FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290989069> ?p ?o ?g. }

• W4290989069 endingPage "9148" @default.
• W4290989069 startingPage "9127" @default.
• W4290989069 abstract "Abstract The effects of rapid acute depletion of components of RNA polymerase II (Pol II) general transcription factors (GTFs) that are thought to be critical for formation of preinitiation complexes (PICs) and initiation in vitro were quantified in HAP1 cells using precision nuclear run-on sequencing (PRO-Seq). The average dependencies for each factor across &gt;70 000 promoters varied widely even though levels of depletions were similar. Some of the effects could be attributed to the presence or absence of core promoter elements such as the upstream TBP-specificity motif or downstream G-rich sequences, but some dependencies anti-correlated with such sequences. While depletion of TBP had a large effect on most Pol III promoters only a small fraction of Pol II promoters were similarly affected. TFIIB depletion had the largest general effect on Pol II and also correlated with apparent termination defects downstream of genes. Our results demonstrate that promoter activity is combinatorially influenced by recruitment of TFIID and sequence-specific transcription factors. They also suggest that interaction of the preinitiation complex (PIC) with nucleosomes can affect activity and that recruitment of TFIID containing TBP only plays a positive role at a subset of promoters." @default.
• W4290989069 created "2022-08-13" @default.
• W4290989069 creator A5002313521 @default.
• W4290989069 creator A5033719708 @default.
• W4290989069 creator A5051464082 @default.
• W4290989069 creator A5074762963 @default.
• W4290989069 creator A5084296716 @default.
• W4290989069 date "2022-08-10" @default.
• W4290989069 modified "2023-10-15" @default.
• W4290989069 title "Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB" @default.
• W4290989069 cites W1513355023 @default.
• W4290989069 cites W1549155795 @default.
• W4290989069 cites W1965485246 @default.
• W4290989069 cites W1973498182 @default.
• W4290989069 cites W1982826808 @default.
• W4290989069 cites W1985567287 @default.
• W4290989069 cites W1991864774 @default.
• W4290989069 cites W1999730696 @default.
• W4290989069 cites W2003168089 @default.
• W4290989069 cites W2011162627 @default.
• W4290989069 cites W2013980278 @default.
• W4290989069 cites W2015598927 @default.
• W4290989069 cites W2016786878 @default.
• W4290989069 cites W2019502407 @default.
• W4290989069 cites W2021943181 @default.
• W4290989069 cites W2033244846 @default.
• W4290989069 cites W2037429489 @default.
• W4290989069 cites W2040567801 @default.
• W4290989069 cites W2040922291 @default.
• W4290989069 cites W2041026268 @default.
• W4290989069 cites W2045074917 @default.
• W4290989069 cites W2051612352 @default.
• W4290989069 cites W2057228860 @default.
• W4290989069 cites W2062181306 @default.
• W4290989069 cites W2062865836 @default.
• W4290989069 cites W2062945095 @default.
• W4290989069 cites W2069610347 @default.
• W4290989069 cites W2070083583 @default.
• W4290989069 cites W2080757130 @default.
• W4290989069 cites W2081290562 @default.
• W4290989069 cites W2085428320 @default.
• W4290989069 cites W2087771505 @default.
• W4290989069 cites W2095799855 @default.
• W4290989069 cites W2096567462 @default.
• W4290989069 cites W2097920884 @default.
• W4290989069 cites W2098919421 @default.
• W4290989069 cites W2102619694 @default.
• W4290989069 cites W2105883156 @default.
• W4290989069 cites W2107042278 @default.
• W4290989069 cites W2116453847 @default.
• W4290989069 cites W2120100277 @default.
• W4290989069 cites W2124080033 @default.
• W4290989069 cites W2124985265 @default.
• W4290989069 cites W2128415323 @default.
• W4290989069 cites W2133449910 @default.
• W4290989069 cites W2152695978 @default.
• W4290989069 cites W2154998287 @default.
• W4290989069 cites W2156071334 @default.
• W4290989069 cites W2157702310 @default.
• W4290989069 cites W2158266834 @default.
• W4290989069 cites W2159422462 @default.
• W4290989069 cites W2165888235 @default.
• W4290989069 cites W2170154747 @default.
• W4290989069 cites W2173587434 @default.
• W4290989069 cites W2225270156 @default.
• W4290989069 cites W2308896320 @default.
• W4290989069 cites W2322970637 @default.
• W4290989069 cites W2406492422 @default.
• W4290989069 cites W2512782977 @default.
• W4290989069 cites W2557250028 @default.
• W4290989069 cites W2583542071 @default.
• W4290989069 cites W2745090396 @default.
• W4290989069 cites W2750519053 @default.
• W4290989069 cites W2796775019 @default.
• W4290989069 cites W2799762706 @default.
• W4290989069 cites W2807764897 @default.
• W4290989069 cites W2808119477 @default.
• W4290989069 cites W2896386781 @default.
• W4290989069 cites W2900974706 @default.
• W4290989069 cites W2901585851 @default.
• W4290989069 cites W2911925591 @default.
• W4290989069 cites W2912845458 @default.
• W4290989069 cites W2913823278 @default.
• W4290989069 cites W2951051180 @default.
• W4290989069 cites W2974660015 @default.
• W4290989069 cites W2984976925 @default.
• W4290989069 cites W2990523642 @default.
• W4290989069 cites W2991863328 @default.
• W4290989069 cites W3011916202 @default.
• W4290989069 cites W3014110333 @default.
• W4290989069 cites W3026275770 @default.
• W4290989069 cites W3030331522 @default.
• W4290989069 cites W3038060414 @default.
• W4290989069 cites W3082258871 @default.
• W4290989069 cites W3084020252 @default.
• W4290989069 cites W3087526660 @default.
• W4290989069 cites W3133792336 @default.
• W4290989069 cites W3147847912 @default.

• next