FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290643076> ?p ?o ?g. }

• W4290643076 endingPage "1550" @default.
• W4290643076 startingPage "1543" @default.
• W4290643076 abstract "Abstract Objectives Copy number alterations (CNAs) are frequently found in malignant tissues. Different approaches have been used for CNA detection. However, it is not easy to detect a large panel of CNA targets in heterogenous tumors. Methods We have developed a CNAs detection approach through quantitatively analyzed allelic imbalance by allelotyping single nucleotide polymorphisms (SNPs) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Furthermore, the copy number changes were quantified by real-competitive PCR (rcPCR) to distinguish loss of heterozygosity (LOH) and genomic amplification. The approach was used to validate the CNA regions detected by next generation sequencing (NGS) in early-stage lung carcinoma. Results CNAs were detected in heterogeneous DNA samples where tumor DNA is present at only 10% through the SNP based allelotyping. In addition, two different types of CNAs (loss of heterozygosity and chromosome amplification) were able to be distinguished quantitatively by rcPCR. Validation on a total of 41 SNPs from the selected CNA regions showed that copy number changes did occur, and the tissues from early-stage lung carcinoma were distinguished from normal. Conclusions CNA detection by MALDI-TOF MS can be used for validating potentially interesting genomic regions identified from next generation sequencing, and for detecting CNAs in tumor tissues consisting of a mixture of neoplastic and normal cells." @default.
• W4290643076 created "2022-08-08" @default.
• W4290643076 creator A5044828742 @default.
• W4290643076 creator A5045185553 @default.
• W4290643076 creator A5063684554 @default.
• W4290643076 creator A5065196034 @default.
• W4290643076 creator A5067449384 @default.
• W4290643076 creator A5070428783 @default.
• W4290643076 creator A5072737130 @default.
• W4290643076 creator A5079698078 @default.
• W4290643076 creator A5085948587 @default.
• W4290643076 creator A5090325393 @default.
• W4290643076 creator A5091663525 @default.
• W4290643076 date "2022-08-08" @default.
• W4290643076 modified "2023-09-26" @default.
• W4290643076 title "Detection of DNA copy number alterations by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of single nucleotide polymorphisms" @default.
• W4290643076 cites W1512173429 @default.
• W4290643076 cites W1968046362 @default.
• W4290643076 cites W1971034474 @default.
• W4290643076 cites W1980538880 @default.
• W4290643076 cites W1980847511 @default.
• W4290643076 cites W1983348452 @default.
• W4290643076 cites W1990852721 @default.
• W4290643076 cites W1994655768 @default.
• W4290643076 cites W1999665897 @default.
• W4290643076 cites W2001627828 @default.
• W4290643076 cites W2009111704 @default.
• W4290643076 cites W2009978569 @default.
• W4290643076 cites W2031601064 @default.
• W4290643076 cites W2048749946 @default.
• W4290643076 cites W2056120923 @default.
• W4290643076 cites W2056121212 @default.
• W4290643076 cites W2058080192 @default.
• W4290643076 cites W2059297225 @default.
• W4290643076 cites W2071387002 @default.
• W4290643076 cites W2076544181 @default.
• W4290643076 cites W2079480494 @default.
• W4290643076 cites W2085022319 @default.
• W4290643076 cites W2088245621 @default.
• W4290643076 cites W2091600938 @default.
• W4290643076 cites W2096206246 @default.
• W4290643076 cites W2099742439 @default.
• W4290643076 cites W2107966042 @default.
• W4290643076 cites W2108952260 @default.
• W4290643076 cites W2114553186 @default.
• W4290643076 cites W2120793026 @default.
• W4290643076 cites W2132819133 @default.
• W4290643076 cites W2145438889 @default.
• W4290643076 cites W2206425763 @default.
• W4290643076 cites W2405513305 @default.
• W4290643076 cites W2605109614 @default.
• W4290643076 cites W2742981122 @default.
• W4290643076 cites W2900061323 @default.
• W4290643076 cites W2952892955 @default.
• W4290643076 cites W2965428924 @default.
• W4290643076 cites W2989571119 @default.
• W4290643076 cites W3131586948 @default.
• W4290643076 cites W3185053431 @default.
• W4290643076 cites W4323253135 @default.
• W4290643076 cites W2120374840 @default.
• W4290643076 doi "https://doi.org/10.1515/cclm-2022-0511" @default.
• W4290643076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35938948" @default.
• W4290643076 hasPublicationYear "2022" @default.
• W4290643076 type Work @default.
• W4290643076 citedByCount "1" @default.
• W4290643076 countsByYear W42906430762022 @default.
• W4290643076 crossrefType "journal-article" @default.
• W4290643076 hasAuthorship W4290643076A5044828742 @default.
• W4290643076 hasAuthorship W4290643076A5045185553 @default.
• W4290643076 hasAuthorship W4290643076A5063684554 @default.
• W4290643076 hasAuthorship W4290643076A5065196034 @default.
• W4290643076 hasAuthorship W4290643076A5067449384 @default.
• W4290643076 hasAuthorship W4290643076A5070428783 @default.
• W4290643076 hasAuthorship W4290643076A5072737130 @default.
• W4290643076 hasAuthorship W4290643076A5079698078 @default.
• W4290643076 hasAuthorship W4290643076A5085948587 @default.
• W4290643076 hasAuthorship W4290643076A5090325393 @default.
• W4290643076 hasAuthorship W4290643076A5091663525 @default.
• W4290643076 hasConcept C104317684 @default.
• W4290643076 hasConcept C120821319 @default.
• W4290643076 hasConcept C122060243 @default.
• W4290643076 hasConcept C135763542 @default.
• W4290643076 hasConcept C141231307 @default.
• W4290643076 hasConcept C143589142 @default.
• W4290643076 hasConcept C153209595 @default.
• W4290643076 hasConcept C153911025 @default.
• W4290643076 hasConcept C162356407 @default.
• W4290643076 hasConcept C17757408 @default.
• W4290643076 hasConcept C180754005 @default.
• W4290643076 hasConcept C185592680 @default.
• W4290643076 hasConcept C43617362 @default.
• W4290643076 hasConcept C502942594 @default.
• W4290643076 hasConcept C51679486 @default.
• W4290643076 hasConcept C54355233 @default.
• W4290643076 hasConcept C552990157 @default.
• W4290643076 hasConcept C86803240 @default.
• W4290643076 hasConceptScore W4290643076C104317684 @default.
• W4290643076 hasConceptScore W4290643076C120821319 @default.

• next