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- W4290806339 endingPage "670" @default.
- W4290806339 startingPage "649" @default.
- W4290806339 abstract "Anaphylactoid reactions to RCM occur with significant frequency in patients who have experienced a previous reaction and who have to be given RCM again. The mechanism of production of these reactions has not been clearly elucidated but probably involves the release of histamine and other mediators from mast cells and perhaps basophils. Fortunately, previous reactors who would, if left untreated, develop a repeat reaction with an incidence ranging between 16% and 44% can be pretreated to reduce the incidence of recurrence. With a full pretreatment regimen, the recurrence rate may be as low as 1%. This regimen consists of diphenhydramine, 50 mg intramuscularly, 1 hour before; prednisone, 50 mg orally, 13, 7, and 1 hour before; and ephedrine, 25 mg orally, 1 hour before the procedure. In addition, a lower osmolar agent should be used. An H2 antagonist can be added to this protocol at the discretion of the physician, but there is controversy regarding its use. This pretreatment regimen should be used regardless of the route of administration of RCM. If the previous reaction was not anaphylactoid in nature and consisted of the adult respiratory distress syndrome, the pretreatment regimen may not be effective." @default.
- W4290806339 created "2022-08-12" @default.
- W4290806339 creator A5000303988 @default.
- W4290806339 date "1992-08-01" @default.
- W4290806339 modified "2023-10-09" @default.
- W4290806339 title "ANAPHYLACTOID REACTIONS TO RADIOCONTRAST MATERIAL" @default.
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