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- W4290295497 abstract "In order to analyze the effect of the anticonvulsant diphenyl hydantoin (DPH) over the frequency of sister chromatid exchanges (SCE) in vivo, Balb-C mouse 8-12 weeks old, males and females, were injected intraperitoneally with a single dose and three different concentrations: 1, 10 and 20 mg/Kg, as negative and positive control, we used physiological serum and mitomycin-C respectively that were injected in the same way. Twenty five metaphases were analyzed per individual in the slide with the differential staining of sister chromatid, we found a light, but significantly increase, in the frequency of SCE in the concentrations of 10 and 20 mg/Kg when they were compared with the ones obtained for the negative control. In the males was observed a positive correlation in the levels of ICH when the doses of DPH were increased." @default.
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- W4290295497 date "1990-07-01" @default.
- W4290295497 modified "2023-09-26" @default.
- W4290295497 title "[Effect of sodium diphenylhydantoin on sister chromatid exchange frequency in mice]." @default.
- W4290295497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2131767" @default.
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