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- W4291016475 abstract "Autophagy is a self-degradation process in which damaged proteins and organelles are engulfed into autophagosomes for digestion and eventually recycled for cellular metabolism to maintain intracellular homeostasis. Accumulating studies have reported that autophagy has the Janus role in cancer as a tumor suppressor or an oncogenic role to promote the growth of established tumors and developing drug resistance. Importantly, cytoprotective autophagy plays a prominent role in many types of human cancers, thus inhibiting autophagy, and has been regarded as a promising therapeutic strategy for cancer therapy. Here, we focus on summarizing small-molecule compounds inhibiting the autophagy process, as well as further discuss other dual-target small-molecule compounds, combination strategies, and other strategies to improve potential cancer therapy. Therefore, these findings will shed new light on exploiting more small-molecule compounds inhibiting cytoprotective autophagy as candidate drugs for fighting human cancers in the future." @default.
- W4291016475 created "2022-08-13" @default.
- W4291016475 creator A5003547177 @default.
- W4291016475 creator A5014959458 @default.
- W4291016475 creator A5041015608 @default.
- W4291016475 creator A5071074966 @default.
- W4291016475 creator A5078526337 @default.
- W4291016475 date "2022-08-11" @default.
- W4291016475 modified "2023-10-14" @default.
- W4291016475 title "Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds" @default.
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