Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290744491> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4290744491 abstract "Previous studies suggest that platelets are involved in fetal and adult lung development, but their role in postnatal lung development especially after premature birth is elusive. There is an urgent need to scrutinize this topic because the incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease after premature birth, remains high. We have previously shown impaired platelet biogenesis in infants and rats with BPD. In this study, we investigated the role of anti-CD41 antibody-induced platelet depletion during normal postnatal lung development and thrombopoietin (TPO)-induced platelet biogenesis in mice with experimental BPD. We demonstrate that platelet deficient mice develop a BPD-like phenotype, characterized by enlarged alveoli and vascular remodeling of the small pulmonary arteries, resulting in pulmonary arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). Vascular remodeling was potentially caused by endothelial dysfunction demonstrated by elevated von Willebrand factor (vWF) concentration in plasma and reduced vWF staining in lung tissue with platelet depletion. Furthermore, TPO-induced platelet biogenesis in mice with experimental BPD improved alveolar simplification and ameliorated vascular remodeling. These findings demonstrate that platelets are indispensable for normal postnatal lung development and attenuation of BPD, probably by maintaining endothelial function." @default.
- W4290744491 created "2022-08-09" @default.
- W4290744491 creator A5007348590 @default.
- W4290744491 creator A5009077486 @default.
- W4290744491 creator A5016818703 @default.
- W4290744491 creator A5018223832 @default.
- W4290744491 creator A5022066848 @default.
- W4290744491 creator A5024032443 @default.
- W4290744491 creator A5070272122 @default.
- W4290744491 creator A5083910939 @default.
- W4290744491 date "2022-08-09" @default.
- W4290744491 modified "2023-10-05" @default.
- W4290744491 title "Platelets are indispensable for alveolar development in neonatal mice" @default.
- W4290744491 cites W1978893674 @default.
- W4290744491 cites W1995041376 @default.
- W4290744491 cites W2018902272 @default.
- W4290744491 cites W2033042544 @default.
- W4290744491 cites W2050308681 @default.
- W4290744491 cites W2052456731 @default.
- W4290744491 cites W2087345792 @default.
- W4290744491 cites W2147892082 @default.
- W4290744491 cites W2327328530 @default.
- W4290744491 cites W2564343953 @default.
- W4290744491 cites W2600669583 @default.
- W4290744491 cites W2606582949 @default.
- W4290744491 cites W2759487020 @default.
- W4290744491 cites W2790627600 @default.
- W4290744491 cites W2805531612 @default.
- W4290744491 cites W2890367099 @default.
- W4290744491 cites W2895262792 @default.
- W4290744491 cites W2974904127 @default.
- W4290744491 cites W2977963725 @default.
- W4290744491 cites W3014259712 @default.
- W4290744491 cites W3118583265 @default.
- W4290744491 cites W3163266086 @default.
- W4290744491 cites W3163769717 @default.
- W4290744491 cites W4238182437 @default.
- W4290744491 doi "https://doi.org/10.3389/fped.2022.943054" @default.
- W4290744491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36016884" @default.
- W4290744491 hasPublicationYear "2022" @default.
- W4290744491 type Work @default.
- W4290744491 citedByCount "1" @default.
- W4290744491 countsByYear W42907444912022 @default.
- W4290744491 crossrefType "journal-article" @default.
- W4290744491 hasAuthorship W4290744491A5007348590 @default.
- W4290744491 hasAuthorship W4290744491A5009077486 @default.
- W4290744491 hasAuthorship W4290744491A5016818703 @default.
- W4290744491 hasAuthorship W4290744491A5018223832 @default.
- W4290744491 hasAuthorship W4290744491A5022066848 @default.
- W4290744491 hasAuthorship W4290744491A5024032443 @default.
- W4290744491 hasAuthorship W4290744491A5070272122 @default.
- W4290744491 hasAuthorship W4290744491A5083910939 @default.
- W4290744491 hasBestOaLocation W42907444911 @default.
- W4290744491 hasConcept C126322002 @default.
- W4290744491 hasConcept C142724271 @default.
- W4290744491 hasConcept C2777714996 @default.
- W4290744491 hasConcept C2778376644 @default.
- W4290744491 hasConcept C2778721537 @default.
- W4290744491 hasConcept C2779234561 @default.
- W4290744491 hasConcept C2779394231 @default.
- W4290744491 hasConcept C2780930700 @default.
- W4290744491 hasConcept C3018697912 @default.
- W4290744491 hasConcept C54355233 @default.
- W4290744491 hasConcept C71924100 @default.
- W4290744491 hasConcept C86803240 @default.
- W4290744491 hasConcept C89560881 @default.
- W4290744491 hasConceptScore W4290744491C126322002 @default.
- W4290744491 hasConceptScore W4290744491C142724271 @default.
- W4290744491 hasConceptScore W4290744491C2777714996 @default.
- W4290744491 hasConceptScore W4290744491C2778376644 @default.
- W4290744491 hasConceptScore W4290744491C2778721537 @default.
- W4290744491 hasConceptScore W4290744491C2779234561 @default.
- W4290744491 hasConceptScore W4290744491C2779394231 @default.
- W4290744491 hasConceptScore W4290744491C2780930700 @default.
- W4290744491 hasConceptScore W4290744491C3018697912 @default.
- W4290744491 hasConceptScore W4290744491C54355233 @default.
- W4290744491 hasConceptScore W4290744491C71924100 @default.
- W4290744491 hasConceptScore W4290744491C86803240 @default.
- W4290744491 hasConceptScore W4290744491C89560881 @default.
- W4290744491 hasFunder F4320321001 @default.
- W4290744491 hasFunder F4320337111 @default.
- W4290744491 hasLocation W42907444911 @default.
- W4290744491 hasLocation W42907444912 @default.
- W4290744491 hasLocation W42907444913 @default.
- W4290744491 hasOpenAccess W4290744491 @default.
- W4290744491 hasPrimaryLocation W42907444911 @default.
- W4290744491 hasRelatedWork W152465027 @default.
- W4290744491 hasRelatedWork W1972338693 @default.
- W4290744491 hasRelatedWork W1985812516 @default.
- W4290744491 hasRelatedWork W2054800128 @default.
- W4290744491 hasRelatedWork W2058546728 @default.
- W4290744491 hasRelatedWork W2171240439 @default.
- W4290744491 hasRelatedWork W2405499513 @default.
- W4290744491 hasRelatedWork W2915181081 @default.
- W4290744491 hasRelatedWork W2979709163 @default.
- W4290744491 hasRelatedWork W4313583181 @default.
- W4290744491 hasVolume "10" @default.
- W4290744491 isParatext "false" @default.
- W4290744491 isRetracted "false" @default.
- W4290744491 workType "article" @default.