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- W4290653851 endingPage "C822" @default.
- W4290653851 startingPage "C813" @default.
- W4290653851 abstract "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is well understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In the former, stimulation of Gs-coupled receptors leads to increases in contractility, whereas stimulation of Gq-coupled receptors modulates cellular survival and hypertrophic responses. In VSMCs, stimulation of GPCRs also modulates contractile and cell growth phenotypes. Here, we will focus on the relatively less well-studied effects of GPCRs in cardiac fibroblasts, focusing on key signaling events involved in the activation and differentiation of these cells. We also review the hierarchy of signaling events driving the fibrotic response and the communications between fibroblasts and other cells in the heart. We discuss how such events may be distinct depending on where the GPCRs and their associated signaling machinery are localized in these cells with an emphasis on nuclear membrane-localized receptors. Finally, we explore what such connections between the cell surface and nuclear GPCR signaling might mean for cardiac fibrosis." @default.
- W4290653851 created "2022-08-08" @default.
- W4290653851 creator A5001510201 @default.
- W4290653851 creator A5006175603 @default.
- W4290653851 creator A5010325981 @default.
- W4290653851 creator A5021824403 @default.
- W4290653851 creator A5052328017 @default.
- W4290653851 date "2022-09-01" @default.
- W4290653851 modified "2023-10-16" @default.
- W4290653851 title "The complicated lives of GPCRs in cardiac fibroblasts" @default.
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