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• W4291015596 abstract "Many studies have shown that abdominal adiposity is more strongly related to health risks than peripheral adiposity. However, the underlying pathways are still poorly understood. In this cross-sectional study using data from RNA-sequencing experiments and whole-body MRI scans of 200 participants in the EPIC-Potsdam cohort, our aim was to identify novel genes whose gene expression in subcutaneous adipose tissue has an effect on body fat mass (BFM) and body fat distribution (BFD). The analysis identified 625 genes associated with adiposity, of which 531 encode a known protein and 487 are novel candidate genes for obesity. Enrichment analyses indicated that BFM-associated genes were characterized by their higher than expected involvement in cellular, regulatory and immune system processes, and BFD-associated genes by their involvement in cellular, metabolic, and regulatory processes. Mendelian Randomization analyses suggested that the gene expression of 69 genes was causally related to BFM and BFD. Six genes were replicated in UK Biobank. In this study, we identified novel genes for BFM and BFD that are BFM- and BFD-specific, involved in different molecular processes, and whose up-/downregulated gene expression may causally contribute to obesity." @default.
• W4291015596 created "2022-08-13" @default.
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• W4291015596 date "2022-08-11" @default.
• W4291015596 modified "2023-10-18" @default.
• W4291015596 title "Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study" @default.
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• W4291015596 doi "https://doi.org/10.1038/s41431-022-01161-3" @default.
• W4291015596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35953519" @default.
• W4291015596 hasPublicationYear "2022" @default.
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