Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291002775> ?p ?o ?g. }
- W4291002775 endingPage "101110" @default.
- W4291002775 startingPage "101110" @default.
- W4291002775 abstract "Most human Siglecs (sialic acid binding immunoglobulin-like lectins) are expressed on the surfaces of overlapping subsets of immune cells, and most carry immunoreceptor tyrosine-based inhibitory domains on their intracellular motifs. When immune inhibitory Siglecs bind to complementary sialoglycans in their local milieu, engagement results in down-regulation of the immune response. Siglecs have come under scrutiny as potential targets of drugs to modify the course of inflammation (and other immune system responses) and as immune checkpoints in cancer. Human Siglecs bind to endogenous human sialoglycans. The identities of these endogenous human sialoglycan immune regulators are beginning to emerge, along with some general principles that may inform future investigations in this area. Among these principles is the finding that a cell type or tissue may express a ligand for a particular Siglec on a single or a very few of its sialoglycoproteins. The selected protein carrier for a particular Siglec may be unique in a certain tissue, but vary tissue-to-tissue. The binding affinity of endogenous Siglec ligands may surpass that of its binding to synthetic sialoglycan determinants by several orders of magnitude. Since most human Siglecs have evolved rapidly and are distinct from those in most other mammals, this review describes endogenous human Siglec ligands for several human immune inhibitory Siglecs. As the identities of these immune regulatory sialoglycan ligands are defined, additional opportunities to target Siglecs therapeutically may emerge." @default.
- W4291002775 created "2022-08-13" @default.
- W4291002775 creator A5007350640 @default.
- W4291002775 creator A5048314801 @default.
- W4291002775 creator A5068104814 @default.
- W4291002775 creator A5084167528 @default.
- W4291002775 date "2023-04-01" @default.
- W4291002775 modified "2023-10-18" @default.
- W4291002775 title "Human sialoglycan ligands for immune inhibitory Siglecs" @default.
- W4291002775 cites W1587411888 @default.
- W4291002775 cites W1809465031 @default.
- W4291002775 cites W1965258774 @default.
- W4291002775 cites W1967297513 @default.
- W4291002775 cites W1971635792 @default.
- W4291002775 cites W1974677375 @default.
- W4291002775 cites W1975933816 @default.
- W4291002775 cites W1981336564 @default.
- W4291002775 cites W1983079740 @default.
- W4291002775 cites W1985980866 @default.
- W4291002775 cites W2000518846 @default.
- W4291002775 cites W2001404020 @default.
- W4291002775 cites W2002474633 @default.
- W4291002775 cites W2018805974 @default.
- W4291002775 cites W2019062483 @default.
- W4291002775 cites W2034949980 @default.
- W4291002775 cites W2037643815 @default.
- W4291002775 cites W2041196497 @default.
- W4291002775 cites W2050753573 @default.
- W4291002775 cites W2063593731 @default.
- W4291002775 cites W2068754198 @default.
- W4291002775 cites W2071533207 @default.
- W4291002775 cites W2088717724 @default.
- W4291002775 cites W2090027454 @default.
- W4291002775 cites W2093953626 @default.
- W4291002775 cites W2101863298 @default.
- W4291002775 cites W2106096425 @default.
- W4291002775 cites W2107934021 @default.
- W4291002775 cites W2109436855 @default.
- W4291002775 cites W2117841787 @default.
- W4291002775 cites W2119008187 @default.
- W4291002775 cites W2119878439 @default.
- W4291002775 cites W2121076289 @default.
- W4291002775 cites W2121210640 @default.
- W4291002775 cites W2124028447 @default.
- W4291002775 cites W2133646735 @default.
- W4291002775 cites W2143977151 @default.
- W4291002775 cites W2146025254 @default.
- W4291002775 cites W2147893876 @default.
- W4291002775 cites W2158924104 @default.
- W4291002775 cites W2161051601 @default.
- W4291002775 cites W2170746912 @default.
- W4291002775 cites W2190199302 @default.
- W4291002775 cites W2268921967 @default.
- W4291002775 cites W2561857413 @default.
- W4291002775 cites W2603757358 @default.
- W4291002775 cites W2605532123 @default.
- W4291002775 cites W2729351500 @default.
- W4291002775 cites W2753429534 @default.
- W4291002775 cites W2757327684 @default.
- W4291002775 cites W2809245338 @default.
- W4291002775 cites W2884323144 @default.
- W4291002775 cites W2901786638 @default.
- W4291002775 cites W2909993605 @default.
- W4291002775 cites W2934339908 @default.
- W4291002775 cites W2942678593 @default.
- W4291002775 cites W2966214074 @default.
- W4291002775 cites W2974166216 @default.
- W4291002775 cites W2974808360 @default.
- W4291002775 cites W2993846314 @default.
- W4291002775 cites W2994788835 @default.
- W4291002775 cites W3001516551 @default.
- W4291002775 cites W3003215804 @default.
- W4291002775 cites W3011242662 @default.
- W4291002775 cites W3029507080 @default.
- W4291002775 cites W3033663536 @default.
- W4291002775 cites W3041196067 @default.
- W4291002775 cites W3042947402 @default.
- W4291002775 cites W3047840630 @default.
- W4291002775 cites W3080543750 @default.
- W4291002775 cites W3095097659 @default.
- W4291002775 cites W3095661013 @default.
- W4291002775 cites W3107357161 @default.
- W4291002775 cites W3111808177 @default.
- W4291002775 cites W3114686042 @default.
- W4291002775 cites W3116060911 @default.
- W4291002775 cites W3133077596 @default.
- W4291002775 cites W3158185358 @default.
- W4291002775 cites W3175807334 @default.
- W4291002775 cites W3199652116 @default.
- W4291002775 cites W3205965790 @default.
- W4291002775 cites W3207828649 @default.
- W4291002775 cites W3216449336 @default.
- W4291002775 cites W326932590 @default.
- W4291002775 cites W4206379059 @default.
- W4291002775 cites W4206987421 @default.
- W4291002775 cites W4211114435 @default.
- W4291002775 cites W4214944476 @default.
- W4291002775 cites W4220806983 @default.