FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290929887> ?p ?o ?g. }

• W4290929887 endingPage "275" @default.
• W4290929887 startingPage "262" @default.
• W4290929887 abstract "Type Ib glycogen storage disease (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate (G6P) transporter (G6PT) that translocates G6P from the cytoplasm into the endoplasmic reticulum lumen, where the intraluminal G6P is hydrolyzed to glucose by glucose-6-phosphatase-α (G6Pase-α). Clinically, GSD-Ib patients manifest a metabolic phenotype of impaired blood glucose homeostasis and a long-term risk of hepatocellular adenoma/carcinoma (HCA/HCC). Studies have shown that autophagy deficiency contributes to hepatocarcinogenesis. In this study, we show that G6PT deficiency leads to impaired hepatic autophagy evident from attenuated expression of many components of the autophagy network, decreased autophagosome formation and reduced autophagy flux. The G6PT-deficient liver displayed impaired sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) signaling, along with reduced expression of SIRT1, forkhead boxO3a (FoxO3a), liver kinase B-1 (LKB1) and the active p-AMPK. Importantly, we show that overexpression of either SIRT1 or LKB1 in G6PT-deficient liver restored autophagy and SIRT1/FoxO3a and LKB1/AMPK signaling. The hepatosteatosis in G6PT-deficient liver decreased SIRT1 expression. LKB1 overexpression reduced hepatic triglyceride levels, providing a potential link between LKB1/AMPK signaling upregulation and the increase in SIRT1 expression. In conclusion, downregulation of SIRT1/FoxO3a and LKB1/AMPK signaling underlies impaired hepatic autophagy which may contribute to HCA/HCC development in GSD-Ib. Understanding this mechanism may guide future therapies." @default.
• W4290929887 created "2022-08-13" @default.
• W4290929887 creator A5033006726 @default.
• W4290929887 creator A5044410528 @default.
• W4290929887 creator A5052557750 @default.
• W4290929887 creator A5058459841 @default.
• W4290929887 creator A5059628530 @default.
• W4290929887 creator A5060590657 @default.
• W4290929887 creator A5069217915 @default.
• W4290929887 creator A5079454405 @default.
• W4290929887 creator A5089637454 @default.
• W4290929887 date "2022-08-12" @default.
• W4290929887 modified "2023-10-14" @default.
• W4290929887 title "Molecular mechanism underlying impaired hepatic autophagy in glycogen storage disease type Ib" @default.
• W4290929887 cites W1762190809 @default.
• W4290929887 cites W1845621716 @default.
• W4290929887 cites W1931704533 @default.
• W4290929887 cites W1979783084 @default.
• W4290929887 cites W1980084094 @default.
• W4290929887 cites W1985124617 @default.
• W4290929887 cites W1989692826 @default.
• W4290929887 cites W1992304595 @default.
• W4290929887 cites W2002226709 @default.
• W4290929887 cites W2007743440 @default.
• W4290929887 cites W2009559888 @default.
• W4290929887 cites W2010238890 @default.
• W4290929887 cites W2015022497 @default.
• W4290929887 cites W2016294119 @default.
• W4290929887 cites W2016505696 @default.
• W4290929887 cites W2018964373 @default.
• W4290929887 cites W2022267544 @default.
• W4290929887 cites W2028260889 @default.
• W4290929887 cites W2051584795 @default.
• W4290929887 cites W2102614059 @default.
• W4290929887 cites W2112672158 @default.
• W4290929887 cites W2135476952 @default.
• W4290929887 cites W2140406095 @default.
• W4290929887 cites W2152602200 @default.
• W4290929887 cites W2171729436 @default.
• W4290929887 cites W2317113145 @default.
• W4290929887 cites W2462514513 @default.
• W4290929887 cites W2592437910 @default.
• W4290929887 cites W2617557417 @default.
• W4290929887 cites W2748137738 @default.
• W4290929887 cites W2750463325 @default.
• W4290929887 cites W2809812837 @default.
• W4290929887 cites W2901164269 @default.
• W4290929887 cites W2902863353 @default.
• W4290929887 cites W2946950712 @default.
• W4290929887 cites W3002738481 @default.
• W4290929887 cites W4233460988 @default.
• W4290929887 doi "https://doi.org/10.1093/hmg/ddac197" @default.
• W4290929887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35961004" @default.
• W4290929887 hasPublicationYear "2022" @default.
• W4290929887 type Work @default.
• W4290929887 citedByCount "3" @default.
• W4290929887 countsByYear W42909298872023 @default.
• W4290929887 crossrefType "journal-article" @default.
• W4290929887 hasAuthorship W4290929887A5033006726 @default.
• W4290929887 hasAuthorship W4290929887A5044410528 @default.
• W4290929887 hasAuthorship W4290929887A5052557750 @default.
• W4290929887 hasAuthorship W4290929887A5058459841 @default.
• W4290929887 hasAuthorship W4290929887A5059628530 @default.
• W4290929887 hasAuthorship W4290929887A5060590657 @default.
• W4290929887 hasAuthorship W4290929887A5069217915 @default.
• W4290929887 hasAuthorship W4290929887A5079454405 @default.
• W4290929887 hasAuthorship W4290929887A5089637454 @default.
• W4290929887 hasBestOaLocation W42909298871 @default.
• W4290929887 hasConcept C104317684 @default.
• W4290929887 hasConcept C126322002 @default.
• W4290929887 hasConcept C127561419 @default.
• W4290929887 hasConcept C134018914 @default.
• W4290929887 hasConcept C184235292 @default.
• W4290929887 hasConcept C190283241 @default.
• W4290929887 hasConcept C203522944 @default.
• W4290929887 hasConcept C2776175330 @default.
• W4290929887 hasConcept C2776536020 @default.
• W4290929887 hasConcept C2776780712 @default.
• W4290929887 hasConcept C2778772119 @default.
• W4290929887 hasConcept C2779134260 @default.
• W4290929887 hasConcept C2780124434 @default.
• W4290929887 hasConcept C502942594 @default.
• W4290929887 hasConcept C55493867 @default.
• W4290929887 hasConcept C71924100 @default.
• W4290929887 hasConcept C86803240 @default.
• W4290929887 hasConcept C95444343 @default.
• W4290929887 hasConcept C97029542 @default.
• W4290929887 hasConceptScore W4290929887C104317684 @default.
• W4290929887 hasConceptScore W4290929887C126322002 @default.
• W4290929887 hasConceptScore W4290929887C127561419 @default.
• W4290929887 hasConceptScore W4290929887C134018914 @default.
• W4290929887 hasConceptScore W4290929887C184235292 @default.
• W4290929887 hasConceptScore W4290929887C190283241 @default.
• W4290929887 hasConceptScore W4290929887C203522944 @default.
• W4290929887 hasConceptScore W4290929887C2776175330 @default.
• W4290929887 hasConceptScore W4290929887C2776536020 @default.
• W4290929887 hasConceptScore W4290929887C2776780712 @default.
• W4290929887 hasConceptScore W4290929887C2778772119 @default.

• next