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- W42909765 abstract "Several studies have shown impairment of neutrophil function that leads to high incidence of infections in diabetes. Neutrophils obtained from streptozotocin (STZ)-induced diabetic male Wistar rats (65mg/Kg b.w, 6 weeks) were investigated. Diabetic (D) and control (C) rats received an intraperitoneal injection of glycogen solution (1%). After 4 hours, the following parameters were measured: total cell counts in peritoneal lavage; apoptosis process in neutrophils by flow cytometry; activities of caspases 3, 8 and 9 by fluorimeter and expression of the Bax, Fas, p53 and beta2M were also determined by real-time PCR. Neutrophils from diabetic rats presented a decrease in cell viability and an increase of DNA fragmentation. Phosphatidylserine externalization was observed at the same proportion in neutrophils of C, D and treated D. The caspase 8 activity was decreased (10%) in neutrophils from D rats and these cells presented an increase of caspase 9 activity (26%), whereas the caspase 3 activity was not changed. Neutrophils from D rats presented markedly increased in Bax (9x), Fas (12x) and p53 (13x) mRNA expression. Neutrophils from D treated with insulin (2 to 4 UI/ day) during 6 weeks presented the same changes of the cells from C rat. Therefore, diabetic state induces marked changes in neutrophil apoptosis and this may be important for the impairment in neutrophil function observed under these conditions. Research support by: FAPESP and CNPq" @default.
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- W42909765 date "2007-01-01" @default.
- W42909765 modified "2023-10-16" @default.
- W42909765 title "Apoptosis of Neutrophils from Diabetic rats" @default.
- W42909765 doi "https://doi.org/10.1096/fasebj.21.6.a1346" @default.
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