Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290249136> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4290249136 endingPage "61" @default.
- W4290249136 startingPage "55" @default.
- W4290249136 abstract "Recombinant granulocyte colony-stimulating factor (rG-CSF) primed the ability of human neutrophils to generate increased levels of reactive oxidants in response to fMet-Leu-Phe, and also resulted in an increased rate of protein biosynthesis which was similar to that induced by granulocyte-macrophage colony-stimulating factor. However, rG-CSF reduced the chemotactic activity of neutrophils in response to endotoxin and did not result in an enhanced rate of killing of Staphylococcus aureus. rG-CSF was administered to patients after high dose chemotherapy and autologous bone marrow transplantation for the treatment of either Hodgkin's disease or multiple myeloma. This cytokine decreased the period of neutropenia following such treatment. Neutrophil function in two patients, measured seven days after the final administration of rG-CSF, was severely impaired as indicated by a greatly decreased ability to generate reactive oxidants. However, seven days later (i.e. 14 days post-therapy), the functional activity of the neutrophils from these patients had returned to normal. These data indicate that assays of neutrophil function together with morphological assessment of neutrophil numbers and maturity should be performed in order to evaluate the immune status of patients undergoing such therapy." @default.
- W4290249136 created "2022-08-07" @default.
- W4290249136 creator A5004985653 @default.
- W4290249136 creator A5010041154 @default.
- W4290249136 creator A5015448519 @default.
- W4290249136 creator A5016475427 @default.
- W4290249136 creator A5021511067 @default.
- W4290249136 creator A5054182328 @default.
- W4290249136 date "1991-02-01" @default.
- W4290249136 modified "2023-09-29" @default.
- W4290249136 title "Effects of recombinant human granulocyte colony-stimulating factor on neutrophil function in vitro and in vivo following chemotherapy and autologous bone marrow transplantation." @default.
- W4290249136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1725883" @default.
- W4290249136 hasPublicationYear "1991" @default.
- W4290249136 type Work @default.
- W4290249136 citedByCount "3" @default.
- W4290249136 countsByYear W42902491362018 @default.
- W4290249136 crossrefType "journal-article" @default.
- W4290249136 hasAuthorship W4290249136A5004985653 @default.
- W4290249136 hasAuthorship W4290249136A5010041154 @default.
- W4290249136 hasAuthorship W4290249136A5015448519 @default.
- W4290249136 hasAuthorship W4290249136A5016475427 @default.
- W4290249136 hasAuthorship W4290249136A5021511067 @default.
- W4290249136 hasAuthorship W4290249136A5054182328 @default.
- W4290249136 hasConcept C109159458 @default.
- W4290249136 hasConcept C126322002 @default.
- W4290249136 hasConcept C150903083 @default.
- W4290249136 hasConcept C203014093 @default.
- W4290249136 hasConcept C207001950 @default.
- W4290249136 hasConcept C2776364478 @default.
- W4290249136 hasConcept C2776694085 @default.
- W4290249136 hasConcept C2777063308 @default.
- W4290249136 hasConcept C2777478134 @default.
- W4290249136 hasConcept C2777767877 @default.
- W4290249136 hasConcept C2777983669 @default.
- W4290249136 hasConcept C2778690821 @default.
- W4290249136 hasConcept C2779958370 @default.
- W4290249136 hasConcept C2780007613 @default.
- W4290249136 hasConcept C28328180 @default.
- W4290249136 hasConcept C2911091166 @default.
- W4290249136 hasConcept C54355233 @default.
- W4290249136 hasConcept C71924100 @default.
- W4290249136 hasConcept C74133956 @default.
- W4290249136 hasConcept C86803240 @default.
- W4290249136 hasConceptScore W4290249136C109159458 @default.
- W4290249136 hasConceptScore W4290249136C126322002 @default.
- W4290249136 hasConceptScore W4290249136C150903083 @default.
- W4290249136 hasConceptScore W4290249136C203014093 @default.
- W4290249136 hasConceptScore W4290249136C207001950 @default.
- W4290249136 hasConceptScore W4290249136C2776364478 @default.
- W4290249136 hasConceptScore W4290249136C2776694085 @default.
- W4290249136 hasConceptScore W4290249136C2777063308 @default.
- W4290249136 hasConceptScore W4290249136C2777478134 @default.
- W4290249136 hasConceptScore W4290249136C2777767877 @default.
- W4290249136 hasConceptScore W4290249136C2777983669 @default.
- W4290249136 hasConceptScore W4290249136C2778690821 @default.
- W4290249136 hasConceptScore W4290249136C2779958370 @default.
- W4290249136 hasConceptScore W4290249136C2780007613 @default.
- W4290249136 hasConceptScore W4290249136C28328180 @default.
- W4290249136 hasConceptScore W4290249136C2911091166 @default.
- W4290249136 hasConceptScore W4290249136C54355233 @default.
- W4290249136 hasConceptScore W4290249136C71924100 @default.
- W4290249136 hasConceptScore W4290249136C74133956 @default.
- W4290249136 hasConceptScore W4290249136C86803240 @default.
- W4290249136 hasIssue "2" @default.
- W4290249136 hasLocation W42902491361 @default.
- W4290249136 hasOpenAccess W4290249136 @default.
- W4290249136 hasPrimaryLocation W42902491361 @default.
- W4290249136 hasRelatedWork W1988612413 @default.
- W4290249136 hasRelatedWork W2005028516 @default.
- W4290249136 hasRelatedWork W2089309190 @default.
- W4290249136 hasRelatedWork W2155846504 @default.
- W4290249136 hasRelatedWork W2170963949 @default.
- W4290249136 hasRelatedWork W2249328782 @default.
- W4290249136 hasRelatedWork W2401200890 @default.
- W4290249136 hasRelatedWork W2410548550 @default.
- W4290249136 hasRelatedWork W2410712814 @default.
- W4290249136 hasRelatedWork W2415791902 @default.
- W4290249136 hasVolume "34" @default.
- W4290249136 isParatext "false" @default.
- W4290249136 isRetracted "false" @default.
- W4290249136 workType "article" @default.