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- W4290703669 endingPage "1052" @default.
- W4290703669 startingPage "1052" @default.
- W4290703669 abstract "Major depressive disorder is a leading cause of disability and suicide worldwide. Consecutive rounds of conventional interventions are ineffective in a significant sub-group of patients whose disorder is classified as treatment-resistant depression. Significant progress in managing this severe form of depression has been achieved through the use of deep brain stimulation of the medial forebrain bundle (MFB). The beneficial effect of such stimulation appears strong, safe, and enduring. The proposed neural substrate for this promising clinical finding includes midbrain dopamine neurons and a subset of their cortical afferents. Here, we aim to broaden the discussion of the candidate circuitry by exploring potential implications of a new convergence model of brain reward circuitry in rodents. We chart the evolution of the new model from its predecessors, which held that midbrain dopamine neurons constituted an obligatory stage of the final common path for reward seeking. In contrast, the new model includes a directly activated, non-dopaminergic pathway whose output ultimately converges with that of the dopaminergic neurons. On the basis of the new model and the relative ineffectiveness of dopamine agonists in the treatment of depression, we ask whether non-dopaminergic circuitry may contribute to the clinical efficacy of deep brain stimulation of the MFB." @default.
- W4290703669 created "2022-08-09" @default.
- W4290703669 creator A5020070948 @default.
- W4290703669 creator A5078313513 @default.
- W4290703669 date "2022-08-08" @default.
- W4290703669 modified "2023-09-26" @default.
- W4290703669 title "Dopamine and Beyond: Implications of Psychophysical Studies of Intracranial Self-Stimulation for the Treatment of Depression" @default.
- W4290703669 cites W1747997349 @default.
- W4290703669 cites W1886006583 @default.
- W4290703669 cites W1963578854 @default.
- W4290703669 cites W1972170088 @default.
- W4290703669 cites W1976772594 @default.
- W4290703669 cites W1979001814 @default.
- W4290703669 cites W1988209588 @default.
- W4290703669 cites W1988343602 @default.
- W4290703669 cites W1989783934 @default.
- W4290703669 cites W1989987423 @default.
- W4290703669 cites W1990680291 @default.
- W4290703669 cites W1997128521 @default.
- W4290703669 cites W2002834809 @default.
- W4290703669 cites W2004118951 @default.
- W4290703669 cites W2005557049 @default.
- W4290703669 cites W2011911998 @default.
- W4290703669 cites W2012689624 @default.
- W4290703669 cites W2015710294 @default.
- W4290703669 cites W2024714506 @default.
- W4290703669 cites W2025440394 @default.
- W4290703669 cites W2025653751 @default.
- W4290703669 cites W2027853840 @default.
- W4290703669 cites W2028851681 @default.
- W4290703669 cites W2029504248 @default.
- W4290703669 cites W2030429571 @default.
- W4290703669 cites W2032363396 @default.
- W4290703669 cites W2036789119 @default.
- W4290703669 cites W2046081005 @default.
- W4290703669 cites W2047494050 @default.
- W4290703669 cites W2051933342 @default.
- W4290703669 cites W2052011218 @default.
- W4290703669 cites W2052108119 @default.
- W4290703669 cites W2053093248 @default.
- W4290703669 cites W2053529632 @default.
- W4290703669 cites W2053913132 @default.
- W4290703669 cites W2054466443 @default.
- W4290703669 cites W2055016516 @default.
- W4290703669 cites W2055124912 @default.
- W4290703669 cites W2057984172 @default.
- W4290703669 cites W2059033731 @default.
- W4290703669 cites W2063604509 @default.
- W4290703669 cites W2063640164 @default.
- W4290703669 cites W2064859797 @default.
- W4290703669 cites W2068807485 @default.
- W4290703669 cites W2071046540 @default.
- W4290703669 cites W2074669819 @default.
- W4290703669 cites W2076818678 @default.
- W4290703669 cites W2077655894 @default.
- W4290703669 cites W2079351204 @default.
- W4290703669 cites W2089074925 @default.
- W4290703669 cites W2091997345 @default.
- W4290703669 cites W2093366423 @default.
- W4290703669 cites W2095024126 @default.
- W4290703669 cites W2103857504 @default.
- W4290703669 cites W2109234696 @default.
- W4290703669 cites W2113449040 @default.
- W4290703669 cites W2115601524 @default.
- W4290703669 cites W2120959601 @default.
- W4290703669 cites W2123089523 @default.
- W4290703669 cites W2124480078 @default.
- W4290703669 cites W2133445800 @default.
- W4290703669 cites W2144312659 @default.
- W4290703669 cites W2146738944 @default.
- W4290703669 cites W2157766053 @default.
- W4290703669 cites W2159202946 @default.
- W4290703669 cites W2161773156 @default.
- W4290703669 cites W2164531443 @default.
- W4290703669 cites W2168795031 @default.
- W4290703669 cites W2312263068 @default.
- W4290703669 cites W2461298710 @default.
- W4290703669 cites W2547613528 @default.
- W4290703669 cites W2641079078 @default.
- W4290703669 cites W2809229523 @default.
- W4290703669 cites W2899633401 @default.
- W4290703669 cites W2899962782 @default.
- W4290703669 cites W2906034042 @default.
- W4290703669 cites W2919513253 @default.
- W4290703669 cites W2922385364 @default.
- W4290703669 cites W2953777207 @default.
- W4290703669 cites W2971521406 @default.
- W4290703669 cites W2981767691 @default.
- W4290703669 cites W3007058247 @default.
- W4290703669 cites W3034156586 @default.
- W4290703669 cites W3044679380 @default.
- W4290703669 cites W3045916251 @default.
- W4290703669 cites W3087409554 @default.
- W4290703669 cites W3092849554 @default.
- W4290703669 cites W3159528841 @default.
- W4290703669 cites W3163151906 @default.
- W4290703669 cites W3175964086 @default.
- W4290703669 cites W3197239493 @default.