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• W4290673668 abstract "SIGNAL is a multicenter, randomized, double-blind, placebo-controlled phase 2 study (no. NCT02481674) established to evaluate pepinemab, a semaphorin 4D (SEMA4D)-blocking antibody, for treatment of Huntington's disease (HD). The trial enrolled a total of 265 HD gene expansion carriers with either early manifest (EM, n = 179) or late prodromal (LP, n = 86) HD, randomized (1:1) to receive 18 monthly infusions of pepinemab (n = 91 EM, 41 LP) or placebo (n = 88 EM, 45 LP). Pepinemab was generally well tolerated, with a relatively low frequency of serious treatment-emergent adverse events of 5% with pepinemab compared to 9% with placebo, including both EM and LP participants. Coprimary efficacy outcome measures consisted of assessments within the EM cohort of (1) a two-item HD cognitive assessment family comprising one-touch stockings of Cambridge (OTS) and paced tapping (PTAP) and (2) clinical global impression of change (CGIC). The differences between pepinemab and placebo in mean change (95% confidence interval) from baseline at month 17 for OTS were -1.98 (-4.00, 0.05) (one-sided P = 0.028), and for PTAP 1.43 (-0.37, 3.23) (one-sided P = 0.06). Similarly, because a significant treatment effect was not observed for CGIC, the coprimary endpoint, the study did not meet its prespecified primary outcomes. Nevertheless, a number of other positive outcomes and post hoc subgroup analyses-including additional cognitive measures and volumetric magnetic resonance imaging and fluorodeoxyglucose-positron-emission tomography imaging assessments-provide rationale and direction for the design of a phase 3 study and encourage the continued development of pepinemab in patients diagnosed with EM HD." @default.
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• W4290673668 date "2022-08-08" @default.
• W4290673668 modified "2023-10-16" @default.
• W4290673668 title "Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial" @default.
• W4290673668 cites W1962375139 @default.
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• W4290673668 cites W1969736828 @default.
• W4290673668 cites W1970090890 @default.
• W4290673668 cites W1982132176 @default.
• W4290673668 cites W1984113570 @default.
• W4290673668 cites W1995012532 @default.
• W4290673668 cites W2000555003 @default.
• W4290673668 cites W2000877519 @default.
• W4290673668 cites W2002875429 @default.
• W4290673668 cites W2015602829 @default.
• W4290673668 cites W2020391568 @default.
• W4290673668 cites W2026618938 @default.
• W4290673668 cites W2028349138 @default.
• W4290673668 cites W2032120877 @default.
• W4290673668 cites W2038319340 @default.
• W4290673668 cites W2047195263 @default.
• W4290673668 cites W2055613750 @default.
• W4290673668 cites W2057332541 @default.
• W4290673668 cites W2062454002 @default.
• W4290673668 cites W2075565242 @default.
• W4290673668 cites W2081840097 @default.
• W4290673668 cites W2085044325 @default.
• W4290673668 cites W2113661629 @default.
• W4290673668 cites W2114151173 @default.
• W4290673668 cites W2114609710 @default.
• W4290673668 cites W2115012618 @default.
• W4290673668 cites W2121065286 @default.
• W4290673668 cites W2124063051 @default.
• W4290673668 cites W2124660038 @default.
• W4290673668 cites W2129250133 @default.
• W4290673668 cites W2148083007 @default.
• W4290673668 cites W2149756088 @default.
• W4290673668 cites W2155277084 @default.
• W4290673668 cites W2158763379 @default.
• W4290673668 cites W2171051269 @default.
• W4290673668 cites W2178772862 @default.
• W4290673668 cites W2186799344 @default.
• W4290673668 cites W2259830546 @default.
• W4290673668 cites W2290984097 @default.
• W4290673668 cites W2324158141 @default.
• W4290673668 cites W2510729468 @default.

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