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• W4290673638 endingPage "S46" @default.
• W4290673638 startingPage "S36" @default.
• W4290673638 abstract "Abstract Context Thyroid eye disease (TED) is a sight-threatening and debilitating autoimmune condition, with limited therapies available, that often poses diagnostic and therapeutic challenges. In recent years, the treatment landscape has shifted to early intervention with targeted therapy. Methods A PubMed review of the literature was conducted for the period between 1979 and 2021. Search terms included thyroid eye disease, teprotumumab, targeted therapy, Graves disease, Graves ophthalmopathy, dysthyroid optic neuropathy, and related terms in different combinations. Novel biologic therapies for TED have emerged as alternatives to traditional steroid regimens in recent years. New insights into TED pathophysiology have uncovered the role of the insulin-like growth factor 1 receptor (IGF-1R) and led to the development of teprotumumab, an IGF-1R–inhibiting monoclonal antibody. Results Randomized clinical trials demonstrating the efficacy of teprotumumab for TED led to Food and Drug Administration approval. Teprotumumab is gradually replacing immunosuppressive agents as first-line therapy in the United States for active moderate-to-severe TED, while emerging reports also show its use in other stages of the disease. Recent data highlight risk factors for adverse events and screening protocols to maximize patient safety. Personalized therapeutic plans developed through effective partnership between endocrinologists and ophthalmologists aim to enhance the safety and outcomes of TED treatments and improve care for this complex disease. Conclusion TED management is shifting to an era of targeted therapy with multidisciplinary care. Teprotumumab has demonstrated superior efficacy to conventional treatments and has transformed our therapeutic and surgical algorithms. Clinical guidelines and additional studies are needed to further guide and refine therapy." @default.
• W4290673638 created "2022-08-08" @default.
• W4290673638 creator A5006164328 @default.
• W4290673638 creator A5038476807 @default.
• W4290673638 creator A5081619954 @default.
• W4290673638 date "2022-08-08" @default.
• W4290673638 modified "2023-10-17" @default.
• W4290673638 title "Teprotumumab and the Evolving Therapeutic Landscape in Thyroid Eye Disease" @default.
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• W4290673638 doi "https://doi.org/10.1210/clinem/dgac168" @default.
• W4290673638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36346685" @default.
• W4290673638 hasPublicationYear "2022" @default.
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