or anchor for tissue regrowth in the geometrically and chemically controlled environment of an implant. The fabrication, growth and survival of composites of living tissues with synthetic polymers, often enhanced by the incorporation of specific cell growth factors or inhibitors, has been demonstrated at the tissue culture level, and extended in vivo to experimental models of human endocrine deficiency or neurological defects. The key to progress with bioartificial organs is the confluence of knowledge ranging from materials science to cell and molecular biology to experimental surgery. Obstacles to clinical implementation of this new therapeutic concept include: large scale procurement of specific tissue structures or isolated postmitotic cells from animal sources; demonstration of safety and efficacy of spontaneously occurring, bioactive tumor cell lines; verification of long-term stability and bio-acceptance of polymer implants; and industrialization of the fabrication process to meet quality control, shelf-life and commercial distribution requirements.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
- W4290216096 created "2022-08-07" @default.
- W4290216096 creator A5068815987 @default.
- W4290216096 date "1991-01-01" @default.
- W4290216096 modified "2023-09-29" @default.
- W4290216096 title "Bionic organs." @default.
- W4290216096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1816705" @default.
- W4290216096 hasPublicationYear "1991" @default.
- W4290216096 type Work @default.
- W4290216096 citedByCount "0" @default.
- W4290216096 crossrefType "journal-article" @default.
- W4290216096 hasAuthorship W4290216096A5068815987 @default.
- W4290216096 hasConcept C105702510 @default.
- W4290216096 hasConcept C1318750 @default.
- W4290216096 hasConcept C136229726 @default.
- W4290216096 hasConcept C141071460 @default.
- W4290216096 hasConcept C150903083 @default.
- W4290216096 hasConcept C207001950 @default.
- W4290216096 hasConcept C2781411149 @default.
- W4290216096 hasConcept C2911091166 @default.
- W4290216096 hasConcept C49892992 @default.
- W4290216096 hasConcept C71924100 @default.
- W4290216096 hasConcept C86803240 @default.
- W4290216096 hasConcept C89429830 @default.
- W4290216096 hasConceptScore W4290216096C105702510 @default.
- W4290216096 hasConceptScore W4290216096C1318750 @default.
- W4290216096 hasConceptScore W4290216096C136229726 @default.
- W4290216096 hasConceptScore W4290216096C141071460 @default.
- W4290216096 hasConceptScore W4290216096C150903083 @default.
- W4290216096 hasConceptScore W4290216096C207001950 @default.
- W4290216096 hasConceptScore W4290216096C2781411149 @default.
- W4290216096 hasConceptScore W4290216096C2911091166 @default.
- W4290216096 hasConceptScore W4290216096C49892992 @default.
- W4290216096 hasConceptScore W4290216096C71924100 @default.
- W4290216096 hasConceptScore W4290216096C86803240 @default.
- W4290216096 hasConceptScore W4290216096C89429830 @default.
- W4290216096 hasIssue "6" @default.
- W4290216096 hasLocation W42902160961 @default.
- W4290216096 hasOpenAccess W4290216096 @default.
- W4290216096 hasPrimaryLocation W42902160961 @default.
- W4290216096 hasRelatedWork W1983428815 @default.
- W4290216096 hasRelatedWork W2051804893 @default.
- W4290216096 hasRelatedWork W2080151262 @default.
- W4290216096 hasRelatedWork W2124195334 @default.
- W4290216096 hasRelatedWork W2317171318 @default.
- W4290216096 hasRelatedWork W2534008105 @default.
- W4290216096 hasRelatedWork W2602055249 @default.
- W4290216096 hasRelatedWork W2947005505 @default.
- W4290216096 hasRelatedWork W4214503728 @default.
- W4290216096 hasRelatedWork W4247067294 @default.
- W4290216096 hasVolume "53" @default.
- W4290216096 isParatext "false" @default.
- W4290216096 isRetracted "false" @default.
- W4290216096 workType "article" @default.