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• W4290804426 startingPage "74" @default.
• W4290804426 abstract "Microglia are tissue-resident macrophages responsible for the surveillance, neuronal support, and immune defense of the brain parenchyma. Recently, the role played by microglia in the formation and function of neuronal circuits has garnered substantial attention. During development, microglia have been shown to engulf neuronal precursors and participate in pruning mechanisms while, in the mature brain, they influence synaptic signaling, provide trophic support and shape synaptic plasticity. Recently, studies have unveiled different microglial characteristics associated with specific brain regions. This emerging view suggests that the maturation and function of distinct neuronal circuits may be potentially associated with the molecular identity microglia adopts across the brain. Here, we review and summarize the known role of these cells in the thalamus, hippocampus, cortex, and cerebellum. We focus on in vivo studies to highlight the characteristics of microglia that may be important in the remodeling of these neuronal circuits and in relation to neurodevelopmental and neuropsychiatric disorders." @default.
• W4290804426 created "2022-08-12" @default.
• W4290804426 creator A5001995198 @default.
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• W4290804426 creator A5058984825 @default.
• W4290804426 creator A5067232356 @default.
• W4290804426 creator A5069397403 @default.
• W4290804426 date "2022-09-05" @default.
• W4290804426 modified "2023-10-06" @default.
• W4290804426 title "Microglia‐dependent remodeling of neuronal circuits" @default.
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