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- W4290973440 abstract "Mucus abnormalities play important roles in the development and/or evolution of most, if not all, airway diseases. The airway mucus is both a crucial component of the airway's mechanical defence mechanisms against irritants and microorganisms, and a marker of airway injury: its composition is influenced by various pathophysiological mechanisms involved in acute and chronic airway diseases, including inflammation, infection, oxidative stress and protease–antiprotease imbalance. These mechanisms can induce abnormalities in mucus composition through impairments in mucin production and/or ion transport pathways that contribute to mucus hydration [1], and/or through the integration in the mucus of other components, such as extracellular DNA and other constituents of neutrophil extracellular traps. The contribution of CFTR to the pathobiology of cigarette smoke-related chronic airway diseases deserves further investigation <https://bit.ly/3FvP5Ym>" @default.
- W4290973440 created "2022-08-13" @default.
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- W4290973440 date "2022-08-01" @default.
- W4290973440 modified "2023-10-17" @default.
- W4290973440 title "Cystic fibrosis transmembrane conductance regulator (CFTR): a missing link between smoking and chronic airway diseases?" @default.
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- W4290973440 doi "https://doi.org/10.1183/13993003.00898-2022" @default.
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