FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290861674> ?p ?o ?g. }

• W4290861674 endingPage "416" @default.
• W4290861674 startingPage "403" @default.
• W4290861674 abstract "Enterobacterales have developed a specialized outer membrane polysaccharide (enterobacterial common antigen [ECA]). ECA biosynthesis begins on the cytoplasmic side of the inner membrane (IM) where glycosyltransferases sequentially add sugar moieties to form a complete repeat unit which is then translocated across the IM by WzxE before being polymerized into short linear chains by WzyE/WzzE. Research into WecG, the enzyme responsible for generating ECA lipid-II, has not progressed beyond Barr et al. (1988) who described WecG as a membrane protein. Here we revise our understanding of WecG and re-characterize it as a peripherally associated membrane protein. Through the use of Western immunoblotting we show that WecG in Shigella flexneri is maintained to the IM via its three C-terminal helices and further identify key residues in helix II which are critical for this interaction which has allowed us to identify WecG as a GT-E glycosyltransferase. We investigate the possibility of protein complexes and ultimately show that ECA lipid-I maintains WecG to the membrane which is crucial for its function. This research is the first since Barr et al. (1988) to investigate the biochemistry of WecG and reveals possible novel drug targets to inhibit WecG and thus ECA function and cell viability." @default.
• W4290861674 created "2022-08-12" @default.
• W4290861674 creator A5023033615 @default.
• W4290861674 creator A5056350821 @default.
• W4290861674 creator A5081233934 @default.
• W4290861674 date "2022-08-25" @default.
• W4290861674 modified "2023-09-27" @default.
• W4290861674 title "Subcellular localization of the enterobacterial common antigen <scp>GT‐E‐</scp>like glycosyltransferase, <scp>WecG</scp>" @default.
• W4290861674 cites W1481859301 @default.
• W4290861674 cites W1496556712 @default.
• W4290861674 cites W1916210473 @default.
• W4290861674 cites W193673460 @default.
• W4290861674 cites W1981264193 @default.
• W4290861674 cites W1987134040 @default.
• W4290861674 cites W1994095141 @default.
• W4290861674 cites W2003952807 @default.
• W4290861674 cites W2029476353 @default.
• W4290861674 cites W2033567679 @default.
• W4290861674 cites W2054941036 @default.
• W4290861674 cites W2055177969 @default.
• W4290861674 cites W2077417665 @default.
• W4290861674 cites W2093569327 @default.
• W4290861674 cites W2101848104 @default.
• W4290861674 cites W2111967267 @default.
• W4290861674 cites W2115993183 @default.
• W4290861674 cites W2116137883 @default.
• W4290861674 cites W2120772351 @default.
• W4290861674 cites W2121085961 @default.
• W4290861674 cites W2126897199 @default.
• W4290861674 cites W2127470269 @default.
• W4290861674 cites W2139136118 @default.
• W4290861674 cites W2140838225 @default.
• W4290861674 cites W2143726587 @default.
• W4290861674 cites W2151436324 @default.
• W4290861674 cites W2152770371 @default.
• W4290861674 cites W2157995916 @default.
• W4290861674 cites W2174282801 @default.
• W4290861674 cites W2427031900 @default.
• W4290861674 cites W2584604027 @default.
• W4290861674 cites W2886911162 @default.
• W4290861674 cites W2887405283 @default.
• W4290861674 cites W2952073529 @default.
• W4290861674 cites W2981414071 @default.
• W4290861674 cites W3080518457 @default.
• W4290861674 cites W3081291240 @default.
• W4290861674 cites W3124206312 @default.
• W4290861674 cites W3138062116 @default.
• W4290861674 cites W3139337351 @default.
• W4290861674 cites W3177828909 @default.
• W4290861674 cites W4221005938 @default.
• W4290861674 cites W4224950059 @default.
• W4290861674 cites W4290861674 @default.
• W4290861674 cites W69410109 @default.
• W4290861674 doi "https://doi.org/10.1111/mmi.14973" @default.
• W4290861674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36006410" @default.
• W4290861674 hasPublicationYear "2022" @default.
• W4290861674 type Work @default.
• W4290861674 citedByCount "1" @default.
• W4290861674 countsByYear W42908616742022 @default.
• W4290861674 crossrefType "journal-article" @default.
• W4290861674 hasAuthorship W4290861674A5023033615 @default.
• W4290861674 hasAuthorship W4290861674A5056350821 @default.
• W4290861674 hasAuthorship W4290861674A5081233934 @default.
• W4290861674 hasBestOaLocation W42908616742 @default.
• W4290861674 hasConcept C104317684 @default.
• W4290861674 hasConcept C14036430 @default.
• W4290861674 hasConcept C144647389 @default.
• W4290861674 hasConcept C146587185 @default.
• W4290861674 hasConcept C161019410 @default.
• W4290861674 hasConcept C181199279 @default.
• W4290861674 hasConcept C190062978 @default.
• W4290861674 hasConcept C2776879804 @default.
• W4290861674 hasConcept C2776986154 @default.
• W4290861674 hasConcept C2781217973 @default.
• W4290861674 hasConcept C41625074 @default.
• W4290861674 hasConcept C547475151 @default.
• W4290861674 hasConcept C55493867 @default.
• W4290861674 hasConcept C86803240 @default.
• W4290861674 hasConcept C95444343 @default.
• W4290861674 hasConceptScore W4290861674C104317684 @default.
• W4290861674 hasConceptScore W4290861674C14036430 @default.
• W4290861674 hasConceptScore W4290861674C144647389 @default.
• W4290861674 hasConceptScore W4290861674C146587185 @default.
• W4290861674 hasConceptScore W4290861674C161019410 @default.
• W4290861674 hasConceptScore W4290861674C181199279 @default.
• W4290861674 hasConceptScore W4290861674C190062978 @default.
• W4290861674 hasConceptScore W4290861674C2776879804 @default.
• W4290861674 hasConceptScore W4290861674C2776986154 @default.
• W4290861674 hasConceptScore W4290861674C2781217973 @default.
• W4290861674 hasConceptScore W4290861674C41625074 @default.
• W4290861674 hasConceptScore W4290861674C547475151 @default.
• W4290861674 hasConceptScore W4290861674C55493867 @default.
• W4290861674 hasConceptScore W4290861674C86803240 @default.
• W4290861674 hasConceptScore W4290861674C95444343 @default.
• W4290861674 hasFunder F4320334704 @default.
• W4290861674 hasIssue "4" @default.
• W4290861674 hasLocation W42908616741 @default.
• W4290861674 hasLocation W42908616742 @default.

• next