Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291017730> ?p ?o ?g. }
- W4291017730 abstract "Retroperitoneal liposarcomas (RPLPSs) are a rare tumor group for which current guidelines recommend aggressive en bloc resection to attain microscopically negative (R0) margins. To ensure R0 margins, resection of adherent or adjacent organs is often required. However, it is still unclear if R0 margins confer any additional benefit to patients over a grossly negative but microscopically positive (R1) margin. We performed a systematic search of PubMed and Embase databases for studies including patients receiving R0 or R1 resection for RPLPS. Nine retrospective cohort studies, one prospective cohort study, and 49 case reports/case series were included. A total of 552 patients with RPLPS were evaluated: 346 underwent R0 resection and 206 underwent R1 resection. In the R0 group, 5-year overall survival (OS) ranged from 58.3% to 85.7%; local recurrence (LR) ranged from 45.5% to 52.3%. In the R1 group, 5-year OS ranged from 35% to 55.3%; LR ranged from 66.7% to 91.7%. Among cohort studies, OS, disease-free survival (DFS), LR rate, and LR-free survival (LRFS) were significantly associated with R0 resections. Assessment of case series and reports suggested that the R0 margin led to a slightly higher morbidity than that of R1. In conclusion, this review found the R0 margin to be associated with reductions in LR rates and improved OS when compared with the R1 margins, though accompanied by slight increases in morbidity. The roles of tumor histotype and perioperative chemotherapy or radiotherapy were not well-elucidated in this review." @default.
- W4291017730 created "2022-08-13" @default.
- W4291017730 creator A5034719816 @default.
- W4291017730 creator A5038414658 @default.
- W4291017730 creator A5051687974 @default.
- W4291017730 creator A5053082742 @default.
- W4291017730 creator A5056641781 @default.
- W4291017730 creator A5058476462 @default.
- W4291017730 creator A5067176456 @default.
- W4291017730 creator A5082193096 @default.
- W4291017730 date "2022-08-11" @default.
- W4291017730 modified "2023-09-30" @default.
- W4291017730 title "A systematic review of margin status in retroperitoneal liposarcomas: Does the R0 margin matter?" @default.
- W4291017730 cites W1412157 @default.
- W4291017730 cites W1485953657 @default.
- W4291017730 cites W1492460581 @default.
- W4291017730 cites W1780514346 @default.
- W4291017730 cites W1849702850 @default.
- W4291017730 cites W1943787146 @default.
- W4291017730 cites W1971278892 @default.
- W4291017730 cites W1972278535 @default.
- W4291017730 cites W1974743131 @default.
- W4291017730 cites W1991038269 @default.
- W4291017730 cites W1998805988 @default.
- W4291017730 cites W2001407013 @default.
- W4291017730 cites W2005127412 @default.
- W4291017730 cites W2007693558 @default.
- W4291017730 cites W2009135068 @default.
- W4291017730 cites W2009262824 @default.
- W4291017730 cites W2013994531 @default.
- W4291017730 cites W2016969094 @default.
- W4291017730 cites W2040081472 @default.
- W4291017730 cites W2045722245 @default.
- W4291017730 cites W2058765637 @default.
- W4291017730 cites W2069111865 @default.
- W4291017730 cites W2073751452 @default.
- W4291017730 cites W2088303301 @default.
- W4291017730 cites W2092601460 @default.
- W4291017730 cites W2098225751 @default.
- W4291017730 cites W2108250629 @default.
- W4291017730 cites W2108766853 @default.
- W4291017730 cites W2117351664 @default.
- W4291017730 cites W2129256377 @default.
- W4291017730 cites W2134833483 @default.
- W4291017730 cites W2137048141 @default.
- W4291017730 cites W2144173184 @default.
- W4291017730 cites W2146545977 @default.
- W4291017730 cites W2146836406 @default.
- W4291017730 cites W2148327333 @default.
- W4291017730 cites W2148802044 @default.
- W4291017730 cites W2149658240 @default.
- W4291017730 cites W2150233507 @default.
- W4291017730 cites W2154012133 @default.
- W4291017730 cites W2164192021 @default.
- W4291017730 cites W2167982657 @default.
- W4291017730 cites W2171449535 @default.
- W4291017730 cites W2199095907 @default.
- W4291017730 cites W2318872159 @default.
- W4291017730 cites W2320378741 @default.
- W4291017730 cites W2323526189 @default.
- W4291017730 cites W2400620570 @default.
- W4291017730 cites W2408832173 @default.
- W4291017730 cites W2411991920 @default.
- W4291017730 cites W2422785769 @default.
- W4291017730 cites W2460944621 @default.
- W4291017730 cites W2464293938 @default.
- W4291017730 cites W2497983649 @default.
- W4291017730 cites W2520989374 @default.
- W4291017730 cites W2521061404 @default.
- W4291017730 cites W2604557527 @default.
- W4291017730 cites W2620915302 @default.
- W4291017730 cites W2741304159 @default.
- W4291017730 cites W2766619138 @default.
- W4291017730 cites W2766924782 @default.
- W4291017730 cites W2768225915 @default.
- W4291017730 cites W2769103467 @default.
- W4291017730 cites W2769163279 @default.
- W4291017730 cites W2771758372 @default.
- W4291017730 cites W2783631626 @default.
- W4291017730 cites W2803461932 @default.
- W4291017730 cites W2883645212 @default.
- W4291017730 cites W2883818737 @default.
- W4291017730 cites W2883938353 @default.
- W4291017730 cites W2888323813 @default.
- W4291017730 cites W2896613874 @default.
- W4291017730 cites W2915207028 @default.
- W4291017730 cites W2924659475 @default.
- W4291017730 cites W2944142616 @default.
- W4291017730 cites W2948064335 @default.
- W4291017730 cites W2951489660 @default.
- W4291017730 cites W2964312447 @default.
- W4291017730 cites W2974300479 @default.
- W4291017730 cites W2979796523 @default.
- W4291017730 cites W3086258129 @default.
- W4291017730 cites W3092777424 @default.
- W4291017730 cites W312411441 @default.
- W4291017730 cites W3154422727 @default.
- W4291017730 cites W4244970282 @default.
- W4291017730 cites W4248017777 @default.
- W4291017730 doi "https://doi.org/10.3389/fonc.2022.891710" @default.