FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290988377> ?p ?o ?g. }

• W4290988377 abstract "Abstract Background For almost a century, it has been recognized that influenza A virus (IAV) infection can promote the development of secondary bacterial infections (SBI) mainly caused by Streptococcus pneumoniae ( Spn ). Recent observations have shown that IAV is able to directly bind to the surface of Spn . To gain a foundational understanding of how direct IAV- Spn interaction alters bacterial biological fitness we employed combinatorial multi-omic and molecular approaches. Results Here we show IAV significantly remodels the global transcriptome, proteome and phosphoproteome profiles of Spn independently of host effectors. We identified Spn surface proteins that interact with IAV proteins (hemagglutinin, nucleoprotein, and neuraminidase). In addition, IAV was found to directly modulate expression of Spn virulence determinants such as pneumococcal surface protein A, pneumolysin, and factors associated with antimicrobial resistance among many others. Metabolic pathways were significantly altered leading to changes in Spn growth rate. IAV was also found to drive Spn capsule shedding and the release of pneumococcal surface proteins. Released proteins were found to be involved in evasion of innate immune responses and actively reduced human complement hemolytic and opsonizing activity. IAV also led to phosphorylation changes in Spn proteins associated with metabolism and bacterial virulence. Validation of proteomic data showed significant changes in Spn galactose and glucose metabolism. Furthermore, supplementation with galactose rescued bacterial growth and promoted bacterial invasion, while glucose supplementation led to enhanced pneumolysin production and lung cell apoptosis. Conclusions Here we demonstrate that IAV can directly modulate Spn biology without the requirement of host effectors and support the notion that inter-kingdom interactions between human viruses and commensal pathobionts can promote bacterial pathogenesis and microbiome dysbiosis." @default.
• W4290988377 created "2022-08-13" @default.
• W4290988377 creator A5013303120 @default.
• W4290988377 creator A5026992121 @default.
• W4290988377 creator A5027035037 @default.
• W4290988377 creator A5027189626 @default.
• W4290988377 creator A5060394883 @default.
• W4290988377 creator A5073251151 @default.
• W4290988377 creator A5074305003 @default.
• W4290988377 creator A5082903195 @default.
• W4290988377 creator A5088299573 @default.
• W4290988377 date "2022-08-08" @default.
• W4290988377 modified "2023-10-17" @default.
• W4290988377 title "A multiomics analysis of direct interkingdom dynamics between influenza A virus and <i>Streptococcus pneumoniae</i> uncovers host-independent changes to bacterial virulence fitness" @default.
• W4290988377 cites W1914172730 @default.
• W4290988377 cites W1967386006 @default.
• W4290988377 cites W1968211934 @default.
• W4290988377 cites W1969520497 @default.
• W4290988377 cites W1974058521 @default.
• W4290988377 cites W1986355672 @default.
• W4290988377 cites W1986787331 @default.
• W4290988377 cites W1989088567 @default.
• W4290988377 cites W1993643129 @default.
• W4290988377 cites W1995536796 @default.
• W4290988377 cites W2000714505 @default.
• W4290988377 cites W2008722826 @default.
• W4290988377 cites W2014197969 @default.
• W4290988377 cites W2016809667 @default.
• W4290988377 cites W2018376905 @default.
• W4290988377 cites W2024812631 @default.
• W4290988377 cites W2036192752 @default.
• W4290988377 cites W2038140390 @default.
• W4290988377 cites W2042044881 @default.
• W4290988377 cites W2042894911 @default.
• W4290988377 cites W2043794217 @default.
• W4290988377 cites W2045227909 @default.
• W4290988377 cites W2045604609 @default.
• W4290988377 cites W2054167525 @default.
• W4290988377 cites W2055212290 @default.
• W4290988377 cites W2062812161 @default.
• W4290988377 cites W2063890366 @default.
• W4290988377 cites W2068862934 @default.
• W4290988377 cites W2076298858 @default.
• W4290988377 cites W2080198152 @default.
• W4290988377 cites W2082014384 @default.
• W4290988377 cites W2088681575 @default.
• W4290988377 cites W2088939150 @default.
• W4290988377 cites W2089934202 @default.
• W4290988377 cites W2096423428 @default.
• W4290988377 cites W2098667134 @default.
• W4290988377 cites W2104726963 @default.
• W4290988377 cites W2106121680 @default.
• W4290988377 cites W2106850668 @default.
• W4290988377 cites W2110719496 @default.
• W4290988377 cites W2111775856 @default.
• W4290988377 cites W2116857869 @default.
• W4290988377 cites W2119403223 @default.
• W4290988377 cites W2121103946 @default.
• W4290988377 cites W2121163342 @default.
• W4290988377 cites W2121263909 @default.
• W4290988377 cites W2123606871 @default.
• W4290988377 cites W2128374872 @default.
• W4290988377 cites W2129110178 @default.
• W4290988377 cites W2129382845 @default.
• W4290988377 cites W2132077883 @default.
• W4290988377 cites W2132219663 @default.
• W4290988377 cites W2140155593 @default.
• W4290988377 cites W2140454611 @default.
• W4290988377 cites W2144240057 @default.
• W4290988377 cites W2144449002 @default.
• W4290988377 cites W2145435157 @default.
• W4290988377 cites W2147140573 @default.
• W4290988377 cites W2148711203 @default.
• W4290988377 cites W2151552877 @default.
• W4290988377 cites W2152245352 @default.
• W4290988377 cites W2153399124 @default.
• W4290988377 cites W2154385325 @default.
• W4290988377 cites W2156980684 @default.
• W4290988377 cites W2162503698 @default.
• W4290988377 cites W2162620711 @default.
• W4290988377 cites W2162953780 @default.
• W4290988377 cites W2164333050 @default.
• W4290988377 cites W2167152465 @default.
• W4290988377 cites W2167500590 @default.
• W4290988377 cites W2170629825 @default.
• W4290988377 cites W2170776626 @default.
• W4290988377 cites W2220848304 @default.
• W4290988377 cites W2233212863 @default.
• W4290988377 cites W2239245460 @default.
• W4290988377 cites W2292669177 @default.
• W4290988377 cites W2317658790 @default.
• W4290988377 cites W2327360668 @default.
• W4290988377 cites W2330161102 @default.
• W4290988377 cites W2342564628 @default.
• W4290988377 cites W2400673380 @default.
• W4290988377 cites W2462988754 @default.
• W4290988377 cites W2544360569 @default.
• W4290988377 cites W2559943160 @default.
• W4290988377 cites W2563859344 @default.
• W4290988377 cites W2591998214 @default.

• next