Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290930092> ?p ?o ?g. }
- W4290930092 abstract "The interaction of evolutionary processes to determine quantitative genetic variation has implications for contemporary and future phenotypic evolution, as well as for our ability to detect causal genetic variants. While theoretical studies have provided robust predictions to discriminate among competing models, empirical assessment of these has been limited. In particular, theory highlights the importance of pleiotropy in resolving observations of selection and mutation, but empirical investigations have typically been limited to few traits. Here, we applied high-dimensional Bayesian Sparse Factor Genetic modeling to gene expression datasets in 2 species, Drosophila melanogaster and Drosophila serrata, to explore the distributions of genetic variance across high-dimensional phenotypic space. Surprisingly, most of the heritable trait covariation was due to few lines (genotypes) with extreme [>3 interquartile ranges (IQR) from the median] values. Intriguingly, while genotypes extreme for a multivariate factor also tended to have a higher proportion of individual traits that were extreme, we also observed genotypes that were extreme for multivariate factors but not for any individual trait. We observed other consistent differences between heritable multivariate factors with outlier lines vs those factors without extreme values, including differences in gene functions. We use these observations to identify further data required to advance our understanding of the evolutionary dynamics and nature of standing genetic variation for quantitative traits." @default.
- W4290930092 created "2022-08-13" @default.
- W4290930092 creator A5017400602 @default.
- W4290930092 creator A5021085547 @default.
- W4290930092 creator A5030550139 @default.
- W4290930092 creator A5035695817 @default.
- W4290930092 creator A5038094854 @default.
- W4290930092 creator A5079313615 @default.
- W4290930092 creator A5080344032 @default.
- W4290930092 date "2022-08-12" @default.
- W4290930092 modified "2023-10-01" @default.
- W4290930092 title "Maintenance of quantitative genetic variance in complex, multitrait phenotypes: the contribution of rare, large effect variants in 2 Drosophila species" @default.
- W4290930092 cites W1520752838 @default.
- W4290930092 cites W1556388014 @default.
- W4290930092 cites W1625086225 @default.
- W4290930092 cites W1877460931 @default.
- W4290930092 cites W1897869592 @default.
- W4290930092 cites W1955170827 @default.
- W4290930092 cites W1978697143 @default.
- W4290930092 cites W1981831435 @default.
- W4290930092 cites W1983113601 @default.
- W4290930092 cites W1985211888 @default.
- W4290930092 cites W1988635986 @default.
- W4290930092 cites W1991431672 @default.
- W4290930092 cites W1996541678 @default.
- W4290930092 cites W2012139697 @default.
- W4290930092 cites W2024522870 @default.
- W4290930092 cites W2029721016 @default.
- W4290930092 cites W2036808380 @default.
- W4290930092 cites W2038522196 @default.
- W4290930092 cites W2055043387 @default.
- W4290930092 cites W2062210712 @default.
- W4290930092 cites W2077723503 @default.
- W4290930092 cites W2081778879 @default.
- W4290930092 cites W2086391970 @default.
- W4290930092 cites W2088014737 @default.
- W4290930092 cites W2090853729 @default.
- W4290930092 cites W2094248448 @default.
- W4290930092 cites W2100761975 @default.
- W4290930092 cites W2100874076 @default.
- W4290930092 cites W2102907886 @default.
- W4290930092 cites W2104363774 @default.
- W4290930092 cites W2107281207 @default.
- W4290930092 cites W2111637141 @default.
- W4290930092 cites W2111960876 @default.
- W4290930092 cites W2114632170 @default.
- W4290930092 cites W2117640993 @default.
- W4290930092 cites W2117925179 @default.
- W4290930092 cites W2117993464 @default.
- W4290930092 cites W2122476222 @default.
- W4290930092 cites W2125905177 @default.
- W4290930092 cites W2126015874 @default.
- W4290930092 cites W2130939625 @default.
- W4290930092 cites W2132338245 @default.
- W4290930092 cites W2133675997 @default.
- W4290930092 cites W2139079568 @default.
- W4290930092 cites W2140024267 @default.
- W4290930092 cites W2144961623 @default.
- W4290930092 cites W2148115437 @default.
- W4290930092 cites W2149943693 @default.
- W4290930092 cites W2150433838 @default.
- W4290930092 cites W2155366287 @default.
- W4290930092 cites W2155833028 @default.
- W4290930092 cites W2157983809 @default.
- W4290930092 cites W2158084232 @default.
- W4290930092 cites W2159707462 @default.
- W4290930092 cites W2161348391 @default.
- W4290930092 cites W2166039733 @default.
- W4290930092 cites W2177081428 @default.
- W4290930092 cites W2184370715 @default.
- W4290930092 cites W2195783463 @default.
- W4290930092 cites W2269787281 @default.
- W4290930092 cites W2521004108 @default.
- W4290930092 cites W2560604625 @default.
- W4290930092 cites W2753046929 @default.
- W4290930092 cites W2765606673 @default.
- W4290930092 cites W2768144164 @default.
- W4290930092 cites W2791118826 @default.
- W4290930092 cites W2792771548 @default.
- W4290930092 cites W2806365184 @default.
- W4290930092 cites W2811460312 @default.
- W4290930092 cites W2891696188 @default.
- W4290930092 cites W2899600207 @default.
- W4290930092 cites W2908303872 @default.
- W4290930092 cites W2914532656 @default.
- W4290930092 cites W2940517989 @default.
- W4290930092 cites W2944545583 @default.
- W4290930092 cites W2949399278 @default.
- W4290930092 cites W2949830473 @default.
- W4290930092 cites W2951819183 @default.
- W4290930092 cites W2952596465 @default.
- W4290930092 cites W2960985920 @default.
- W4290930092 cites W2970142068 @default.
- W4290930092 cites W2977429831 @default.
- W4290930092 cites W2982183508 @default.
- W4290930092 cites W3001162402 @default.
- W4290930092 cites W3022572641 @default.
- W4290930092 cites W3072691728 @default.
- W4290930092 cites W3103040926 @default.
- W4290930092 cites W3127976471 @default.