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- W4290927211 abstract "The preconceptual, intrauterine, and early life environments can have a profound and long-lasting impact on the developmental trajectories and health outcomes of the offspring. Given the relatively low success rates of assisted reproductive technologies (ART; ∼25%), additives and adjuvants, such as glucocorticoids, are used to improve the success rate. Considering the dynamic developmental events that occur during this window, these exposures may alter blastocyst formation at a molecular level, and as such, affect not only the viability of the embryo and the ability of the blastocyst to implant, but also the developmental trajectory of the first three cell lineages, ultimately influencing the physiology of the embryo. In this study, we present a comprehensive single-cell transcriptome, methylome, and small RNA atlas in the day 7 human embryo. We show that, despite no change in morphology and developmental features, preimplantation glucocorticoid exposure reprograms the molecular profile of the TE lineage, and these changes are associated with an altered metabolic and inflammatory response. Our data also suggest that glucocorticoids can precociously mature the TE sublineages, supported by the presence of extravillous trophoblast markers in the polar sublineage and presence of X Chromosome dosage compensation. Further, we have elucidated that epigenetic regulation-DNA methylation and microRNAs (miRNAs)-likely underlies the transcriptional changes observed. This study suggests that exposures to exogenous compounds during preimplantation may unintentionally reprogram the human embryo, possibly leading to suboptimal development and longer-term health outcomes." @default.
- W4290927211 created "2022-08-13" @default.
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- W4290927211 date "2022-08-10" @default.
- W4290927211 modified "2023-10-14" @default.
- W4290927211 title "Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids" @default.
- W4290927211 cites W1494889139 @default.
- W4290927211 cites W1709815505 @default.
- W4290927211 cites W1968116524 @default.
- W4290927211 cites W1979141874 @default.
- W4290927211 cites W1986062308 @default.
- W4290927211 cites W2007439698 @default.
- W4290927211 cites W2012270463 @default.
- W4290927211 cites W2018941771 @default.
- W4290927211 cites W2030655597 @default.
- W4290927211 cites W2033139829 @default.
- W4290927211 cites W2036111380 @default.
- W4290927211 cites W2036153065 @default.
- W4290927211 cites W2047333953 @default.
- W4290927211 cites W2047355421 @default.
- W4290927211 cites W2047958761 @default.
- W4290927211 cites W2050044795 @default.
- W4290927211 cites W2055971382 @default.
- W4290927211 cites W2059687540 @default.
- W4290927211 cites W2068160958 @default.
- W4290927211 cites W2068767807 @default.
- W4290927211 cites W2077283526 @default.
- W4290927211 cites W2078663366 @default.
- W4290927211 cites W2084608054 @default.
- W4290927211 cites W2088592220 @default.
- W4290927211 cites W2095265297 @default.
- W4290927211 cites W2102478174 @default.
- W4290927211 cites W2114970231 @default.
- W4290927211 cites W2119502220 @default.
- W4290927211 cites W2121417064 @default.
- W4290927211 cites W2123032740 @default.
- W4290927211 cites W2124050695 @default.
- W4290927211 cites W2125336256 @default.
- W4290927211 cites W2129574905 @default.
- W4290927211 cites W2129930491 @default.
- W4290927211 cites W2135707932 @default.
- W4290927211 cites W2140995557 @default.
- W4290927211 cites W2152735385 @default.
- W4290927211 cites W2155675381 @default.
- W4290927211 cites W2156808865 @default.
- W4290927211 cites W2157132098 @default.
- W4290927211 cites W2158948118 @default.
- W4290927211 cites W2169456326 @default.
- W4290927211 cites W2169913308 @default.
- W4290927211 cites W2190545194 @default.
- W4290927211 cites W2222000795 @default.
- W4290927211 cites W2316095770 @default.
- W4290927211 cites W2324325083 @default.
- W4290927211 cites W2394611172 @default.
- W4290927211 cites W2491109187 @default.
- W4290927211 cites W2545155109 @default.
- W4290927211 cites W2549616490 @default.
- W4290927211 cites W2564487483 @default.
- W4290927211 cites W2586644020 @default.
- W4290927211 cites W2592627283 @default.
- W4290927211 cites W2602685374 @default.
- W4290927211 cites W2610903912 @default.
- W4290927211 cites W2612537088 @default.
- W4290927211 cites W2624228281 @default.
- W4290927211 cites W2762894765 @default.
- W4290927211 cites W2765281056 @default.
- W4290927211 cites W2778932546 @default.
- W4290927211 cites W2787931223 @default.
- W4290927211 cites W2792647356 @default.
- W4290927211 cites W2806522278 @default.
- W4290927211 cites W2890548015 @default.
- W4290927211 cites W2892880026 @default.
- W4290927211 cites W2917672488 @default.
- W4290927211 cites W2949177718 @default.
- W4290927211 cites W2955023201 @default.
- W4290927211 cites W2969627797 @default.
- W4290927211 cites W2996524386 @default.
- W4290927211 cites W3000840492 @default.
- W4290927211 cites W3006653136 @default.
- W4290927211 cites W3012944064 @default.
- W4290927211 cites W3023998386 @default.
- W4290927211 cites W3025370997 @default.
- W4290927211 cites W3092415745 @default.
- W4290927211 cites W3098174279 @default.
- W4290927211 cites W3137762429 @default.
- W4290927211 cites W3161732928 @default.