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- W4291019928 endingPage "109093" @default.
- W4291019928 startingPage "109093" @default.
- W4291019928 abstract "Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emerging evidence indicates that the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated, which results in a cytokine storm at the late stage of COVID-19. Autophagy regulation is involved in the infection and replication of SARS-CoV-2 at the early stage and the inhibition of NLRP3 inflammasome-mediated lung inflammation at the late stage of COVID-19. Here, we discuss the autophagy regulation at different stages of COVID-19. Specifically, we highlight the therapeutic potential of autophagy activators in COVID-19 by inhibiting the NLRP3 inflammasome, thereby avoiding the cytokine storm. We hope this review provides enlightenment for the use of autophagy activators targeting the inhibition of the NLRP3 inflammasome, specifically the combinational therapy of autophagy modulators with the inhibitors of the NLRP3 inflammasome, antiviral drugs, or anti-inflammatory drugs in the fight against COVID-19." @default.
- W4291019928 created "2022-08-13" @default.
- W4291019928 creator A5004346404 @default.
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- W4291019928 creator A5090187166 @default.
- W4291019928 date "2022-11-01" @default.
- W4291019928 modified "2023-10-14" @default.
- W4291019928 title "Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19" @default.
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