Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290830499> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4290830499 endingPage "e2.103" @default.
- W4290830499 startingPage "e2.103" @default.
- W4290830499 abstract "Aim To evaluate changes in retinal thickness (µm), including the retinal nerve fibre layer (RNFL) and combined ganglion cell and inner plexiform layers (GCIPL), in patients receiving siponimod or placebo. Methods Changes in optical coherence tomography (OCT) measurements from screening to M12 and M24 were compared between the two treatment groups using mixed models for repeated measures adjusted for treatment, age, sex and respective baseline OCT variables. Results The OCT sub-study included 159 patients (siponimod, n=104; placebo, n=55). RNFL thickness at M12 numerically favoured siponimod (0.39 vs −0.99; p=0.099) but not at M24 (−0.05 vs. 0.48; p=0.642). However, fewer assessments were available for RNFL at M24 than M12. The between-group difference in GCIPL thinning was 0.21 (−2.55 vs −2.76; p=0.875) at M12 and 3.82 (−0.47 vs −4.29; p=0.01) at M24. Siponimod reduced retinal thinning vs placebo at M12 (change from baseline: 0.66 vs −1.86; p=0.006) and M24 (−0.05 vs −2.3; p=0.033). Changes of retinal thickness and GCIPL at the subfield areas also favoured siponimod over placebo. Conclusions These results support the sensitivity of OCT as a measure of tissue damage in progressive MS and are in line with previously reported beneficial effects of siponimod on other neurodegeneration related outcomes. Funding: Novartis Pharma AG, Basel, Switzerland." @default.
- W4290830499 created "2022-08-12" @default.
- W4290830499 creator A5012126889 @default.
- W4290830499 creator A5015754502 @default.
- W4290830499 creator A5020903163 @default.
- W4290830499 creator A5025593542 @default.
- W4290830499 creator A5027672600 @default.
- W4290830499 creator A5027932985 @default.
- W4290830499 creator A5029734617 @default.
- W4290830499 creator A5035730229 @default.
- W4290830499 creator A5062220148 @default.
- W4290830499 creator A5077310868 @default.
- W4290830499 date "2022-08-12" @default.
- W4290830499 modified "2023-10-16" @default.
- W4290830499 title "147 Siponimod preserves retinal thickness: findings from the EXPAND OCT substudy" @default.
- W4290830499 doi "https://doi.org/10.1136/jnnp-2022-abn2.191" @default.
- W4290830499 hasPublicationYear "2022" @default.
- W4290830499 type Work @default.
- W4290830499 citedByCount "0" @default.
- W4290830499 crossrefType "journal-article" @default.
- W4290830499 hasAuthorship W4290830499A5012126889 @default.
- W4290830499 hasAuthorship W4290830499A5015754502 @default.
- W4290830499 hasAuthorship W4290830499A5020903163 @default.
- W4290830499 hasAuthorship W4290830499A5025593542 @default.
- W4290830499 hasAuthorship W4290830499A5027672600 @default.
- W4290830499 hasAuthorship W4290830499A5027932985 @default.
- W4290830499 hasAuthorship W4290830499A5029734617 @default.
- W4290830499 hasAuthorship W4290830499A5035730229 @default.
- W4290830499 hasAuthorship W4290830499A5062220148 @default.
- W4290830499 hasAuthorship W4290830499A5077310868 @default.
- W4290830499 hasConcept C118487528 @default.
- W4290830499 hasConcept C126322002 @default.
- W4290830499 hasConcept C142724271 @default.
- W4290830499 hasConcept C204787440 @default.
- W4290830499 hasConcept C27081682 @default.
- W4290830499 hasConcept C2778818243 @default.
- W4290830499 hasConcept C2780592520 @default.
- W4290830499 hasConcept C2780827179 @default.
- W4290830499 hasConcept C2781099447 @default.
- W4290830499 hasConcept C2910804505 @default.
- W4290830499 hasConcept C71924100 @default.
- W4290830499 hasConceptScore W4290830499C118487528 @default.
- W4290830499 hasConceptScore W4290830499C126322002 @default.
- W4290830499 hasConceptScore W4290830499C142724271 @default.
- W4290830499 hasConceptScore W4290830499C204787440 @default.
- W4290830499 hasConceptScore W4290830499C27081682 @default.
- W4290830499 hasConceptScore W4290830499C2778818243 @default.
- W4290830499 hasConceptScore W4290830499C2780592520 @default.
- W4290830499 hasConceptScore W4290830499C2780827179 @default.
- W4290830499 hasConceptScore W4290830499C2781099447 @default.
- W4290830499 hasConceptScore W4290830499C2910804505 @default.
- W4290830499 hasConceptScore W4290830499C71924100 @default.
- W4290830499 hasIssue "9" @default.
- W4290830499 hasLocation W42908304991 @default.
- W4290830499 hasOpenAccess W4290830499 @default.
- W4290830499 hasPrimaryLocation W42908304991 @default.
- W4290830499 hasRelatedWork W1989642498 @default.
- W4290830499 hasRelatedWork W2009534627 @default.
- W4290830499 hasRelatedWork W2085051551 @default.
- W4290830499 hasRelatedWork W2224441038 @default.
- W4290830499 hasRelatedWork W2266946628 @default.
- W4290830499 hasRelatedWork W2678151365 @default.
- W4290830499 hasRelatedWork W2931337326 @default.
- W4290830499 hasRelatedWork W3005665173 @default.
- W4290830499 hasRelatedWork W3012453058 @default.
- W4290830499 hasRelatedWork W3136538122 @default.
- W4290830499 hasVolume "93" @default.
- W4290830499 isParatext "false" @default.
- W4290830499 isRetracted "false" @default.
- W4290830499 workType "article" @default.