Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290682194> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4290682194 endingPage "88" @default.
- W4290682194 startingPage "211" @default.
- W4290682194 abstract "Platelets do not adhere to surfaces to which flowing blood is normally exposed in vivo. When the lining of a blood vessel is altered or damaged, however, platelets do adhere to the injured site. Platelet adhesion is one of the first events in the formation of hemostatic plugs and thrombi, and plays a part in the development of atherosclerotic lesions. Other surfaces to which platelets adhere include particulate matter in the blood stream, bacteria and other microorganisms, the artificial surfaces of prosthetic devices, and some altered cells in the blood, particularly macrophages. The majority of investigators have studied the interaction of platelets with the subendothelium of normal vessels of young animals, or with isolated vessel wall constituents such as collagen. There are very few studies of platelet adhesion to repeatedly damaged or diseased blood vessels, although it is generally assumed that platelets interact with the connective tissue, fibrin, and cholesterol crystals in atherosclerotic lesions. Underlying the endothelium of blood vessel is the basement membrane, which has been shown to contain type IV collagen, elastin with its associated microfibrils, von Willebrand Factor, fibronectin, thrombospondin, laminin, and heparan sulfate. If only the endothelium is removed, the main structure exposed is the basement membrane with its associated proteins, but deeper injuries expose fibrillar type III collagen and microfibrils. In most studies in which large arteries have been injured by passage of a balloon catheter, basement membrane, type III collagen and the microfibrils around elastin have been exposed. Platelets do not react strongly with basement membrane and the type IV collagen in it is relatively inert. In contrast, platelets adhere firmly to type III (and type I) collagen and spread on it. Although in vitro studies have shown that platelets can interact with collagen in artificial media without plasma proteins, investigations of platelet adhesion at high shear rates indicate that von Willebrand Factor is necessary for firm platelet adhesion under these conditions. Fibronectin and thrombospondin may also have a role in platelet adhesion. However, platelets do not bind von Willebrand Factor or fibronectin until the platelets have been stimulated to release their granule contents, so these binding sites probably do not become available until the platelets have interacted with collagen or another release-inducing agent such as thrombin.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
- W4290682194 created "2022-08-08" @default.
- W4290682194 creator A5025642344 @default.
- W4290682194 creator A5079507627 @default.
- W4290682194 date "1984-01-01" @default.
- W4290682194 modified "2023-09-29" @default.
- W4290682194 title "Platelet adhesion." @default.
- W4290682194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6397767" @default.
- W4290682194 hasPublicationYear "1984" @default.
- W4290682194 type Work @default.
- W4290682194 citedByCount "9" @default.
- W4290682194 countsByYear W42906821942015 @default.
- W4290682194 countsByYear W42906821942017 @default.
- W4290682194 countsByYear W42906821942022 @default.
- W4290682194 crossrefType "journal-article" @default.
- W4290682194 hasAuthorship W4290682194A5025642344 @default.
- W4290682194 hasAuthorship W4290682194A5079507627 @default.
- W4290682194 hasConcept C134018914 @default.
- W4290682194 hasConcept C142724271 @default.
- W4290682194 hasConcept C185592680 @default.
- W4290682194 hasConcept C189165786 @default.
- W4290682194 hasConcept C203014093 @default.
- W4290682194 hasConcept C2776193487 @default.
- W4290682194 hasConcept C2776992346 @default.
- W4290682194 hasConcept C2779394231 @default.
- W4290682194 hasConcept C2779814568 @default.
- W4290682194 hasConcept C2779869378 @default.
- W4290682194 hasConcept C2780009322 @default.
- W4290682194 hasConcept C2993802102 @default.
- W4290682194 hasConcept C54173615 @default.
- W4290682194 hasConcept C55493867 @default.
- W4290682194 hasConcept C71924100 @default.
- W4290682194 hasConcept C86492073 @default.
- W4290682194 hasConcept C86803240 @default.
- W4290682194 hasConcept C89560881 @default.
- W4290682194 hasConcept C95444343 @default.
- W4290682194 hasConceptScore W4290682194C134018914 @default.
- W4290682194 hasConceptScore W4290682194C142724271 @default.
- W4290682194 hasConceptScore W4290682194C185592680 @default.
- W4290682194 hasConceptScore W4290682194C189165786 @default.
- W4290682194 hasConceptScore W4290682194C203014093 @default.
- W4290682194 hasConceptScore W4290682194C2776193487 @default.
- W4290682194 hasConceptScore W4290682194C2776992346 @default.
- W4290682194 hasConceptScore W4290682194C2779394231 @default.
- W4290682194 hasConceptScore W4290682194C2779814568 @default.
- W4290682194 hasConceptScore W4290682194C2779869378 @default.
- W4290682194 hasConceptScore W4290682194C2780009322 @default.
- W4290682194 hasConceptScore W4290682194C2993802102 @default.
- W4290682194 hasConceptScore W4290682194C54173615 @default.
- W4290682194 hasConceptScore W4290682194C55493867 @default.
- W4290682194 hasConceptScore W4290682194C71924100 @default.
- W4290682194 hasConceptScore W4290682194C86492073 @default.
- W4290682194 hasConceptScore W4290682194C86803240 @default.
- W4290682194 hasConceptScore W4290682194C89560881 @default.
- W4290682194 hasConceptScore W4290682194C95444343 @default.
- W4290682194 hasLocation W42906821941 @default.
- W4290682194 hasOpenAccess W4290682194 @default.
- W4290682194 hasPrimaryLocation W42906821941 @default.
- W4290682194 hasRelatedWork W169704349 @default.
- W4290682194 hasRelatedWork W1842693293 @default.
- W4290682194 hasRelatedWork W1982586273 @default.
- W4290682194 hasRelatedWork W2024123680 @default.
- W4290682194 hasRelatedWork W2071614606 @default.
- W4290682194 hasRelatedWork W2106370 @default.
- W4290682194 hasRelatedWork W2106761248 @default.
- W4290682194 hasRelatedWork W2362399350 @default.
- W4290682194 hasRelatedWork W2415881247 @default.
- W4290682194 hasRelatedWork W3017022832 @default.
- W4290682194 hasVolume "7" @default.
- W4290682194 isParatext "false" @default.
- W4290682194 isRetracted "false" @default.
- W4290682194 workType "article" @default.