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• W4290839566 endingPage "e29536" @default.
• W4290839566 startingPage "e29536" @default.
• W4290839566 abstract "Immune checkpoint inhibitors (ICIs) showed promising therapeutic efficacy on melanoma. Neutrophil-to-lymphocyte ratio (NLR) and serum lactate dehydrogenase (LDH) showed predictive values on prognosis of various tumors, but not on melanoma yet. This meta-analysis was conducted to investigate the prognostic role of NLR and LDH levels in melanoma treated with ICIs.A search was conducted for all reports published till March 2020 in PubMed, Web of Science, Cochrane Library, EMBASE, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform (ICTRP). Studies were included if they investigated the association between pretreatment NLR/LDH and prognosis in melanoma patients treated with ICIs. Subgroup analysis, publication bias, and meta-regression were conducted to investigate heterogeneity.A total of 6817 melanoma patients were included. Overall, high pretreatment NLR and LDH were associated with poor overall survival (OS) (P < .001) and PFS (P < .001). Subgroup analyses revealed that elevated NLR and LDH levels were associated with poor OS and PFS in patients treated with anti-CTLA-4 or anti-PD-1/PD-L1 alone. NLR level was superior in predicting OS if compared with LDH level in patients treated with anti-PD-1/PD-L1 + anti-CTLA-4. In subgroup analysis stratified by cutoff value, high NLR level was associated with poor OS and PFS regardless of cutoff value, but LDH works when cutoff value = upper normal limit (UNL). The predictive value of NLR and LDH levels on OS and PFS was partially compromised in the Asian populations, compared with the Western countries.Blood NLR and LDH levels showed great potential to be used as early prognostic biomarkers in melanoma patients treated with ICIs." @default.
• W4290839566 created "2022-08-12" @default.
• W4290839566 creator A5000432967 @default.
• W4290839566 creator A5026315981 @default.
• W4290839566 creator A5066396136 @default.
• W4290839566 creator A5067104727 @default.
• W4290839566 date "2022-08-12" @default.
• W4290839566 modified "2023-10-10" @default.
• W4290839566 title "Prognostic value of neutrophil-lymphocyte ratio and lactate dehydrogenase in melanoma patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis" @default.
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• W4290839566 doi "https://doi.org/10.1097/md.0000000000029536" @default.
• W4290839566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35960066" @default.
• W4290839566 hasPublicationYear "2022" @default.
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