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- W4290730857 abstract "The present study demonstrates first time investigation on encapsulation of Aniba rosaeodora essential oil into chitosan nanoemulsion (AREO-CsNe) with the aim of improvement of its antifungal, and aflatoxin B 1 (AFB 1 ) inhibitory performance in real food system. The GC–MS analysis of AREO revealed the presence of linalool (81.46%) as a major component. The successful encapsulation of EO into CsNe was confirmed through SEM, FTIR, and XRD analysis. The in-vitro release study showed the controlled release of AREO. AREO-CsNe caused complete inhibition of Aspergillus flavus (AFLHPSi-1) growth and AFB 1 production at 0.8 and 0.6 μl/ml, respectively, which was far better than AREO (1.4 and 1.2 μl/ml, respectively). Impairment of ergosterol biosynthesis coupled with enhancement of cellular materials leakage confirmed plasma membrane as the possible antifungal target of both AREO and AREO-CsNe. Significant inhibition of methylglyoxal (AFB 1 inducer) synthesis in AFLHPSi-1 cells by AREO and AREO-CsNe confirmed their novel antiaflatoxigenic mode of action. In-silico molecular docking studies revealed effective interaction of linalool with Ver-1 and Omt-A proteins, leading to inhibition of AFB 1 biosynthesis. Further, AREO-CsNe showed enhanced antioxidant activity with IC 50 values 3.792 and 1.706 μl/ml against DPPH • and ABTS •+ radicals, respectively. In addition, AREO-CsNe caused 100% protection of stored millets ( Setaria italica seeds) from AFB 1 contamination and lipid peroxidation over a period of 1 year without compromising its sensory properties and exhibited high safety profile with LD 50 value 9538.742 μl/kg body weight. Based on enhanced performance of AREO-CsNe over AREO, it can be recommended as a novel substitute of synthetic preservative for preservation of stored millets." @default.
- W4290730857 created "2022-08-09" @default.
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- W4290730857 date "2022-08-09" @default.
- W4290730857 modified "2023-09-28" @default.
- W4290730857 title "Chitosan encompassed Aniba rosaeodora essential oil as innovative green candidate for antifungal and antiaflatoxigenic activity in millets with emphasis on cellular and its mode of action" @default.
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- W4290730857 doi "https://doi.org/10.3389/fmicb.2022.970670" @default.
- W4290730857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36016775" @default.
- W4290730857 hasPublicationYear "2022" @default.
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