FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291017572> ?p ?o ?g. }

• W4291017572 abstract "Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on glutamatergic levels in the anterior cingulate cortex (ACC), and whether there is a relationship between baseline glutamatergic levels and clinical response after antipsychotic treatment in people with first episode psychosis (FEP).The sample comprised 25 FEP patients; 22 completed magnetic resonance spectroscopy scans at both timepoints. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).There was no significant change in glutamate [baseline 13.23 ± 2.33; follow-up 13.89 ± 1.74; t(21) = -1.158, p = 0.260], or Glx levels [baseline 19.64 ± 3.26; follow-up 19.66 ± 2.65; t(21) = -0.034, p = 0.973]. There was no significant association between glutamate or Glx levels at baseline and the change in PANSS positive (Glu r = 0.061, p = 0.777, Glx r = -0.152, p = 0.477), negative (Glu r = 0.144, p = 0.502, Glx r = 0.052, p = 0.811), general (Glu r = 0.110, p = 0.607, Glx r = -0.212, p = 0.320), or total scores (Glu r = 0.078, p = 0.719 Glx r = -0.155, p = 0.470).These findings indicate that treatment response is unlikely to be associated with baseline glutamatergic metabolites prior to antipsychotic treatment, and there is no major effect of antipsychotic treatment on glutamatergic metabolites in the ACC." @default.
• W4291017572 created "2022-08-13" @default.
• W4291017572 creator A5001601365 @default.
• W4291017572 creator A5021535537 @default.
• W4291017572 creator A5022138939 @default.
• W4291017572 creator A5025544949 @default.
• W4291017572 creator A5030153931 @default.
• W4291017572 creator A5033398453 @default.
• W4291017572 creator A5039005518 @default.
• W4291017572 creator A5048818641 @default.
• W4291017572 creator A5073964938 @default.
• W4291017572 creator A5079066852 @default.
• W4291017572 creator A5081507748 @default.
• W4291017572 creator A5084783332 @default.
• W4291017572 date "2022-08-11" @default.
• W4291017572 modified "2023-09-30" @default.
• W4291017572 title "The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients" @default.
• W4291017572 cites W114047989 @default.
• W4291017572 cites W1518890501 @default.
• W4291017572 cites W1638218062 @default.
• W4291017572 cites W1963540461 @default.
• W4291017572 cites W1970448316 @default.
• W4291017572 cites W1971964143 @default.
• W4291017572 cites W1984250632 @default.
• W4291017572 cites W1995221679 @default.
• W4291017572 cites W1995582028 @default.
• W4291017572 cites W2000636120 @default.
• W4291017572 cites W2008639041 @default.
• W4291017572 cites W2009801894 @default.
• W4291017572 cites W2013514700 @default.
• W4291017572 cites W2014296883 @default.
• W4291017572 cites W2024707649 @default.
• W4291017572 cites W2027300442 @default.
• W4291017572 cites W2047120106 @default.
• W4291017572 cites W2057429979 @default.
• W4291017572 cites W2060529079 @default.
• W4291017572 cites W2064334410 @default.
• W4291017572 cites W2078881206 @default.
• W4291017572 cites W2082642969 @default.
• W4291017572 cites W2084053184 @default.
• W4291017572 cites W2093248761 @default.
• W4291017572 cites W2099185967 @default.
• W4291017572 cites W2113207016 @default.
• W4291017572 cites W2118096594 @default.
• W4291017572 cites W2125653585 @default.
• W4291017572 cites W2140606211 @default.
• W4291017572 cites W2159039084 @default.
• W4291017572 cites W2160952465 @default.
• W4291017572 cites W2161503386 @default.
• W4291017572 cites W2217483770 @default.
• W4291017572 cites W2335523060 @default.
• W4291017572 cites W2560754155 @default.
• W4291017572 cites W2605229048 @default.
• W4291017572 cites W2609221543 @default.
• W4291017572 cites W2762826535 @default.
• W4291017572 cites W2780349532 @default.
• W4291017572 cites W2801427800 @default.
• W4291017572 cites W2807268163 @default.
• W4291017572 cites W2889742508 @default.
• W4291017572 cites W2911023731 @default.
• W4291017572 cites W2953798536 @default.
• W4291017572 cites W2958423778 @default.
• W4291017572 cites W2982685163 @default.
• W4291017572 cites W2995641799 @default.
• W4291017572 cites W2999889141 @default.
• W4291017572 cites W2999966539 @default.
• W4291017572 cites W3022229671 @default.
• W4291017572 cites W3022484871 @default.
• W4291017572 cites W3026344230 @default.
• W4291017572 cites W3033732590 @default.
• W4291017572 cites W3086533835 @default.
• W4291017572 cites W3155984011 @default.
• W4291017572 doi "https://doi.org/10.3389/fpsyt.2022.967941" @default.
• W4291017572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36032237" @default.
• W4291017572 hasPublicationYear "2022" @default.
• W4291017572 type Work @default.
• W4291017572 citedByCount "0" @default.
• W4291017572 crossrefType "journal-article" @default.
• W4291017572 hasAuthorship W4291017572A5001601365 @default.
• W4291017572 hasAuthorship W4291017572A5021535537 @default.
• W4291017572 hasAuthorship W4291017572A5022138939 @default.
• W4291017572 hasAuthorship W4291017572A5025544949 @default.
• W4291017572 hasAuthorship W4291017572A5030153931 @default.
• W4291017572 hasAuthorship W4291017572A5033398453 @default.
• W4291017572 hasAuthorship W4291017572A5039005518 @default.
• W4291017572 hasAuthorship W4291017572A5048818641 @default.
• W4291017572 hasAuthorship W4291017572A5073964938 @default.
• W4291017572 hasAuthorship W4291017572A5079066852 @default.
• W4291017572 hasAuthorship W4291017572A5081507748 @default.
• W4291017572 hasAuthorship W4291017572A5084783332 @default.
• W4291017572 hasBestOaLocation W42910175721 @default.
• W4291017572 hasConcept C118552586 @default.
• W4291017572 hasConcept C126322002 @default.
• W4291017572 hasConcept C134018914 @default.
• W4291017572 hasConcept C15744967 @default.
• W4291017572 hasConcept C169900460 @default.
• W4291017572 hasConcept C170493617 @default.
• W4291017572 hasConcept C2776412080 @default.
• W4291017572 hasConcept C2778402161 @default.
• W4291017572 hasConcept C2779727114 @default.

• next