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• W4290988839 abstract "The aim of this study was to identify a probiotic-based strategy for maintaining muscle anabolism in the elderly. In previous research, we found that individuals experiencing short bowel syndrome (SBS) after an intestinal resection displayed beneficial metabolic adjustments that were mediated by their gut microbes. Thus, these bacteria could potentially be used to elicit similar positive effects in elderly people, who often have low food intake and thus develop sarcopenia. Gut bacterial strains from an SBS patient were evaluated for their ability to (1) maintain Caenorhabditis elegans survival and muscle structure and (2) promote protein anabolism in a model of frail rodents (18-month-old rats on a food-restricted diet: 75% of ad libitum consumption). We screened a first set of bacteria in C. elegans and selected two Lacticaseibacillus casei strains (62 and 63) for further testing in the rat model. We had four experimental groups: control rats on an ad libitum diet (AL); non-supplemented rats on the food-restricted diet (R); and two sets of food-restricted rats that received a daily supplement of one of the strains (∼10 9 CFU; R+62 and R+63). We measured lean mass, protein metabolism, insulin resistance, cecal short-chain fatty acids (SCFAs), and SCFA receptor expression in the gut. Food restriction led to decreased muscle mass [−10% vs. AL ( p &lt; 0.05)]. Supplementation with strain 63 tempered this effect [−2% vs. AL ( p &gt; 0.1)]. The mechanism appeared to be the stimulation of the insulin-sensitive p-S6/S6 and p-eIF2α/eIF2α ratios, which were similar in the R+63 and AL groups ( p &gt; 0.1) but lower in the R group ( p &lt; 0.05). We hypothesize that greater SCFA receptor sensitivity in the R+63 group promoted gut-muscle cross talk [GPR41: +40% and GPR43: +47% vs. R ( p &lt; 0.05)]. Hence, strain 63 could be used in association with other nutritional strategies and exercise regimes to limit sarcopenia in frail elderly people." @default.
• W4290988839 created "2022-08-13" @default.
• W4290988839 creator A5000624891 @default.
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• W4290988839 date "2022-08-10" @default.
• W4290988839 modified "2023-10-12" @default.
• W4290988839 title "Lacticaseibacillus casei CNCM I-5663 supplementation maintained muscle mass in a model of frail rodents" @default.
• W4290988839 cites W1541292363 @default.
• W4290988839 cites W1577108907 @default.
• W4290988839 cites W1966921473 @default.
• W4290988839 cites W1967596657 @default.
• W4290988839 cites W1979080859 @default.
• W4290988839 cites W1980423331 @default.
• W4290988839 cites W2003708547 @default.
• W4290988839 cites W2020203688 @default.
• W4290988839 cites W2023925496 @default.
• W4290988839 cites W2028520715 @default.
• W4290988839 cites W2029119914 @default.
• W4290988839 cites W2035800002 @default.
• W4290988839 cites W2042074642 @default.
• W4290988839 cites W2063294396 @default.
• W4290988839 cites W2063299372 @default.
• W4290988839 cites W2079566818 @default.
• W4290988839 cites W2084831309 @default.
• W4290988839 cites W2088170171 @default.
• W4290988839 cites W2096423991 @default.
• W4290988839 cites W2101993054 @default.
• W4290988839 cites W2105503795 @default.
• W4290988839 cites W2124815398 @default.
• W4290988839 cites W2126923375 @default.
• W4290988839 cites W2129690444 @default.
• W4290988839 cites W2136417551 @default.
• W4290988839 cites W2137485729 @default.
• W4290988839 cites W2141125135 @default.
• W4290988839 cites W2147010636 @default.
• W4290988839 cites W2147790901 @default.
• W4290988839 cites W2164059021 @default.
• W4290988839 cites W2167062509 @default.
• W4290988839 cites W2184235212 @default.
• W4290988839 cites W2263333073 @default.
• W4290988839 cites W2290181911 @default.
• W4290988839 cites W2315432762 @default.
• W4290988839 cites W2464742226 @default.
• W4290988839 cites W2527872371 @default.
• W4290988839 cites W2583122059 @default.
• W4290988839 cites W2587430758 @default.
• W4290988839 cites W2591363413 @default.
• W4290988839 cites W2607503854 @default.
• W4290988839 cites W2620870153 @default.
• W4290988839 cites W2624858862 @default.
• W4290988839 cites W2765923427 @default.
• W4290988839 cites W2774437822 @default.
• W4290988839 cites W2897513125 @default.
• W4290988839 cites W2899146546 @default.
• W4290988839 cites W2900975761 @default.
• W4290988839 cites W2907243563 @default.
• W4290988839 cites W2908067737 @default.
• W4290988839 cites W2914899509 @default.
• W4290988839 cites W2947519079 @default.
• W4290988839 cites W2951273737 @default.
• W4290988839 cites W2954124338 @default.
• W4290988839 cites W2963465565 @default.
• W4290988839 cites W2965131971 @default.
• W4290988839 cites W2969326780 @default.
• W4290988839 cites W2969579790 @default.
• W4290988839 cites W2977490206 @default.
• W4290988839 cites W2983494012 @default.
• W4290988839 cites W2985101570 @default.
• W4290988839 cites W2990615003 @default.
• W4290988839 cites W2992403227 @default.
• W4290988839 cites W3000289408 @default.
• W4290988839 cites W3012435093 @default.
• W4290988839 cites W3015911247 @default.
• W4290988839 cites W3016017517 @default.
• W4290988839 cites W3024522054 @default.
• W4290988839 cites W3039026255 @default.
• W4290988839 cites W3064986956 @default.
• W4290988839 cites W3088203083 @default.
• W4290988839 cites W3101298242 @default.
• W4290988839 cites W3104518952 @default.
• W4290988839 cites W3111322366 @default.
• W4290988839 cites W3121032204 @default.
• W4290988839 cites W3133699935 @default.
• W4290988839 cites W3152793747 @default.
• W4290988839 cites W3178007684 @default.
• W4290988839 cites W3182329096 @default.
• W4290988839 cites W3199714171 @default.
• W4290988839 cites W3213272106 @default.
• W4290988839 cites W3213366591 @default.
• W4290988839 cites W4205123661 @default.
• W4290988839 cites W4213344577 @default.
• W4290988839 cites W4220770163 @default.

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