FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290467437> ?p ?o ?g. }

• W4290467437 endingPage "1911" @default.
• W4290467437 startingPage "1911" @default.
• W4290467437 abstract "Positive surgical margins (PSM) after radical prostatectomy are associated with a greater risk of biochemical recurrence (BCR). However, not all PSM harbour the same prognosis for recurrence. We aim to determine the impact of different PSM characteristics and their coexistence on the risk of BCR. This retrospective study included 333 patients that underwent robotic-assisted radical prostatectomy for prostate cancer between 2015–2020 at a single institution. The effect of PSM and their adverse characteristics on the risk of BCR was assessed using Cox proportional hazard models. Kaplan–Meier was used to represent BCR-free survival stratified by margin status. With a median follow-up of 34.5 months, patients with PSM had a higher incidence of BCR, higher risk of relapse and lower BCR-free survival than negative margins (p < 0.001). We established as adverse characteristics: PSM length ≥ 3 mm, multifocality and Gleason at margin > 3. PSM ≥ 3 mm or multifocal PSM were associated with an increased risk for BCR compared to favourable margins (HR 3.50; 95% CI 2.05–5.95, p < 0.001 and HR 2.18; 95% CI 1.09–4.37, p = 0.028, respectively). The coexistence of these two adverse features in the PSM also conferred a higher risk for biochemical relapse and lower BCR-free survival. Adverse Gleason in the margin did not confer a higher risk for BCR than non-adverse margins in our models. We concluded that PSM are an independent predictor for BCR and that the presence of adverse characteristics, such as length and focality, and their coexistence in the PSM are associated with a greater risk of recurrence. Nevertheless, subclassifying PSM with adverse features did not enhance the model’s predictive performance in our cohort." @default.
• W4290467437 created "2022-08-08" @default.
• W4290467437 creator A5001340494 @default.
• W4290467437 creator A5003016520 @default.
• W4290467437 creator A5012855495 @default.
• W4290467437 creator A5022340695 @default.
• W4290467437 creator A5032406457 @default.
• W4290467437 creator A5034018980 @default.
• W4290467437 creator A5050388538 @default.
• W4290467437 creator A5081426277 @default.
• W4290467437 date "2022-08-07" @default.
• W4290467437 modified "2023-10-18" @default.
• W4290467437 title "The Effect of Adverse Surgical Margins on the Risk of Biochemical Recurrence after Robotic-Assisted Radical Prostatectomy" @default.
• W4290467437 cites W1529100377 @default.
• W4290467437 cites W1603562506 @default.
• W4290467437 cites W1980872978 @default.
• W4290467437 cites W1986392873 @default.
• W4290467437 cites W2008923710 @default.
• W4290467437 cites W2009319121 @default.
• W4290467437 cites W2022609321 @default.
• W4290467437 cites W2023903837 @default.
• W4290467437 cites W2026216375 @default.
• W4290467437 cites W2036610808 @default.
• W4290467437 cites W2044264567 @default.
• W4290467437 cites W2061872473 @default.
• W4290467437 cites W2080930072 @default.
• W4290467437 cites W2089305758 @default.
• W4290467437 cites W2100287343 @default.
• W4290467437 cites W2115408881 @default.
• W4290467437 cites W2130554884 @default.
• W4290467437 cites W2131074916 @default.
• W4290467437 cites W2140754632 @default.
• W4290467437 cites W2141710955 @default.
• W4290467437 cites W2148329056 @default.
• W4290467437 cites W2152529149 @default.
• W4290467437 cites W2156306108 @default.
• W4290467437 cites W2163764479 @default.
• W4290467437 cites W2164980194 @default.
• W4290467437 cites W2398084274 @default.
• W4290467437 cites W2528711443 @default.
• W4290467437 cites W2761944556 @default.
• W4290467437 cites W2771930122 @default.
• W4290467437 cites W2787801582 @default.
• W4290467437 cites W2809714745 @default.
• W4290467437 cites W2932369063 @default.
• W4290467437 cites W2974155634 @default.
• W4290467437 cites W2975356426 @default.
• W4290467437 cites W2979298239 @default.
• W4290467437 cites W3009221479 @default.
• W4290467437 cites W3087977689 @default.
• W4290467437 cites W3088103374 @default.
• W4290467437 cites W3088359655 @default.
• W4290467437 cites W3088633614 @default.
• W4290467437 cites W3097158220 @default.
• W4290467437 cites W3177116248 @default.
• W4290467437 cites W3186821748 @default.
• W4290467437 cites W3211228649 @default.
• W4290467437 cites W4220866674 @default.
• W4290467437 doi "https://doi.org/10.3390/biomedicines10081911" @default.
• W4290467437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36009458" @default.
• W4290467437 hasPublicationYear "2022" @default.
• W4290467437 type Work @default.
• W4290467437 citedByCount "1" @default.
• W4290467437 countsByYear W42904674372023 @default.
• W4290467437 crossrefType "journal-article" @default.
• W4290467437 hasAuthorship W4290467437A5001340494 @default.
• W4290467437 hasAuthorship W4290467437A5003016520 @default.
• W4290467437 hasAuthorship W4290467437A5012855495 @default.
• W4290467437 hasAuthorship W4290467437A5022340695 @default.
• W4290467437 hasAuthorship W4290467437A5032406457 @default.
• W4290467437 hasAuthorship W4290467437A5034018980 @default.
• W4290467437 hasAuthorship W4290467437A5050388538 @default.
• W4290467437 hasAuthorship W4290467437A5081426277 @default.
• W4290467437 hasBestOaLocation W42904674371 @default.
• W4290467437 hasConcept C121608353 @default.
• W4290467437 hasConcept C126322002 @default.
• W4290467437 hasConcept C126894567 @default.
• W4290467437 hasConcept C141071460 @default.
• W4290467437 hasConcept C143998085 @default.
• W4290467437 hasConcept C170493617 @default.
• W4290467437 hasConcept C197934379 @default.
• W4290467437 hasConcept C207103383 @default.
• W4290467437 hasConcept C2777008409 @default.
• W4290467437 hasConcept C2778913397 @default.
• W4290467437 hasConcept C2779466945 @default.
• W4290467437 hasConcept C2779668873 @default.
• W4290467437 hasConcept C2780192828 @default.
• W4290467437 hasConcept C43907098 @default.
• W4290467437 hasConcept C44249647 @default.
• W4290467437 hasConcept C50382708 @default.
• W4290467437 hasConcept C71924100 @default.
• W4290467437 hasConceptScore W4290467437C121608353 @default.
• W4290467437 hasConceptScore W4290467437C126322002 @default.
• W4290467437 hasConceptScore W4290467437C126894567 @default.
• W4290467437 hasConceptScore W4290467437C141071460 @default.
• W4290467437 hasConceptScore W4290467437C143998085 @default.
• W4290467437 hasConceptScore W4290467437C170493617 @default.
• W4290467437 hasConceptScore W4290467437C197934379 @default.

• next