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- W4290723107 abstract "In brief Oxidative stress is recognized as an underlying driving factor of both telomere dysfunction and human subfertility/infertility. This review briefly reassesses telomere integrity as a fertility biomarker before proposing a novel, mechanistic rationale for the role of oxidative stress in the seemingly paradoxical lengthening of sperm telomeres with aging. Abstract The maintenance of redox balance in the male reproductive tract is critical to sperm health and function. Physiological levels of reactive oxygen species (ROS) promote sperm capacitation, while excess ROS exposure, or depleted antioxidant defenses, yields a state of oxidative stress which disrupts their fertilizing capacity and DNA structural integrity. The guanine moiety is the most readily oxidized of the four DNA bases and gets converted to the mutagenic lesion 8-hydroxy-deoxyguanosine (8-OHdG). Numerous studies have also confirmed oxidative stress as a driving factor behind accelerated telomere shortening and dysfunction. Although a clear consensus has not been reached, clinical studies also appear to associate telomere integrity with fertility outcomes in the assisted reproductive technology setting. Intriguingly, while sperm cellular and molecular characteristics make them more susceptible to oxidative insult than any other cell type, they are also the only cell type in which telomere lengthening accompanies aging. This article focuses on the oxidative stress response pathways to propose a mechanism for the explanation of this apparent paradox." @default.
- W4290723107 created "2022-08-09" @default.
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- W4290723107 date "2022-12-01" @default.
- W4290723107 modified "2023-10-04" @default.
- W4290723107 title "OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Sperm telomeres, oxidative stress, and infertility" @default.
- W4290723107 cites W1548915688 @default.
- W4290723107 cites W1785227132 @default.
- W4290723107 cites W1829553711 @default.
- W4290723107 cites W1892219175 @default.
- W4290723107 cites W1947923795 @default.
- W4290723107 cites W1970891016 @default.
- W4290723107 cites W1974581684 @default.
- W4290723107 cites W1977213510 @default.
- W4290723107 cites W1979391734 @default.
- W4290723107 cites W1982721804 @default.
- W4290723107 cites W1983673827 @default.
- W4290723107 cites W1987024877 @default.
- W4290723107 cites W1998461800 @default.
- W4290723107 cites W1999104687 @default.
- W4290723107 cites W1999527182 @default.
- W4290723107 cites W2003667713 @default.
- W4290723107 cites W2010882280 @default.
- W4290723107 cites W2012442261 @default.
- W4290723107 cites W2021191052 @default.
- W4290723107 cites W2027260347 @default.
- W4290723107 cites W2054592293 @default.
- W4290723107 cites W2058981467 @default.
- W4290723107 cites W2060017837 @default.
- W4290723107 cites W2068113850 @default.
- W4290723107 cites W2087010715 @default.
- W4290723107 cites W2089673771 @default.
- W4290723107 cites W2092476887 @default.
- W4290723107 cites W2093298106 @default.
- W4290723107 cites W2098312065 @default.
- W4290723107 cites W2108482850 @default.
- W4290723107 cites W2110001173 @default.
- W4290723107 cites W2121367862 @default.
- W4290723107 cites W2122740168 @default.
- W4290723107 cites W2123105653 @default.
- W4290723107 cites W2127530512 @default.
- W4290723107 cites W2128708127 @default.
- W4290723107 cites W2132920117 @default.
- W4290723107 cites W2133327420 @default.
- W4290723107 cites W2142886333 @default.
- W4290723107 cites W2147336921 @default.
- W4290723107 cites W2152588928 @default.
- W4290723107 cites W2154102346 @default.
- W4290723107 cites W2155773930 @default.
- W4290723107 cites W2170528713 @default.
- W4290723107 cites W2177539334 @default.
- W4290723107 cites W2328581228 @default.
- W4290723107 cites W2341018886 @default.
- W4290723107 cites W2463376059 @default.
- W4290723107 cites W2474137413 @default.
- W4290723107 cites W2520749639 @default.
- W4290723107 cites W2554833173 @default.
- W4290723107 cites W2554881413 @default.
- W4290723107 cites W2562067618 @default.
- W4290723107 cites W2606687868 @default.
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- W4290723107 cites W2613422438 @default.
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- W4290723107 cites W2755501245 @default.
- W4290723107 cites W2756313385 @default.
- W4290723107 cites W2789649597 @default.
- W4290723107 cites W2795121593 @default.
- W4290723107 cites W2891234967 @default.
- W4290723107 cites W2906188826 @default.
- W4290723107 cites W2908355400 @default.
- W4290723107 cites W2912422467 @default.
- W4290723107 cites W2946740283 @default.
- W4290723107 cites W2989594115 @default.
- W4290723107 cites W2999210047 @default.
- W4290723107 cites W3000267055 @default.
- W4290723107 cites W3013352992 @default.
- W4290723107 cites W3024412620 @default.
- W4290723107 cites W3037613068 @default.
- W4290723107 cites W3038743902 @default.
- W4290723107 cites W3107381448 @default.
- W4290723107 cites W3196535959 @default.
- W4290723107 cites W3199349499 @default.
- W4290723107 cites W3200698974 @default.
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- W4290723107 doi "https://doi.org/10.1530/rep-22-0189" @default.
- W4290723107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35938805" @default.
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