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- W4290692586 abstract "Abstract Ebola virus is the primary contributor to the global threat of filovirus severe hemorrhagic fever, and Ebola virus disease has a case fatality rate of 50-90%. An inactivated, bivalent filovirus/Rabies virus vaccine, FILORAB1, consists of recombinant Rabies virus virions expressing the Ebola virus glycoprotein. FILORAB1 is immunogenic and protective from Ebola virus challenge in mice and non-human primates, and protection is enhanced when formulated with toll-like receptor 4 agonist Glucopyranosyl lipid adjuvant (GLA) in a squalene oil-in-water emulsion (SE). Through an adjuvant comparison in mice, we demonstrate that GLA-SE improves FILORAB1 efficacy by activating the innate immune system and shaping a Th1-biased adaptive immune response. GLA-SE adjuvanted mice and those adjuvanted with the SE component are better protected from surrogate challenge, while Th2 alum adjuvanted mice are not. Additionally, the immune response to FILORAB1 is long-lasting, as exhibited by highly-maintained serum antibody titers and long-lived cells in the spleen and bone marrow." @default.
- W4290692586 created "2022-08-09" @default.
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- W4290692586 date "2022-08-08" @default.
- W4290692586 modified "2023-10-02" @default.
- W4290692586 title "Effects of adjuvants on protection in a rabies-vectored Ebola virus vaccine" @default.
- W4290692586 doi "https://doi.org/10.21203/rs.3.rs-1917731/v1" @default.
- W4290692586 hasPublicationYear "2022" @default.
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