FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290755150> ?p ?o ?g. }

• W4290755150 endingPage "401" @default.
• W4290755150 startingPage "395" @default.
• W4290755150 abstract "A defining characteristic of individuals diagnosed with alcohol use disorder (AUD) is that negative outcomes related to drinking do not lead them to reduce their alcohol use. In rodent models of AUD, this characteristic has been studied by adding the bitter tastant quinine to an ethanol solution. In this study, we extended this approach to a nonhuman primate model in which the ability of quinine to decrease the choice of a 4% ethanol solution vs. water was measured. Five adult female rhesus monkeys with 7.3 years of experience drinking ethanol were given access to a 4% ethanol solution and water for 3 h per day. When ethanol choice was stable, a single quinine concentration (0.03–5.6 g /L) was added to the ethanol solution for 1 day until a quinine concentration-effect curve was generated. After determining the quinine concentration that reduced ethanol choice by half (the quinine EC 50 ), the relative reinforcing strength of ethanol was manipulated by adding quinine or sucrose to the water alternative depending on the monkey’s baseline choice. Adding quinine to ethanol produced a concentration-dependent decrease in ethanol choice and intake. Importantly, water intake increased, indicating an effect on response allocation rather than simply a decrease in fluid consumption. Consistent with this conclusion, the addition of quinine or sucrose to the water alternative resulted in predictable increases and decreases, respectively, in ethanol choice. These studies establish a model of punishment of ethanol choice in nonhuman primates that can be used to understand the contextual, biologic and pharmacologic factors that influence sensitivity to the punishment of alcohol drinking." @default.
• W4290755150 created "2022-08-09" @default.
• W4290755150 creator A5011300248 @default.
• W4290755150 creator A5034210325 @default.
• W4290755150 creator A5042832794 @default.
• W4290755150 creator A5042978359 @default.
• W4290755150 creator A5047125828 @default.
• W4290755150 creator A5074197290 @default.
• W4290755150 creator A5087735834 @default.
• W4290755150 date "2022-08-03" @default.
• W4290755150 modified "2023-10-16" @default.
• W4290755150 title "Punishment of ethanol choice in rhesus monkeys" @default.
• W4290755150 cites W1792338879 @default.
• W4290755150 cites W1823260965 @default.
• W4290755150 cites W1895471809 @default.
• W4290755150 cites W1951461629 @default.
• W4290755150 cites W1965232467 @default.
• W4290755150 cites W1967801695 @default.
• W4290755150 cites W1973644638 @default.
• W4290755150 cites W1978400943 @default.
• W4290755150 cites W2010185204 @default.
• W4290755150 cites W2032463054 @default.
• W4290755150 cites W2058284686 @default.
• W4290755150 cites W2065662378 @default.
• W4290755150 cites W2092847788 @default.
• W4290755150 cites W2094614798 @default.
• W4290755150 cites W2112038105 @default.
• W4290755150 cites W2119546306 @default.
• W4290755150 cites W2318273724 @default.
• W4290755150 cites W2559087812 @default.
• W4290755150 cites W2726320368 @default.
• W4290755150 cites W2731547999 @default.
• W4290755150 cites W2747476598 @default.
• W4290755150 cites W2923183989 @default.
• W4290755150 cites W2936340882 @default.
• W4290755150 cites W2982552843 @default.
• W4290755150 cites W2994814414 @default.
• W4290755150 cites W3028697836 @default.
• W4290755150 cites W3122705991 @default.
• W4290755150 doi "https://doi.org/10.1097/fbp.0000000000000683" @default.
• W4290755150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35942846" @default.
• W4290755150 hasPublicationYear "2022" @default.
• W4290755150 type Work @default.
• W4290755150 citedByCount "0" @default.
• W4290755150 crossrefType "journal-article" @default.
• W4290755150 hasAuthorship W4290755150A5011300248 @default.
• W4290755150 hasAuthorship W4290755150A5034210325 @default.
• W4290755150 hasAuthorship W4290755150A5042832794 @default.
• W4290755150 hasAuthorship W4290755150A5042978359 @default.
• W4290755150 hasAuthorship W4290755150A5047125828 @default.
• W4290755150 hasAuthorship W4290755150A5074197290 @default.
• W4290755150 hasAuthorship W4290755150A5087735834 @default.
• W4290755150 hasConcept C15744967 @default.
• W4290755150 hasConcept C185592680 @default.
• W4290755150 hasConcept C203014093 @default.
• W4290755150 hasConcept C2777617192 @default.
• W4290755150 hasConcept C2778048844 @default.
• W4290755150 hasConcept C2778555786 @default.
• W4290755150 hasConcept C2778597767 @default.
• W4290755150 hasConcept C2779442783 @default.
• W4290755150 hasConcept C2780161600 @default.
• W4290755150 hasConcept C2781066024 @default.
• W4290755150 hasConcept C42219234 @default.
• W4290755150 hasConcept C55493867 @default.
• W4290755150 hasConcept C71924100 @default.
• W4290755150 hasConceptScore W4290755150C15744967 @default.
• W4290755150 hasConceptScore W4290755150C185592680 @default.
• W4290755150 hasConceptScore W4290755150C203014093 @default.
• W4290755150 hasConceptScore W4290755150C2777617192 @default.
• W4290755150 hasConceptScore W4290755150C2778048844 @default.
• W4290755150 hasConceptScore W4290755150C2778555786 @default.
• W4290755150 hasConceptScore W4290755150C2778597767 @default.
• W4290755150 hasConceptScore W4290755150C2779442783 @default.
• W4290755150 hasConceptScore W4290755150C2780161600 @default.
• W4290755150 hasConceptScore W4290755150C2781066024 @default.
• W4290755150 hasConceptScore W4290755150C42219234 @default.
• W4290755150 hasConceptScore W4290755150C55493867 @default.
• W4290755150 hasConceptScore W4290755150C71924100 @default.
• W4290755150 hasIssue "6" @default.
• W4290755150 hasLocation W42907551501 @default.
• W4290755150 hasLocation W42907551502 @default.
• W4290755150 hasOpenAccess W4290755150 @default.
• W4290755150 hasPrimaryLocation W42907551501 @default.
• W4290755150 hasRelatedWork W1758259063 @default.
• W4290755150 hasRelatedWork W1976012957 @default.
• W4290755150 hasRelatedWork W2000490990 @default.
• W4290755150 hasRelatedWork W2012760046 @default.
• W4290755150 hasRelatedWork W2089760387 @default.
• W4290755150 hasRelatedWork W2132892403 @default.
• W4290755150 hasRelatedWork W2144456014 @default.
• W4290755150 hasRelatedWork W2166661401 @default.
• W4290755150 hasRelatedWork W2617806010 @default.
• W4290755150 hasRelatedWork W4290755150 @default.
• W4290755150 hasVolume "33" @default.
• W4290755150 isParatext "false" @default.
• W4290755150 isRetracted "false" @default.
• W4290755150 workType "article" @default.