Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290888764> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4290888764 abstract "Abstract Background Interleukin-2 was originally thought to be a proinflammatory factor, but recent studies have revealed that low-dose interleukin-2 might have an anti-inflammatory property. The aim of the study was to reveal whether the cytokine inhibited neuroinflammation in a high-fat diet mouse model and to further reveal the mechanism involved. Methods Mice were treated with a single administration of an AAV-interleukin-2 or AAV-LUC vector. Then, the mice were fed a normal or high-fat diet for 12 weeks, followed by a 4-week intervention period. During the intervention period, some of the mice were treated with CREB inhibitor 666 − 15. Then, cognitive function and depression-like behavior were assessed using the Morris water maze, sucrose preference test and tail suspension test. The expression of p-CREB, several microglial polarizations and inflammasome markers were measured using western blotting. The rate of pyroptosis and expansion and activation of Tregs were assessed using flow cytometry. Results A high-fat diet caused cognitive impairment and depression-like behavior in the mice. Meanwhile, the high-fat diet also inhibited the expansion and activation of Tregs, promoted microglial M1 polarization, activated the NLRP3 inflammasome and pyroptosis in the hippocampus, and eventually induced significant neuroinflammation in the hippocampus. Low-dose IL-2 using an AAV vector reversed these cognitive, behavioral and pathophysiological abnormalities. However, 666 − 15 treatment weakened the protective effect of IL-2 and aggravated cognitive impairment, neuroinflammation and all other abnormalities in the mice. Conclusion Low-dose interleukin-2 alleviated neuroinflammation and cognitive impairment by activating CREB signaling in high-fat diet mice." @default.
- W4290888764 created "2022-08-12" @default.
- W4290888764 creator A5032351338 @default.
- W4290888764 creator A5032769690 @default.
- W4290888764 creator A5039767314 @default.
- W4290888764 creator A5090539047 @default.
- W4290888764 date "2022-08-12" @default.
- W4290888764 modified "2023-09-26" @default.
- W4290888764 title "Low-dose interleukin-2 alleviates neuroinflammation and improves cognitive impairment in high-fat diet mice" @default.
- W4290888764 cites W1620767500 @default.
- W4290888764 cites W1636793459 @default.
- W4290888764 cites W1964118321 @default.
- W4290888764 cites W1970246068 @default.
- W4290888764 cites W1990430301 @default.
- W4290888764 cites W2015959034 @default.
- W4290888764 cites W2021654494 @default.
- W4290888764 cites W2058052370 @default.
- W4290888764 cites W2059444685 @default.
- W4290888764 cites W2081424375 @default.
- W4290888764 cites W2090701428 @default.
- W4290888764 cites W2121580217 @default.
- W4290888764 cites W2153142861 @default.
- W4290888764 cites W2200279205 @default.
- W4290888764 cites W2257167523 @default.
- W4290888764 cites W2513786331 @default.
- W4290888764 cites W2561221875 @default.
- W4290888764 cites W2596301176 @default.
- W4290888764 cites W2753954045 @default.
- W4290888764 cites W2800051091 @default.
- W4290888764 cites W2888928471 @default.
- W4290888764 cites W2904991239 @default.
- W4290888764 cites W2944565277 @default.
- W4290888764 cites W2980213015 @default.
- W4290888764 cites W2996406638 @default.
- W4290888764 cites W3087789132 @default.
- W4290888764 cites W3107395714 @default.
- W4290888764 cites W3201545960 @default.
- W4290888764 doi "https://doi.org/10.21203/rs.3.rs-1932936/v1" @default.
- W4290888764 hasPublicationYear "2022" @default.
- W4290888764 type Work @default.
- W4290888764 citedByCount "0" @default.
- W4290888764 crossrefType "posted-content" @default.
- W4290888764 hasAuthorship W4290888764A5032351338 @default.
- W4290888764 hasAuthorship W4290888764A5032769690 @default.
- W4290888764 hasAuthorship W4290888764A5039767314 @default.
- W4290888764 hasAuthorship W4290888764A5090539047 @default.
- W4290888764 hasBestOaLocation W42908887641 @default.
- W4290888764 hasConcept C126322002 @default.
- W4290888764 hasConcept C134018914 @default.
- W4290888764 hasConcept C164027704 @default.
- W4290888764 hasConcept C17172800 @default.
- W4290888764 hasConcept C203014093 @default.
- W4290888764 hasConcept C2776914184 @default.
- W4290888764 hasConcept C2777209026 @default.
- W4290888764 hasConcept C2778690821 @default.
- W4290888764 hasConcept C2781161787 @default.
- W4290888764 hasConcept C44752575 @default.
- W4290888764 hasConcept C71924100 @default.
- W4290888764 hasConcept C74172505 @default.
- W4290888764 hasConcept C87753298 @default.
- W4290888764 hasConcept C98274493 @default.
- W4290888764 hasConceptScore W4290888764C126322002 @default.
- W4290888764 hasConceptScore W4290888764C134018914 @default.
- W4290888764 hasConceptScore W4290888764C164027704 @default.
- W4290888764 hasConceptScore W4290888764C17172800 @default.
- W4290888764 hasConceptScore W4290888764C203014093 @default.
- W4290888764 hasConceptScore W4290888764C2776914184 @default.
- W4290888764 hasConceptScore W4290888764C2777209026 @default.
- W4290888764 hasConceptScore W4290888764C2778690821 @default.
- W4290888764 hasConceptScore W4290888764C2781161787 @default.
- W4290888764 hasConceptScore W4290888764C44752575 @default.
- W4290888764 hasConceptScore W4290888764C71924100 @default.
- W4290888764 hasConceptScore W4290888764C74172505 @default.
- W4290888764 hasConceptScore W4290888764C87753298 @default.
- W4290888764 hasConceptScore W4290888764C98274493 @default.
- W4290888764 hasLocation W42908887641 @default.
- W4290888764 hasOpenAccess W4290888764 @default.
- W4290888764 hasPrimaryLocation W42908887641 @default.
- W4290888764 hasRelatedWork W2079933648 @default.
- W4290888764 hasRelatedWork W2144241574 @default.
- W4290888764 hasRelatedWork W3003308701 @default.
- W4290888764 hasRelatedWork W3031630899 @default.
- W4290888764 hasRelatedWork W3121952957 @default.
- W4290888764 hasRelatedWork W3178105799 @default.
- W4290888764 hasRelatedWork W4221096333 @default.
- W4290888764 hasRelatedWork W4284882436 @default.
- W4290888764 hasRelatedWork W4367185504 @default.
- W4290888764 hasRelatedWork W4376275148 @default.
- W4290888764 isParatext "false" @default.
- W4290888764 isRetracted "false" @default.
- W4290888764 workType "article" @default.