Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290704908> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4290704908 endingPage "424" @default.
- W4290704908 startingPage "407" @default.
- W4290704908 abstract "Toxic Epidermal Necrolysis is a rare dermatological condition with high mortality and serious consequences on its survivors. Despite having been first described in 1956, its pathophysiology remains uncertain, mainly regarding its mechanisms, although it seems that certain apoptosis pathways are pivotal in starting keratinocytes’ apoptosis and in activating T cells, especially those mediated by tumour necrosis factor, Fas-FasL and granulysin. In general, its aetiology and presentation are consensual, being defined as a generalized necrolysis of the epidermis that occurs as an uncontrolled immune response to a specific drug or one of its metabolites, highlighting cotrimoxazole and allopurinol as the most important. This necrolysis leads to a massive shedding of the epidermal layer of the skin, with stronger incidences in the torso, upper limbs and face. Its complications tend to be severe, noting that septic ones are responsible for over half of the disease’s mortality. Nearly all survivors develop long-term sequelae, namely hypertrophic scarring and skin pigmentation anomalies. Regarding treatment, many different opinions arise, including contradictory ones, regarding more importantly immunomodulation therapies that have been the focus of several studies through the years. It is safe to state that supportive therapy is the only modality that has significantly strong evidence backing its efficacy in reducing mortality and improving prognosis, which have improved in the past years as general health care quality increased. In conclusion, it is imperative to say that more research is needed for new potential therapies with large study populations and more scientific rigor. Likewise, investigation towards its basic pathophysiology should also be promoted, mainly at a biomolecular level, allowing for an improved prevention of this illness." @default.
- W4290704908 created "2022-08-09" @default.
- W4290704908 creator A5007371197 @default.
- W4290704908 creator A5022710143 @default.
- W4290704908 creator A5073580442 @default.
- W4290704908 date "2022-08-08" @default.
- W4290704908 modified "2023-09-26" @default.
- W4290704908 title "Toxic Epidermal Necrolysis: A Clinical and Therapeutic Review" @default.
- W4290704908 cites W1513845385 @default.
- W4290704908 cites W1964891410 @default.
- W4290704908 cites W1989954587 @default.
- W4290704908 cites W2006223140 @default.
- W4290704908 cites W2012854350 @default.
- W4290704908 cites W2015686676 @default.
- W4290704908 cites W2023986844 @default.
- W4290704908 cites W2033011240 @default.
- W4290704908 cites W2061327035 @default.
- W4290704908 cites W2074517409 @default.
- W4290704908 cites W2074577456 @default.
- W4290704908 cites W2075184233 @default.
- W4290704908 cites W2093724404 @default.
- W4290704908 cites W2102183883 @default.
- W4290704908 cites W2109696646 @default.
- W4290704908 cites W2114864988 @default.
- W4290704908 cites W2121050460 @default.
- W4290704908 cites W2125869992 @default.
- W4290704908 cites W2132585661 @default.
- W4290704908 cites W2134537227 @default.
- W4290704908 cites W2169922209 @default.
- W4290704908 cites W2217038480 @default.
- W4290704908 cites W2804708247 @default.
- W4290704908 cites W2992464431 @default.
- W4290704908 cites W3188405615 @default.
- W4290704908 doi "https://doi.org/10.3390/ebj3030036" @default.
- W4290704908 hasPublicationYear "2022" @default.
- W4290704908 type Work @default.
- W4290704908 citedByCount "0" @default.
- W4290704908 crossrefType "journal-article" @default.
- W4290704908 hasAuthorship W4290704908A5007371197 @default.
- W4290704908 hasAuthorship W4290704908A5022710143 @default.
- W4290704908 hasAuthorship W4290704908A5073580442 @default.
- W4290704908 hasBestOaLocation W42907049081 @default.
- W4290704908 hasConcept C10162356 @default.
- W4290704908 hasConcept C142724271 @default.
- W4290704908 hasConcept C16005928 @default.
- W4290704908 hasConcept C177713679 @default.
- W4290704908 hasConcept C185592680 @default.
- W4290704908 hasConcept C190283241 @default.
- W4290704908 hasConcept C203014093 @default.
- W4290704908 hasConcept C2779134260 @default.
- W4290704908 hasConcept C2780261098 @default.
- W4290704908 hasConcept C2780664588 @default.
- W4290704908 hasConcept C31573885 @default.
- W4290704908 hasConcept C55493867 @default.
- W4290704908 hasConcept C66008609 @default.
- W4290704908 hasConcept C71924100 @default.
- W4290704908 hasConceptScore W4290704908C10162356 @default.
- W4290704908 hasConceptScore W4290704908C142724271 @default.
- W4290704908 hasConceptScore W4290704908C16005928 @default.
- W4290704908 hasConceptScore W4290704908C177713679 @default.
- W4290704908 hasConceptScore W4290704908C185592680 @default.
- W4290704908 hasConceptScore W4290704908C190283241 @default.
- W4290704908 hasConceptScore W4290704908C203014093 @default.
- W4290704908 hasConceptScore W4290704908C2779134260 @default.
- W4290704908 hasConceptScore W4290704908C2780261098 @default.
- W4290704908 hasConceptScore W4290704908C2780664588 @default.
- W4290704908 hasConceptScore W4290704908C31573885 @default.
- W4290704908 hasConceptScore W4290704908C55493867 @default.
- W4290704908 hasConceptScore W4290704908C66008609 @default.
- W4290704908 hasConceptScore W4290704908C71924100 @default.
- W4290704908 hasIssue "3" @default.
- W4290704908 hasLocation W42907049081 @default.
- W4290704908 hasOpenAccess W4290704908 @default.
- W4290704908 hasPrimaryLocation W42907049081 @default.
- W4290704908 hasRelatedWork W2026650728 @default.
- W4290704908 hasRelatedWork W2086155928 @default.
- W4290704908 hasRelatedWork W2105943909 @default.
- W4290704908 hasRelatedWork W2163959912 @default.
- W4290704908 hasRelatedWork W2262307178 @default.
- W4290704908 hasRelatedWork W2466137573 @default.
- W4290704908 hasRelatedWork W2519817947 @default.
- W4290704908 hasRelatedWork W3170712115 @default.
- W4290704908 hasRelatedWork W4290704908 @default.
- W4290704908 hasRelatedWork W2181841900 @default.
- W4290704908 hasVolume "3" @default.
- W4290704908 isParatext "false" @default.
- W4290704908 isRetracted "false" @default.
- W4290704908 workType "article" @default.