Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290647400> ?p ?o ?g. }
- W4290647400 endingPage "205" @default.
- W4290647400 startingPage "196" @default.
- W4290647400 abstract "CRISPR-Cas systems play a critical role in the prokaryotic adaptive immunity against mobile genetic elements, such as phages and foreign plasmids. In the last decade, Cas9 has been established as a powerful and versatile gene editing tool. In its wake, the novel RNA-guided endonuclease system CRISPR-Cas12a is transforming biological research due to its unique properties, such as its high specificity or its ability to target T-rich motifs, to induce staggered double-strand breaks and to process RNA arrays. Meanwhile, there is an increasing need for efficient and safe gene activation, repression or editing in pluricellular organisms for crop improvement, gene therapy, research model development, and other goals. In this article, we review CRISPR-Cas12a applications in pluricellular organisms and discuss how the challenges characteristic of these complex models, such as vectorization or temperature variations in ectothermic species, can be overcome." @default.
- W4290647400 created "2022-08-08" @default.
- W4290647400 creator A5067687885 @default.
- W4290647400 creator A5078154783 @default.
- W4290647400 date "2022-08-08" @default.
- W4290647400 modified "2023-10-16" @default.
- W4290647400 title "Current and Prospective Applications of CRISPR-Cas12a in Pluricellular Organisms" @default.
- W4290647400 cites W1995920076 @default.
- W4290647400 cites W2045435533 @default.
- W4290647400 cites W2076785026 @default.
- W4290647400 cites W2095624846 @default.
- W4290647400 cites W2131157113 @default.
- W4290647400 cites W2165869860 @default.
- W4290647400 cites W2341405505 @default.
- W4290647400 cites W2409121249 @default.
- W4290647400 cites W2410526873 @default.
- W4290647400 cites W2412316478 @default.
- W4290647400 cites W2465120080 @default.
- W4290647400 cites W2513453849 @default.
- W4290647400 cites W2515623196 @default.
- W4290647400 cites W2550769902 @default.
- W4290647400 cites W2560230043 @default.
- W4290647400 cites W2586002364 @default.
- W4290647400 cites W2588570791 @default.
- W4290647400 cites W2588577496 @default.
- W4290647400 cites W2597038011 @default.
- W4290647400 cites W2607120679 @default.
- W4290647400 cites W2607389813 @default.
- W4290647400 cites W2623277795 @default.
- W4290647400 cites W2761794675 @default.
- W4290647400 cites W2766697866 @default.
- W4290647400 cites W2787024379 @default.
- W4290647400 cites W2793374681 @default.
- W4290647400 cites W2797474041 @default.
- W4290647400 cites W2800176137 @default.
- W4290647400 cites W2803295557 @default.
- W4290647400 cites W2804566227 @default.
- W4290647400 cites W2906020659 @default.
- W4290647400 cites W2913819746 @default.
- W4290647400 cites W2915013877 @default.
- W4290647400 cites W2917719112 @default.
- W4290647400 cites W2917919793 @default.
- W4290647400 cites W2918567627 @default.
- W4290647400 cites W2919923263 @default.
- W4290647400 cites W2934972609 @default.
- W4290647400 cites W2938360944 @default.
- W4290647400 cites W2944338776 @default.
- W4290647400 cites W2949423058 @default.
- W4290647400 cites W2949446120 @default.
- W4290647400 cites W2952898285 @default.
- W4290647400 cites W2963358556 @default.
- W4290647400 cites W2966725452 @default.
- W4290647400 cites W3008780987 @default.
- W4290647400 cites W3011791788 @default.
- W4290647400 cites W3026872952 @default.
- W4290647400 cites W3029817778 @default.
- W4290647400 cites W3038616757 @default.
- W4290647400 cites W3040362029 @default.
- W4290647400 cites W3043414469 @default.
- W4290647400 cites W3080957535 @default.
- W4290647400 cites W3082947798 @default.
- W4290647400 cites W3087072327 @default.
- W4290647400 cites W3087417143 @default.
- W4290647400 cites W3087540537 @default.
- W4290647400 cites W3125623881 @default.
- W4290647400 cites W3134397756 @default.
- W4290647400 cites W3148105589 @default.
- W4290647400 cites W3151488504 @default.
- W4290647400 cites W3155046225 @default.
- W4290647400 cites W3157150377 @default.
- W4290647400 cites W3163825845 @default.
- W4290647400 cites W3186987057 @default.
- W4290647400 cites W3201209487 @default.
- W4290647400 cites W3205261905 @default.
- W4290647400 cites W3206603599 @default.
- W4290647400 cites W4220783697 @default.
- W4290647400 cites W4245053291 @default.
- W4290647400 cites W2958904250 @default.
- W4290647400 doi "https://doi.org/10.1007/s12033-022-00538-5" @default.
- W4290647400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35939208" @default.
- W4290647400 hasPublicationYear "2022" @default.
- W4290647400 type Work @default.
- W4290647400 citedByCount "4" @default.
- W4290647400 countsByYear W42906474002023 @default.
- W4290647400 crossrefType "journal-article" @default.
- W4290647400 hasAuthorship W4290647400A5067687885 @default.
- W4290647400 hasAuthorship W4290647400A5078154783 @default.
- W4290647400 hasBestOaLocation W42906474001 @default.
- W4290647400 hasConcept C104317684 @default.
- W4290647400 hasConcept C132455925 @default.
- W4290647400 hasConcept C132533263 @default.
- W4290647400 hasConcept C144501496 @default.
- W4290647400 hasConcept C22744801 @default.
- W4290647400 hasConcept C54355233 @default.
- W4290647400 hasConcept C70721500 @default.
- W4290647400 hasConcept C84356384 @default.
- W4290647400 hasConcept C86803240 @default.
- W4290647400 hasConcept C98108389 @default.