FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290839914> ?p ?o ?g. }

• W4290839914 abstract "The treatment landscape of advanced non-small cell lung cancer (NSCLC) has changed dramatically since the emergence of immune checkpoint inhibitors (ICIs). Although some patients achieve long survival with relatively mild toxicities, not all patients experience such benefits from ICI treatment. There are several ways to use ICIs in NSCLC patients, including monotherapy, combination immunotherapy, and combination chemoimmunotherapy. Decision-making in the selection of an ICI treatment regimen for NSCLC is complicated partly because of the absence of head-to-head prospective comparisons. Programmed death-ligand 1 (PD-L1) expression is currently considered a standard biomarker for predicting the efficacy of ICIs, although some limitations exist. In addition to the PD-L1 tumor proportion score, many other clinical factors should also be considered to determine the optimal treatment strategy for each patient, including age, performance status, histological subtypes, comorbidities, status of oncogenic driver mutation, and metastatic sites. Nevertheless, evidence of the efficacy and safety of ICIs with some specific conditions of these factors is insufficient. Indeed, patients with poor performance status, oncogenic driver mutations, or interstitial lung disease have frequently been set as ineligible in randomized clinical trials of NSCLC. ICI use in these patients is controversial and remains to be discussed. It is important to select patients for whom ICIs can benefit the most from these populations. In this article, we review previous reports of clinical trials or experience in using ICIs in NSCLC, focusing on several clinical factors that are associated with treatment outcomes, and then discuss the optimal ICI treatment strategies for NSCLC." @default.
• W4290839914 created "2022-08-12" @default.
• W4290839914 creator A5053721730 @default.
• W4290839914 creator A5086058658 @default.
• W4290839914 date "2022-08-12" @default.
• W4290839914 modified "2023-10-04" @default.
• W4290839914 title "Choosing the optimal immunotherapeutic strategies for non-small cell lung cancer based on clinical factors" @default.
• W4290839914 cites W1428284454 @default.
• W4290839914 cites W1603230122 @default.
• W4290839914 cites W1838939739 @default.
• W4290839914 cites W1965216315 @default.
• W4290839914 cites W1966561569 @default.
• W4290839914 cites W1982488143 @default.
• W4290839914 cites W1988933894 @default.
• W4290839914 cites W2003601931 @default.
• W4290839914 cites W2004426145 @default.
• W4290839914 cites W2004451956 @default.
• W4290839914 cites W2009519656 @default.
• W4290839914 cites W2012063336 @default.
• W4290839914 cites W2012295597 @default.
• W4290839914 cites W2037139573 @default.
• W4290839914 cites W2045314288 @default.
• W4290839914 cites W2062783581 @default.
• W4290839914 cites W2067431747 @default.
• W4290839914 cites W2067969350 @default.
• W4290839914 cites W2074049645 @default.
• W4290839914 cites W2088270805 @default.
• W4290839914 cites W2096198395 @default.
• W4290839914 cites W2099505374 @default.
• W4290839914 cites W2099530756 @default.
• W4290839914 cites W2104347254 @default.
• W4290839914 cites W2111662961 @default.
• W4290839914 cites W2116607009 @default.
• W4290839914 cites W2125665528 @default.
• W4290839914 cites W2129360604 @default.
• W4290839914 cites W2130930958 @default.
• W4290839914 cites W2132157071 @default.
• W4290839914 cites W2133869810 @default.
• W4290839914 cites W2156353875 @default.
• W4290839914 cites W2160337040 @default.
• W4290839914 cites W2160966526 @default.
• W4290839914 cites W2160982674 @default.
• W4290839914 cites W2163351155 @default.
• W4290839914 cites W2166084034 @default.
• W4290839914 cites W2171139285 @default.
• W4290839914 cites W2173908789 @default.
• W4290839914 cites W2198093519 @default.
• W4290839914 cites W2293531514 @default.
• W4290839914 cites W2400514548 @default.
• W4290839914 cites W2464620827 @default.
• W4290839914 cites W2497746146 @default.
• W4290839914 cites W2508205285 @default.
• W4290839914 cites W2522337762 @default.
• W4290839914 cites W2527905628 @default.
• W4290839914 cites W2533419167 @default.
• W4290839914 cites W2538232731 @default.
• W4290839914 cites W2559804019 @default.
• W4290839914 cites W2560367415 @default.
• W4290839914 cites W2560704457 @default.
• W4290839914 cites W2567564314 @default.
• W4290839914 cites W2572174216 @default.
• W4290839914 cites W2581996620 @default.
• W4290839914 cites W2587048937 @default.
• W4290839914 cites W2588916311 @default.
• W4290839914 cites W2601621622 @default.
• W4290839914 cites W2607272476 @default.
• W4290839914 cites W2635951006 @default.
• W4290839914 cites W2745126191 @default.
• W4290839914 cites W2753432434 @default.
• W4290839914 cites W2753529762 @default.
• W4290839914 cites W2759456830 @default.
• W4290839914 cites W2760661635 @default.
• W4290839914 cites W2762777471 @default.
• W4290839914 cites W276343765 @default.
• W4290839914 cites W2768062736 @default.
• W4290839914 cites W2769570103 @default.
• W4290839914 cites W2770647936 @default.
• W4290839914 cites W2775356055 @default.
• W4290839914 cites W2777461561 @default.
• W4290839914 cites W2786987313 @default.
• W4290839914 cites W2790743957 @default.
• W4290839914 cites W2791290180 @default.
• W4290839914 cites W2791886669 @default.
• W4290839914 cites W2792937256 @default.
• W4290839914 cites W2794419219 @default.
• W4290839914 cites W2794627893 @default.
• W4290839914 cites W2796582438 @default.
• W4290839914 cites W2796929908 @default.
• W4290839914 cites W2803647087 @default.
• W4290839914 cites W2804344673 @default.
• W4290839914 cites W2804812017 @default.
• W4290839914 cites W2805354595 @default.
• W4290839914 cites W2805592007 @default.
• W4290839914 cites W2808218863 @default.
• W4290839914 cites W2885658600 @default.
• W4290839914 cites W2888297491 @default.
• W4290839914 cites W2889444510 @default.
• W4290839914 cites W2892640821 @default.
• W4290839914 cites W2895543265 @default.
• W4290839914 cites W2899413762 @default.

• next