Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290441073> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4290441073 endingPage "11" @default.
- W4290441073 startingPage "405" @default.
- W4290441073 abstract "Karyotypic analysis of 54 malignant human gliomas (5 anaplastic astrocytomas, 43 glioblastoma multiformes, 3 gliosarcomas, 2 giant cell glioblastomas, 1 anaplastic mixed glioma) has demonstrated that 12 tumors contained normal stemlines or only lacked one sex chromosome. The 42 tumors with abnormal karyotypes included 38 tumors which could be completely analyzed. Six of these 38 cases had near-triploid or near-tetraploid stemlines and 32 had near-diploid stemlines. Statistically significant numerical deviations in the near-diploid group were gains of chromosome 7 (26 of 32; P less than 0.001), and losses of chromosome 10 (19 of 32; P less than 0.001). Double minutes occurred in 18 of 32 near diploid tumors. The distribution of structural abnormalities was analyzed statistically by comparing the incidence of breakpoint in each chromosomal arm to the expected value based on chromosomal arm length. This analysis demonstrated that structural abnormalities of 9p and 19q were significant statistically (P less than 0.005 and P = 0.02, respectively). Although chromosome 1, 6p, the centromeric region of chromosome 11, 13q, and 15q were also frequently involved in structural abnormalities, the incidence of these breaks did not reach statistical significance. This demonstration of specific chromosomal abnormalities in near-diploid gliomas provides the basis for the investigation of genes which may be quantitatively or qualitatively altered in these neoplasms." @default.
- W4290441073 created "2022-08-07" @default.
- W4290441073 creator A5011739805 @default.
- W4290441073 creator A5022998598 @default.
- W4290441073 creator A5023114982 @default.
- W4290441073 creator A5040981192 @default.
- W4290441073 creator A5045187393 @default.
- W4290441073 creator A5052931422 @default.
- W4290441073 creator A5064217990 @default.
- W4290441073 date "1988-01-15" @default.
- W4290441073 modified "2023-09-29" @default.
- W4290441073 title "Specific chromosomal abnormalities in malignant human gliomas." @default.
- W4290441073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3335011" @default.
- W4290441073 hasPublicationYear "1988" @default.
- W4290441073 type Work @default.
- W4290441073 citedByCount "60" @default.
- W4290441073 countsByYear W42904410732012 @default.
- W4290441073 countsByYear W42904410732015 @default.
- W4290441073 countsByYear W42904410732016 @default.
- W4290441073 countsByYear W42904410732019 @default.
- W4290441073 countsByYear W42904410732020 @default.
- W4290441073 countsByYear W42904410732022 @default.
- W4290441073 countsByYear W42904410732023 @default.
- W4290441073 crossrefType "journal-article" @default.
- W4290441073 hasAuthorship W4290441073A5011739805 @default.
- W4290441073 hasAuthorship W4290441073A5022998598 @default.
- W4290441073 hasAuthorship W4290441073A5023114982 @default.
- W4290441073 hasAuthorship W4290441073A5040981192 @default.
- W4290441073 hasAuthorship W4290441073A5045187393 @default.
- W4290441073 hasAuthorship W4290441073A5052931422 @default.
- W4290441073 hasAuthorship W4290441073A5064217990 @default.
- W4290441073 hasConcept C104317684 @default.
- W4290441073 hasConcept C109748351 @default.
- W4290441073 hasConcept C120665830 @default.
- W4290441073 hasConcept C121332964 @default.
- W4290441073 hasConcept C138626823 @default.
- W4290441073 hasConcept C142724271 @default.
- W4290441073 hasConcept C143191323 @default.
- W4290441073 hasConcept C174475383 @default.
- W4290441073 hasConcept C206936463 @default.
- W4290441073 hasConcept C2778227246 @default.
- W4290441073 hasConcept C30481170 @default.
- W4290441073 hasConcept C53226629 @default.
- W4290441073 hasConcept C54355233 @default.
- W4290441073 hasConcept C61511704 @default.
- W4290441073 hasConcept C71924100 @default.
- W4290441073 hasConcept C86803240 @default.
- W4290441073 hasConceptScore W4290441073C104317684 @default.
- W4290441073 hasConceptScore W4290441073C109748351 @default.
- W4290441073 hasConceptScore W4290441073C120665830 @default.
- W4290441073 hasConceptScore W4290441073C121332964 @default.
- W4290441073 hasConceptScore W4290441073C138626823 @default.
- W4290441073 hasConceptScore W4290441073C142724271 @default.
- W4290441073 hasConceptScore W4290441073C143191323 @default.
- W4290441073 hasConceptScore W4290441073C174475383 @default.
- W4290441073 hasConceptScore W4290441073C206936463 @default.
- W4290441073 hasConceptScore W4290441073C2778227246 @default.
- W4290441073 hasConceptScore W4290441073C30481170 @default.
- W4290441073 hasConceptScore W4290441073C53226629 @default.
- W4290441073 hasConceptScore W4290441073C54355233 @default.
- W4290441073 hasConceptScore W4290441073C61511704 @default.
- W4290441073 hasConceptScore W4290441073C71924100 @default.
- W4290441073 hasConceptScore W4290441073C86803240 @default.
- W4290441073 hasIssue "2" @default.
- W4290441073 hasLocation W42904410731 @default.
- W4290441073 hasOpenAccess W4290441073 @default.
- W4290441073 hasPrimaryLocation W42904410731 @default.
- W4290441073 hasRelatedWork W1484593295 @default.
- W4290441073 hasRelatedWork W1491421164 @default.
- W4290441073 hasRelatedWork W1602193081 @default.
- W4290441073 hasRelatedWork W1980356048 @default.
- W4290441073 hasRelatedWork W2027830190 @default.
- W4290441073 hasRelatedWork W2030981806 @default.
- W4290441073 hasRelatedWork W2035686220 @default.
- W4290441073 hasRelatedWork W2074935018 @default.
- W4290441073 hasRelatedWork W2171218815 @default.
- W4290441073 hasRelatedWork W2411108492 @default.
- W4290441073 hasVolume "48" @default.
- W4290441073 isParatext "false" @default.
- W4290441073 isRetracted "false" @default.
- W4290441073 workType "article" @default.