Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291010285> ?p ?o ?g. }
- W4291010285 abstract "Abstract Background Borderline Personality Disorder (BPD) symptoms often emerge in adolescence. However, little is known about the functional organization of intrinsic brain networks in young people with BPD symptoms. Methods In this study we collected resting-state fMRI data in a sample of adolescents and young adults with (n BPD = 40) and without BPD (n HC = 42) symptoms. Using a detailed cortico-limbic parcellation coupled with graph theoretical analyses, we tested for group and age-related differences in regional functional and effective connectivity (FC, EC) and amplitude of low frequency fluctuations (ALFF). We conducted a series of analyses that progressed from global network properties to focal tests of EC amongst nodes in Salience (SN) and Dorsal Attention Networks (DAN). Results At the regional level, regularized regression analyses revealed a broad pattern of hyper-connectivity and heightened ALFF in R dorsal anterior insula (daIns), in addition to hypoconnectivity in R temporal-parietal junction (TPJ) and decreased ALFF in multiple DAN regions. Furthermore, analyses of EC amongst daIns, TPJ, and DAN revealed that in BPD participants daIns exerts a heightened influence on TPJ and DAN regions. Finally, multivariate mediation models indicated that lower DAN ALFF was differentially predicted by EC from TPJ and daIns. Conclusions Our findings provide converging evidence that heightened EC from daIns impairs network-wide ALFF in DAN both directly and indirectly via impaired TPJ functioning. We interpret this pattern of findings in line with an “attentional hijacking” account of borderline personality." @default.
- W4291010285 created "2022-08-13" @default.
- W4291010285 creator A5049648099 @default.
- W4291010285 creator A5081751872 @default.
- W4291010285 date "2022-08-11" @default.
- W4291010285 modified "2023-09-27" @default.
- W4291010285 title "Right anterior insula effective connectivity impairs intrinsic BOLD fluctuations in dorsal attention network in adolescents and young adults with borderline personality symptoms" @default.
- W4291010285 cites W1708732123 @default.
- W4291010285 cites W1968439746 @default.
- W4291010285 cites W1970597681 @default.
- W4291010285 cites W1973816549 @default.
- W4291010285 cites W1992600467 @default.
- W4291010285 cites W1995180357 @default.
- W4291010285 cites W1995935670 @default.
- W4291010285 cites W2003220763 @default.
- W4291010285 cites W2005933475 @default.
- W4291010285 cites W2007380852 @default.
- W4291010285 cites W2009494091 @default.
- W4291010285 cites W2016521818 @default.
- W4291010285 cites W2018305040 @default.
- W4291010285 cites W2019370496 @default.
- W4291010285 cites W2020044743 @default.
- W4291010285 cites W2025009638 @default.
- W4291010285 cites W2028964134 @default.
- W4291010285 cites W2032602740 @default.
- W4291010285 cites W2042496130 @default.
- W4291010285 cites W2047453615 @default.
- W4291010285 cites W2055345898 @default.
- W4291010285 cites W2061564920 @default.
- W4291010285 cites W2063018860 @default.
- W4291010285 cites W2072799373 @default.
- W4291010285 cites W2084260707 @default.
- W4291010285 cites W2085423000 @default.
- W4291010285 cites W2091659485 @default.
- W4291010285 cites W2093967694 @default.
- W4291010285 cites W2096890573 @default.
- W4291010285 cites W2100831964 @default.
- W4291010285 cites W2102139723 @default.
- W4291010285 cites W2105409252 @default.
- W4291010285 cites W2108270119 @default.
- W4291010285 cites W2116136260 @default.
- W4291010285 cites W2116658855 @default.
- W4291010285 cites W2119121152 @default.
- W4291010285 cites W2119195417 @default.
- W4291010285 cites W2119291948 @default.
- W4291010285 cites W2120120116 @default.
- W4291010285 cites W2129624700 @default.
- W4291010285 cites W2133144527 @default.
- W4291010285 cites W2136835047 @default.
- W4291010285 cites W2139816784 @default.
- W4291010285 cites W2144325046 @default.
- W4291010285 cites W2145729305 @default.
- W4291010285 cites W2146278257 @default.
- W4291010285 cites W2148050838 @default.
- W4291010285 cites W2156014011 @default.
- W4291010285 cites W2157997973 @default.
- W4291010285 cites W2161502085 @default.
- W4291010285 cites W2162208119 @default.
- W4291010285 cites W2163031178 @default.
- W4291010285 cites W2163559749 @default.
- W4291010285 cites W2164971948 @default.
- W4291010285 cites W2167822639 @default.
- W4291010285 cites W2170419722 @default.
- W4291010285 cites W2210063156 @default.
- W4291010285 cites W2218776046 @default.
- W4291010285 cites W2468117220 @default.
- W4291010285 cites W2568027254 @default.
- W4291010285 cites W2568728987 @default.
- W4291010285 cites W2609106615 @default.
- W4291010285 cites W2613539104 @default.
- W4291010285 cites W2732740969 @default.
- W4291010285 cites W2735296369 @default.
- W4291010285 cites W2763918205 @default.
- W4291010285 cites W2793036539 @default.
- W4291010285 cites W2811108821 @default.
- W4291010285 cites W2863032097 @default.
- W4291010285 cites W2883544214 @default.
- W4291010285 cites W2894949518 @default.
- W4291010285 cites W2905853383 @default.
- W4291010285 cites W2911857851 @default.
- W4291010285 cites W2920690149 @default.
- W4291010285 cites W2925608866 @default.
- W4291010285 cites W2949073807 @default.
- W4291010285 cites W2951617899 @default.
- W4291010285 cites W2952857756 @default.
- W4291010285 cites W2953406849 @default.
- W4291010285 cites W2955887129 @default.
- W4291010285 cites W2984087519 @default.
- W4291010285 cites W2985441701 @default.
- W4291010285 cites W2988057732 @default.
- W4291010285 cites W3028447440 @default.
- W4291010285 cites W3120713197 @default.
- W4291010285 cites W3161535964 @default.
- W4291010285 cites W4211091012 @default.
- W4291010285 cites W4214593718 @default.
- W4291010285 cites W4238599281 @default.
- W4291010285 cites W4254909614 @default.
- W4291010285 cites W4295750005 @default.
- W4291010285 doi "https://doi.org/10.1101/2022.08.08.503183" @default.
- W4291010285 hasPublicationYear "2022" @default.