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- W4290245218 abstract "N-Nitroso-N-methylaniline (NMA) is a strong oesophageal carcinogen in rats but exhibits few overt genotoxic effects. Previous work from our laboratory established that NMA is readily metabolized by cytochrome P450-catalysed N-demethylation to produce the benzenediazonium ion (BDI), a relatively stable but reactive electrophilic agent. We have also shown that BDI reacts with DNA to form an acid-labile adduct. We have now shown that BDI, generated chemically or by the metabolism of NMA in vitro, reacts with DNA to form a triazene coupling product at the N6-position of adenine residues. This adduct has also been shown to be produced in the liver DNA of rats treated with NMA. Procedures for the isolation of DNA and for analysis of the adduct are presented." @default.
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- W4290245218 date "1991-01-01" @default.
- W4290245218 modified "2023-09-27" @default.
- W4290245218 title "Mechanism of DNA binding by the oesophageal carcinogen N-nitroso-N-methylaniline." @default.
- W4290245218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1855878" @default.
- W4290245218 hasPublicationYear "1991" @default.
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