FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290973973> ?p ?o ?g. }

• W4290973973 endingPage "2295" @default.
• W4290973973 startingPage "2277" @default.
• W4290973973 abstract "The impact of gut microbiota-targeted interventions on the incidence, duration, and severity of respiratory tract infections (RTI) in non-elderly adults, and factors moderating any such effects, are unclear. This systematic review and meta-analysis aimed to determine the effects of orally ingested probiotics, prebiotics, and synbiotics versus placebo on RTI incidence, duration, and severity in non-elderly adults, and to identify potential sources of heterogeneity. Studies were identified by searching CENTRAL, PubMed, Scopus, and Web of Science up to December 2021. English-language peer-reviewed publications of randomized, placebo-controlled studies that tested an orally ingested probiotic, prebiotic or synbiotic intervention of any dose for ≥ 1 week in adults 18–65 yr were included. Results were synthesized using intention-to-treat and per protocol random effects meta-analysis. Heterogeneity was explored by sub-group meta-analysis and meta-regression. Risk of bias (RoB) was assessed using the Cochrane RoBv.2 tool for randomized trials. Forty-two manuscripts reporting effects of probiotics (n = 38), prebiotics (n = 2), synbiotics (n = 1) or multiple -biotic types (n = 1) were identified (n = 9,179 subjects). Probiotics reduced the risk of experiencing ≥ 1 RTI (relative risk = 0.91 [95%CI: 0.84, 0.98] P = 0.01), and total days (rate ratio = 0.77 [0.71, 0.83] P < 0.001), duration (Hedges's g = -0.23 [-0.39, -0.08] P = 0.004) and severity (Hedges's g = -0.16 [-0.29, -0.03] P = 0.02) of RTI. Effects were relatively consistent across different strain combinations, doses and durations, though reductions in RTI duration were larger with fermented dairy as the delivery matrix, and beneficial effects of probiotics were not observed in physically active populations. Overall RoB was rated as “some concerns for most studies. Orally ingested probiotics, relative to placebo, modestly reduce the incidence, duration and severity of RTI in non-elderly adults. Physical activity and delivery matrix may moderate some of these effects. Whether prebiotic and synbiotic interventions confer similar protection remains unclear due to few relevant studies. PROSPERO registration: CRD42020220213" @default.
• W4290973973 created "2022-08-13" @default.
• W4290973973 creator A5001150142 @default.
• W4290973973 creator A5027624455 @default.
• W4290973973 creator A5031335069 @default.
• W4290973973 creator A5036956446 @default.
• W4290973973 creator A5037812489 @default.
• W4290973973 creator A5076982751 @default.
• W4290973973 creator A5086487473 @default.
• W4290973973 creator A5088653485 @default.
• W4290973973 creator A5090277382 @default.
• W4290973973 date "2022-11-01" @default.
• W4290973973 modified "2023-10-12" @default.
• W4290973973 title "Orally Ingested Probiotics, Prebiotics, and Synbiotics as Countermeasures for Respiratory Tract Infections in Nonelderly Adults: A Systematic Review and Meta-Analysis" @default.
• W4290973973 cites W1495518424 @default.
• W4290973973 cites W1603748631 @default.
• W4290973973 cites W1822991126 @default.
• W4290973973 cites W1957322304 @default.
• W4290973973 cites W1959094227 @default.
• W4290973973 cites W1982684416 @default.
• W4290973973 cites W1999138960 @default.
• W4290973973 cites W2003716831 @default.
• W4290973973 cites W2004604828 @default.
• W4290973973 cites W2022579357 @default.
• W4290973973 cites W2029262201 @default.
• W4290973973 cites W2042316472 @default.
• W4290973973 cites W2050410034 @default.
• W4290973973 cites W2051611990 @default.
• W4290973973 cites W2053559292 @default.
• W4290973973 cites W2090165327 @default.
• W4290973973 cites W2095601341 @default.
• W4290973973 cites W2104181007 @default.
• W4290973973 cites W2106310144 @default.
• W4290973973 cites W2107533173 @default.
• W4290973973 cites W2114488493 @default.
• W4290973973 cites W2114489487 @default.
• W4290973973 cites W2116436375 @default.
• W4290973973 cites W2149074973 @default.
• W4290973973 cites W2149456845 @default.
• W4290973973 cites W2152193038 @default.
• W4290973973 cites W2154997613 @default.
• W4290973973 cites W2155413133 @default.
• W4290973973 cites W2157823046 @default.
• W4290973973 cites W2160362327 @default.
• W4290973973 cites W2168275695 @default.
• W4290973973 cites W2178038387 @default.
• W4290973973 cites W2189994874 @default.
• W4290973973 cites W2260645575 @default.
• W4290973973 cites W2297270625 @default.
• W4290973973 cites W2300829760 @default.
• W4290973973 cites W2321137130 @default.
• W4290973973 cites W2326424980 @default.
• W4290973973 cites W2331252826 @default.
• W4290973973 cites W2395514413 @default.
• W4290973973 cites W2441014991 @default.
• W4290973973 cites W2499847296 @default.
• W4290973973 cites W2529520145 @default.
• W4290973973 cites W2552273282 @default.
• W4290973973 cites W2564925030 @default.
• W4290973973 cites W2600856580 @default.
• W4290973973 cites W2616825195 @default.
• W4290973973 cites W2627092521 @default.
• W4290973973 cites W2694487218 @default.
• W4290973973 cites W2753051611 @default.
• W4290973973 cites W2789836858 @default.
• W4290973973 cites W2793051982 @default.
• W4290973973 cites W2911221302 @default.
• W4290973973 cites W2914551241 @default.
• W4290973973 cites W2931452593 @default.
• W4290973973 cites W2933130235 @default.
• W4290973973 cites W2956175090 @default.
• W4290973973 cites W2962877753 @default.
• W4290973973 cites W2970684805 @default.
• W4290973973 cites W2982405140 @default.
• W4290973973 cites W2996536203 @default.
• W4290973973 cites W3004272373 @default.
• W4290973973 cites W3009088635 @default.
• W4290973973 cites W3010055553 @default.
• W4290973973 cites W3017301900 @default.
• W4290973973 cites W3035471962 @default.
• W4290973973 cites W3036283563 @default.
• W4290973973 cites W3089310389 @default.
• W4290973973 cites W3095471141 @default.
• W4290973973 cites W3096809221 @default.
• W4290973973 cites W3111205743 @default.
• W4290973973 cites W3117454198 @default.
• W4290973973 cites W3119286420 @default.
• W4290973973 cites W3124420833 @default.
• W4290973973 cites W3135877796 @default.
• W4290973973 cites W3174780411 @default.
• W4290973973 cites W3200940762 @default.
• W4290973973 doi "https://doi.org/10.1093/advances/nmac086" @default.
• W4290973973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35948276" @default.
• W4290973973 hasPublicationYear "2022" @default.
• W4290973973 type Work @default.
• W4290973973 citedByCount "4" @default.
• W4290973973 countsByYear W42909739732023 @default.
• W4290973973 crossrefType "journal-article" @default.

• next