Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290767706> ?p ?o ?g. }
- W4290767706 endingPage "111154" @default.
- W4290767706 startingPage "111154" @default.
- W4290767706 abstract "MicroRNA (miRNA) abundance is tightly controlled by regulation of biogenesis and decay. Here, we show that the mir-35 miRNA family undergoes selective decay at the transition from embryonic to larval development in C. elegans. The seed sequence of the miRNA is necessary and largely sufficient for this regulation. Sequences outside the seed (3′ end) regulate mir-35 abundance in the embryo but are not necessary for sharp decay at the transition to larval development. Enzymatic modifications of the miRNA 3′ end are neither prevalent nor correlated with changes in decay, suggesting that miRNA 3′ end display is not a core feature of this mechanism and further supporting a seed-driven decay model. Our findings demonstrate that seed-sequence-specific decay can selectively and coherently regulate all redundant members of a miRNA seed family, a class of mechanism that has great biological and therapeutic potential for dynamic regulation of a miRNA family’s target repertoire." @default.
- W4290767706 created "2022-08-09" @default.
- W4290767706 creator A5001655208 @default.
- W4290767706 creator A5019494660 @default.
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- W4290767706 creator A5057865384 @default.
- W4290767706 creator A5063877587 @default.
- W4290767706 creator A5083143789 @default.
- W4290767706 date "2022-08-01" @default.
- W4290767706 modified "2023-10-01" @default.
- W4290767706 title "The developmentally timed decay of an essential microRNA family is seed-sequence dependent" @default.
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