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• W4291003798 abstract "Lymphatic filariasis (LF) is a mosquito-borne disease caused by filarial nematodes including Brugia malayi . Over 860 million people worldwide are infected or at risk of infection in 72 endemic countries. The absence of a protective vaccine means that current control strategies rely on mass drug administration programs that utilize inadequate drugs that cannot effectively kill adult parasites, thus established infections are incurable. Progress to address deficiencies in the approach to LF control is hindered by a poor mechanistic understanding of host-parasite interactions, including mechanisms of host immunomodulation by the parasite, a critical adaptation for establishing and maintaining infections. The canonical type 2 host response to helminth infection characterized by anti-inflammatory and regulatory immune phenotypes is modified by filarial nematodes during chronic LF. Current efforts at identifying parasite-derived factors driving this modification focus on parasite excretory-secretory products (ESP), including extracellular vesicles (EVs). We have previously profiled the cargo of B. malayi EVs and identified B. malayi galectin-1 and galectin-2 as among the most abundant EV proteins. In this study we further investigated the function of these proteins. Sequence analysis of the parasite galectins revealed highest homology to mammalian galectin-9 and functional characterization identified similar substrate affinities consistent with this designation. Immunological assays showed that Bma-LEC-2 is a bioactive protein that can polarize macrophages to an alternatively activated phenotype and selectively induce apoptosis in Th1 cells. Our data shows that an abundantly secreted parasite galectin is immunomodulatory and induces phenotypes consistent with the modified type 2 response characteristic of chronic LF infection." @default.
• W4291003798 created "2022-08-13" @default.
• W4291003798 creator A5011820270 @default.
• W4291003798 creator A5054872678 @default.
• W4291003798 creator A5075885048 @default.
• W4291003798 creator A5087361753 @default.
• W4291003798 date "2022-08-11" @default.
• W4291003798 modified "2023-09-26" @default.
• W4291003798 title "Secreted filarial nematode galectins modulate host immune cells" @default.
• W4291003798 cites W1603126127 @default.
• W4291003798 cites W1603469396 @default.
• W4291003798 cites W1638424324 @default.
• W4291003798 cites W1968169978 @default.
• W4291003798 cites W1968801556 @default.
• W4291003798 cites W1983824821 @default.
• W4291003798 cites W1985997449 @default.
• W4291003798 cites W1988128973 @default.
• W4291003798 cites W1995853066 @default.
• W4291003798 cites W1996032846 @default.
• W4291003798 cites W1997731331 @default.
• W4291003798 cites W2001203844 @default.
• W4291003798 cites W2002006009 @default.
• W4291003798 cites W2002516194 @default.
• W4291003798 cites W2003084688 @default.
• W4291003798 cites W2008382341 @default.
• W4291003798 cites W2009432847 @default.
• W4291003798 cites W2012625663 @default.
• W4291003798 cites W2013177587 @default.
• W4291003798 cites W2014029442 @default.
• W4291003798 cites W2016081852 @default.
• W4291003798 cites W2021682946 @default.
• W4291003798 cites W2022828031 @default.
• W4291003798 cites W2024722792 @default.
• W4291003798 cites W2027872459 @default.
• W4291003798 cites W2028117344 @default.
• W4291003798 cites W2030755802 @default.
• W4291003798 cites W2031627869 @default.
• W4291003798 cites W2053289663 @default.
• W4291003798 cites W2055313665 @default.
• W4291003798 cites W2055453678 @default.
• W4291003798 cites W2067332058 @default.
• W4291003798 cites W2068128836 @default.
• W4291003798 cites W2069126031 @default.
• W4291003798 cites W2070631889 @default.
• W4291003798 cites W2085628862 @default.
• W4291003798 cites W2089324082 @default.
• W4291003798 cites W2098380988 @default.
• W4291003798 cites W2103889606 @default.
• W4291003798 cites W2109160513 @default.
• W4291003798 cites W2113071839 @default.
• W4291003798 cites W2113649995 @default.
• W4291003798 cites W2116196443 @default.
• W4291003798 cites W2122591224 @default.
• W4291003798 cites W2125198788 @default.
• W4291003798 cites W2127604250 @default.
• W4291003798 cites W2131492616 @default.
• W4291003798 cites W2132054009 @default.
• W4291003798 cites W2133831816 @default.
• W4291003798 cites W2142015379 @default.
• W4291003798 cites W2143206909 @default.
• W4291003798 cites W2146634463 @default.
• W4291003798 cites W2149545956 @default.
• W4291003798 cites W2151508278 @default.
• W4291003798 cites W2151715379 @default.
• W4291003798 cites W2152044035 @default.
• W4291003798 cites W2152349340 @default.
• W4291003798 cites W2154159239 @default.
• W4291003798 cites W2155271571 @default.
• W4291003798 cites W2169983473 @default.
• W4291003798 cites W2179282661 @default.
• W4291003798 cites W2340102652 @default.
• W4291003798 cites W2443062563 @default.
• W4291003798 cites W2505849117 @default.
• W4291003798 cites W2554014031 @default.
• W4291003798 cites W2559577985 @default.
• W4291003798 cites W2588229349 @default.
• W4291003798 cites W2606317321 @default.
• W4291003798 cites W2618954565 @default.
• W4291003798 cites W2763198484 @default.
• W4291003798 cites W2786514708 @default.
• W4291003798 cites W2799531105 @default.
• W4291003798 cites W2800511498 @default.
• W4291003798 cites W2802510600 @default.
• W4291003798 cites W2802981078 @default.
• W4291003798 cites W2914340301 @default.
• W4291003798 cites W2938574745 @default.
• W4291003798 cites W2950320278 @default.
• W4291003798 cites W2965473572 @default.
• W4291003798 cites W2985205513 @default.
• W4291003798 cites W2985550663 @default.
• W4291003798 cites W3012389880 @default.
• W4291003798 cites W3034999515 @default.
• W4291003798 cites W3040770894 @default.
• W4291003798 cites W3081444048 @default.
• W4291003798 cites W3111432318 @default.
• W4291003798 cites W3119653480 @default.
• W4291003798 cites W3158816625 @default.
• W4291003798 cites W4235675956 @default.
• W4291003798 doi "https://doi.org/10.3389/fimmu.2022.952104" @default.
• W4291003798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36032131" @default.

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