Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290375086> ?p ?o ?g. }
- W4290375086 endingPage "114645" @default.
- W4290375086 startingPage "114645" @default.
- W4290375086 abstract "N2,6-Substituted 1,3,5-triazine-2,4-diamines (N2-substituted guanamines) attracted significant interest due to their potential in the development of bioactive molecules. With just two points of diversity, this scaffold is proved to be suitable for constructing compounds targeting various enzymes, receptors, transporters, and nucleic acids with an array of therapeutic applications, particularly in cancer, inflammation, and CNS disorders. This review discusses progress in the synthesis of N2,6-substituted 1,3,5-triazine-2,4-diamines and their biological activities ranging from the inhibition of cancer-related enzymes (e.g. DNA topoisomerase IIα, carbonic anhydrases, ubiquitin-conjugating enzyme 2B, lysophosphatidic acid acyltransferase β and various kinases) to the binding to CNS-relevant receptors (e.g. histamine H4, serotonin 5-HT6, adenosine A2a, and α7 nicotinic acetylcholine receptors)." @default.
- W4290375086 created "2022-08-07" @default.
- W4290375086 creator A5001563551 @default.
- W4290375086 creator A5013827851 @default.
- W4290375086 date "2022-11-01" @default.
- W4290375086 modified "2023-09-30" @default.
- W4290375086 title "A closer look at N2,6-substituted 1,3,5-triazine-2,4-diamines: Advances in synthesis and biological activities" @default.
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