FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290391330> ?p ?o ?g. }

• W4290391330 endingPage "108290" @default.
• W4290391330 startingPage "108290" @default.
• W4290391330 abstract "An overexpression and upregulation has been observed in the activity of LIF in various cancers which leads to the worsening prognosis of numerous patients. Domain D5 of gp130 forms a crucial part of the downstream signalling pathway necessary for the activity of this cytokine. Due to the absence of any known inhibitors or previous studies conducted on this domain, this domain presents itself as a novel potential therapeutic target for the development of anti-cancer drugs. Here, an attempt has been made to discover one such potential lead drug candidate via the application of various computer-aided drug designing techniques. A natural plant products library was used along with known inhibitors of the STAT3 signalling pathway through which LIF exerts its activity. The ligand displaying the highest interaction with the target, a good docking score, and an optimal bioavailability was chosen. This ligand- ZINC02131250 forms a very strong complex with the target domain thatremains stable throughout the simulation period. Binding of the ligand to the target also results in an overall decrease in the domain's flexibility, free energy, and motion. Thus, this ligand can be taken for further testing using bioassays and then be used as a viable novel treatment for many cancer types." @default.
• W4290391330 created "2022-08-07" @default.
• W4290391330 creator A5001282764 @default.
• W4290391330 creator A5076718576 @default.
• W4290391330 date "2022-12-01" @default.
• W4290391330 modified "2023-09-29" @default.
• W4290391330 title "Targeting the gp130_D5 domain through pharmacophore modelling and structure-based virtual screening using natural plant products: A detailed molecular dynamics study for development of novel anti-cancer therapeutics" @default.
• W4290391330 cites W1420575482 @default.
• W4290391330 cites W1504928717 @default.
• W4290391330 cites W1519883000 @default.
• W4290391330 cites W1563136310 @default.
• W4290391330 cites W1624860839 @default.
• W4290391330 cites W1824670638 @default.
• W4290391330 cites W1975459052 @default.
• W4290391330 cites W1989521990 @default.
• W4290391330 cites W2002063031 @default.
• W4290391330 cites W2005109042 @default.
• W4290391330 cites W2028046413 @default.
• W4290391330 cites W2034052014 @default.
• W4290391330 cites W2056216573 @default.
• W4290391330 cites W2087064593 @default.
• W4290391330 cites W2091210644 @default.
• W4290391330 cites W2099001405 @default.
• W4290391330 cites W2101151845 @default.
• W4290391330 cites W2103734924 @default.
• W4290391330 cites W2109154308 @default.
• W4290391330 cites W2110777903 @default.
• W4290391330 cites W2119174526 @default.
• W4290391330 cites W2129209464 @default.
• W4290391330 cites W2169678694 @default.
• W4290391330 cites W2171268876 @default.
• W4290391330 cites W2292301738 @default.
• W4290391330 cites W2415258223 @default.
• W4290391330 cites W2593436234 @default.
• W4290391330 cites W2614495625 @default.
• W4290391330 cites W2617763968 @default.
• W4290391330 cites W2778765825 @default.
• W4290391330 cites W2790101413 @default.
• W4290391330 cites W2799321019 @default.
• W4290391330 cites W2799327292 @default.
• W4290391330 cites W2898264436 @default.
• W4290391330 cites W2970183286 @default.
• W4290391330 cites W2985222827 @default.
• W4290391330 cites W3040963041 @default.
• W4290391330 cites W3136918052 @default.
• W4290391330 doi "https://doi.org/10.1016/j.jmgm.2022.108290" @default.
• W4290391330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36029729" @default.
• W4290391330 hasPublicationYear "2022" @default.
• W4290391330 type Work @default.
• W4290391330 citedByCount "0" @default.
• W4290391330 crossrefType "journal-article" @default.
• W4290391330 hasAuthorship W4290391330A5001282764 @default.
• W4290391330 hasAuthorship W4290391330A5076718576 @default.
• W4290391330 hasConcept C103697762 @default.
• W4290391330 hasConcept C121608353 @default.
• W4290391330 hasConcept C159110408 @default.
• W4290391330 hasConcept C185592680 @default.
• W4290391330 hasConcept C2780035454 @default.
• W4290391330 hasConcept C41008148 @default.
• W4290391330 hasConcept C41685203 @default.
• W4290391330 hasConcept C54355233 @default.
• W4290391330 hasConcept C56173144 @default.
• W4290391330 hasConcept C60644358 @default.
• W4290391330 hasConcept C64903051 @default.
• W4290391330 hasConcept C70721500 @default.
• W4290391330 hasConcept C71924100 @default.
• W4290391330 hasConcept C74187038 @default.
• W4290391330 hasConcept C86803240 @default.
• W4290391330 hasConcept C98274493 @default.
• W4290391330 hasConceptScore W4290391330C103697762 @default.
• W4290391330 hasConceptScore W4290391330C121608353 @default.
• W4290391330 hasConceptScore W4290391330C159110408 @default.
• W4290391330 hasConceptScore W4290391330C185592680 @default.
• W4290391330 hasConceptScore W4290391330C2780035454 @default.
• W4290391330 hasConceptScore W4290391330C41008148 @default.
• W4290391330 hasConceptScore W4290391330C41685203 @default.
• W4290391330 hasConceptScore W4290391330C54355233 @default.
• W4290391330 hasConceptScore W4290391330C56173144 @default.
• W4290391330 hasConceptScore W4290391330C60644358 @default.
• W4290391330 hasConceptScore W4290391330C64903051 @default.
• W4290391330 hasConceptScore W4290391330C70721500 @default.
• W4290391330 hasConceptScore W4290391330C71924100 @default.
• W4290391330 hasConceptScore W4290391330C74187038 @default.
• W4290391330 hasConceptScore W4290391330C86803240 @default.
• W4290391330 hasConceptScore W4290391330C98274493 @default.
• W4290391330 hasFunder F4320320720 @default.
• W4290391330 hasLocation W42903913301 @default.
• W4290391330 hasLocation W42903913302 @default.
• W4290391330 hasOpenAccess W4290391330 @default.
• W4290391330 hasPrimaryLocation W42903913301 @default.
• W4290391330 hasRelatedWork W2012839858 @default.
• W4290391330 hasRelatedWork W2155762020 @default.
• W4290391330 hasRelatedWork W2158333076 @default.
• W4290391330 hasRelatedWork W2168561710 @default.
• W4290391330 hasRelatedWork W2546781214 @default.
• W4290391330 hasRelatedWork W2919126494 @default.
• W4290391330 hasRelatedWork W3207746690 @default.
• W4290391330 hasRelatedWork W4292552937 @default.

• next