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• W4290804364 endingPage "517" @default.
• W4290804364 startingPage "443" @default.
• W4290804364 abstract "Parasitic infections are a big problem in tropical and subtropical regions of the world. Malaria is one of the deadliest parasitic diseases. the synthetic drugs used to treat parasitic infections have now become resistant to parasitic strains. Antiparasitic drugs act by either of the cellular mechanisms of action, i.e., (i) inhibition of DNA, RNA. (ii) cytoskeleton protein inhibition (iii)) biomembrane inhibition. Malaria is a deadly parasitic infection caused by Plasmodium falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi . Traditional medicinal herbs are widely used for the successful treatment of parasitic infections. In the present chapter, in-vitro studies of 73 plants were reported for their efficacy in 11 different types of Pl. falciferum , namely 3D7, Dd2, CAM06, Ghana, FCG-3, FCB, IPC4912, Indo, K1, W2 and clinically isolated Plasmodium . The in-vitro bioassay was estimated using the schizont maturation inhibition assay, pLDH assay, parasite growth inhibition, 3H-hypoxanthine uptake inhibition assay, β-hematin inhibition, histidine-rich protein II antibody estimation and the SYBR green I-based fluorescence assay. The 15 plants were documented as very potent antiplasmodial plants with an IC50 < 5 μg/ml. The medicinal plants, i.e. Alstonia scholaris leaves; Brucea sumatrana seeds; Croton mubango stem bark; Epinetrum villosum root; Eremostachys macrophylla rhizome; Garcinia atroviridis leaves; Garcinia mangostana leaves; Momordica charantia fruit; Nauclea pobeguinii Stem bark; Picrolemma sprucei leaves; Picrolemma huberi cortex, petiole and rachis; Quassia africana root bark; Strychnos icaja root bark; Tinospora crispa L. leaves; Triclisia gilletii leaves, stem bark and root bark found to possess potent (IC50<5 μg/ml) antimalarial activity. Among the afore mentioned plants, B. sumatrana Roxb. seed (IC50<0.25 g/ml) Triclisia gilletii root bark (0.02 μg/ml) was reported to potent in-vitro activity. A total of 40 medicinal plants were compiled for in-vivo antimalarial activity. The total 10 plants, i.e., Cucumis metuliferus leaves, Coccinia barteri leaves, Euphorbia abyssinica root, Glycine max seed, Lippia kituiensis leaves, Nigella sativa seed, Plectranthus barbatus root bark, Pseudocedrela kotschyi leaves, Strychnos mitis leaves, and Zanthoxylum chalybeum root bark, showed more than 70% parasithemia suppression. Among them, six plants, namely Cucumis metuliferus leaves, Euphorbia abyssinica root, Lippia kituiensis leaves, Strychnos mitis leaves, Pseudocedrela kotschyi leaves, were documented with 90% parasithemia suppression and considered potent antimalarial plants." @default.
• W4290804364 created "2022-08-12" @default.
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• W4290804364 date "2022-08-01" @default.
• W4290804364 modified "2023-10-16" @default.
• W4290804364 title "Herbs Used in Parasitic Infection—Malaria" @default.
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• W4290804364 doi "https://doi.org/10.1002/9781119818779.ch16" @default.
• W4290804364 hasPublicationYear "2022" @default.
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