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- W4290973460 endingPage "e1010331" @default.
- W4290973460 startingPage "e1010331" @default.
- W4290973460 abstract "Eukaryotic circadian clocks are based on self-sustaining, cell-autonomous oscillatory feedback loops that can synchronize with the environment via recurrent stimuli (zeitgebers) such as light. The components of biological clocks and their network interactions are becoming increasingly known, calling for a quantitative understanding of their role for clock function. However, the development of data-driven mathematical clock models has remained limited by the lack of sufficiently accurate data. Here we present a comprehensive model of the circadian clock of Neurospora crassa that describe free-running oscillations in constant darkness and entrainment in light-dark cycles. To parameterize the model, we measured high-resolution time courses of luciferase reporters of morning and evening specific clock genes in WT and a mutant strain. Fitting the model to such comprehensive data allowed estimating parameters governing circadian phase, period length and amplitude, and the response of genes to light cues. Our model suggests that functional maturation of the core clock protein Frequency causes a delay in negative feedback that is critical for generating circadian rhythms." @default.
- W4290973460 created "2022-08-13" @default.
- W4290973460 creator A5017280200 @default.
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- W4290973460 creator A5022095447 @default.
- W4290973460 creator A5023235079 @default.
- W4290973460 creator A5050099178 @default.
- W4290973460 date "2022-08-11" @default.
- W4290973460 modified "2023-10-14" @default.
- W4290973460 title "Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa" @default.
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